Superoxide Dismutase 2, Mitochondrial Proteine (SOD2)

Bezeichnung:
Superoxide Dismutase 2, Mitochondrial Proteine (SOD2)
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Synonyme:
cb463, CG8905, Dmel\\CG8905, dSOD2, GB14346, IPOB, LOC100101896, MGC88869, Mito SOD, mitSOD2, Mn-SOD, Mn-SOD2, mnSOD, Mn SOD, MnSODII, Mn[2+]SOD, MVCD6, SOD, Sod-2, SOD2, wu:fj33b01, zgc:73051
alle Proteine anzeigen Gen GeneID UniProt
SOD2 6648 P04179
SOD2 20656 P09671
SOD2 24787 P07895

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Am meisten referenzierte Superoxide Dismutase 2, Mitochondrial Proteine

  1. Rat (Rattus) SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN1686709 : Adachi, Ohta, Yamada, Futenma, Kato, Hirano: Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody. in Clinica chimica acta; international journal of clinical chemistry 1993 (PubMed)
    Zeige alle 2 Referenzen für 1686709

  2. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN666966 : MacMillan-Crow, Thompson: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. in Archives of biochemistry and biophysics 1999 (PubMed)
    Zeige alle 2 Referenzen für 666966

  3. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN1686712 : Wispé, Clark, Burhans, Kropp, Korfhagen, Whitsett: Synthesis and processing of the precursor for human mangano-superoxide dismutase. in Biochimica et biophysica acta 1989 (PubMed)
    Zeige alle 2 Referenzen für 1686712

  4. Human SOD2 Protein expressed in Wheat germ - ABIN1320944 : Yang, Xiao, Zhang, Li, Zhang, Li, Chen, Zhu, Sun, Liu, Chen: Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. in Journal of proteome research 2007 (PubMed)

Weitere Proteine zu Superoxide Dismutase 2, Mitochondrial Interaktionspartnern

Rabbit Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. Prion (zeige PRNP Proteine) propagation exacerbates an apoptotic pathway whereby mitochondrial dysfunction follows mislocalisation of SOD2 to cytosolic caspases permitting its degradation.

Fruit Fly (Drosophila melanogaster) Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. Depletion of superoxide dismutases promotes muscular and neuronal ROS (zeige ROS1 Proteine) accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.

  2. Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.

  3. The functional SOD1 (zeige SOD1 Proteine) and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.

  4. ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS (zeige ROS1 Proteine) is not essential for oocyte viability

  5. Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.

  6. Overexpression of Cu,ZnSOD (zeige SOD1 Proteine) and MnSOD in transgenic Drosophila.

  7. Ablation of mitochondrial SOD2 through expression of a GAL4 (zeige LGALS4 Proteine)-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults.

  8. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.

  9. The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression.

  10. SOD1 (zeige SOD1 Proteine) and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress

Human Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. Low MnSOD expression is associated with Prostate Cancer.

  2. High MNSOD expression is associated with Thyroid Tumors.

  3. Findings suggest that the Ala16Val-MnSOD SNPs may contribute to hypercholesterolemia and higher GLU (zeige DCTN1 Proteine) levels, increasing the risk to neurovascular events that may lead to stroke.

  4. Results suggest some pharmacogenetic effects of Val16Ala-SOD2 in hypercholesterolemia patients undergoing rosuvastatin treatment.

  5. he data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3 (zeige SIRT3 Proteine)-SOD2-ROS (zeige ROS1 Proteine) signaling

  6. WT-MnSOD protein conserves a destabilizing amino acid at position 146 as part of a strategy to favor metal ion binding.

  7. There is significant association between SOD (zeige SOD1 Proteine) rs4880 polymorphism and pulmonary arterial hypertension (PAH) susceptibility, and this polymorphism influenced PAH susceptibility by altering the expression of SOD2.

  8. It is suggested that the MnSOD A16V polymorphism may be associated with a risk of female infertility in northern Iran.

  9. Mutated obese carries of SOD1 (zeige SOD1 Proteine) -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers.

  10. Changes of Sig1R (zeige SIGMAR1 Proteine) and SOD2 expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.

Pig (Porcine) Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. show that ischemia markedly potentiated the expression of arginase-1 (zeige ARG1 Proteine), and also induced the SOD2 in the wound tissue.

Cow (Bovine) Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2, GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.

  2. Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.

  3. expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)

  4. Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.

  5. The expression of SOD1 (zeige SOD1 Proteine) and SOD2 through the course of the estrous cycle is reported.

  6. Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not

Mouse (Murine) Superoxide Dismutase 2, Mitochondrial (SOD2) Interaktionspartner

  1. We investigated the role of Mn-SOD in NIHL by examining the extent of hearing loss and hair cell damage after noise exposure in C57BL/6 wild-type (WT) mice and Mn-SOD heterozygous knockout (HET) mice. Mean ABR thresholds were significantly worse on post-noise exposure days 7 and 14 in HET mice compared with WT mice. Outer hair cell damage was significantly greater in all cochlear turns in HET mice compared with WT mice.

  2. Data suggest that negative regulatory effect of Sirt3 (zeige SIRT3 Proteine) on Nlrp3 (zeige NLRP3 Proteine) inflammasome assembly in macrophages due to prolonged fasting occurs via Sirt3 (zeige SIRT3 Proteine)-mediated deacetylation of mitochondrial Sod2, leading to Sod2 activation; prolonged fasting blunts inflammasomes in wild-type mice but not in Sirt3 (zeige SIRT3 Proteine) knock-out mice. (Sirt3 (zeige SIRT3 Proteine) = sirtuin 3 (zeige SIRT3 Proteine); Nlrp3 (zeige NLRP3 Proteine) = NLR (zeige CXCR5 Proteine) family, pyrin domain containing 3 protein; Sod2 = superoxide dismutase 2)

  3. Data show that overexpression of manganese superoxide dismutase (MnSOD) increased the expression of aquaporin-1 (AQP1 (zeige AQP1 Proteine))

  4. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (zeige SIRT3 Proteine) enrichment within the mitochondria and subsequent upregulation of FoxO3a (zeige FOXO3 Proteine)-mediated mitochondria gene expression of PGC-1alpha and SOD2.

  5. Thus, a ROS (zeige ROS1 Proteine)-dependent epigenetic positive regulation of Sod2 gene expression likely represents a defense mechanism prolonging eNOS (zeige NOS3 Proteine) function in aging mouse femoral arteries.

  6. In this review, we will conglomerate the current aspects by which MnSOD can contribute to embryonic stem cells' and adult stem cells' functions and interpret the necessity of understanding MnSOD for further stem cell mediated applications

  7. The results indicated that the inconsistency between Mn SOD expression and its activity might contribute to the development of recognition dysfunction induced by chronic Al overload.

  8. Evidence for a tumor suppressive role of MnSOD in liver, where the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and hypoxia pathway may be crucial elements.

  9. SOD2 overexpression in cardiomyocytes enhances mitochondrial function and metabolic vasodilation, leading to a phenotype of supernormal cardiac function.

  10. Pluripotency transcription factors Nanog (zeige NANOG Proteine) and Oct4 (zeige POU5F1 Proteine) positively modulate Sod2 gene transcription in induced pluripotent stem cells.

Superoxide Dismutase 2, Mitochondrial (SOD2) Protein Überblick

Protein Überblick

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Superoxide Dismutase 2, Mitochondrial (SOD2)

  • MnSOD (BDBG_07234)
  • MnSOD (LOC100101896)
  • manganese superoxide dismutase (GSVIVT00029451001)
  • superoxide dismutase 2, mitochondrial (Sod2)
  • superoxide dismutase 2, mitochondrial (sod2)
  • Mn superoxide dismutase (Sod2)
  • Mn superoxide dismutase (LbMnSOD4)
  • superoxide dismutase 2, mitochondrial (SOD2)
  • superoxide dismutase 2 (LOC100282741)
  • manganese superoxide dismutase (SOD-2)
  • Superoxide dismutase 2 (Mn) (Sod2)
  • cb463 Protein
  • CG8905 Protein
  • Dmel\\CG8905 Protein
  • dSOD2 Protein
  • GB14346 Protein
  • IPOB Protein
  • LOC100101896 Protein
  • MGC88869 Protein
  • Mito SOD Protein
  • mitSOD2 Protein
  • Mn-SOD Protein
  • Mn-SOD2 Protein
  • mnSOD Protein
  • Mn SOD Protein
  • MnSODII Protein
  • Mn[2+]SOD Protein
  • MVCD6 Protein
  • SOD Protein
  • Sod-2 Protein
  • SOD2 Protein
  • wu:fj33b01 Protein
  • zgc:73051 Protein

Bezeichner auf Proteinebene für SOD2

MnSOD , manganese superoxide dismutase , Mn Sod , Mn superoxide dismutase , superoxide dismutase 2, mitochondrial , superoxide dismutase [Mn], mitochondrial , GRMZM5G891739 , CG8905-PA , Mn-superoxide dismutase , Sod2-PA , manganese-SOD , mitochodnrial SOD , mitochondrial Mn-superoxide dismutase 2 , mitochondrial MnSOD , mitochondrial superoxide dismutase 2 , superoxide dismutase , superoxide dismutase 2 , superoxide dismutase 2 (Mn) , superoxide dismutase-2 , indophenoloxidase B , manganese-containing superoxide dismutase , mangano-superoxide dismutase , superoxide dismutase (Mn type) , manganous superoxide dismutase , manganese SOD , Superoxide dimutase 2, mitochondrial , Mn-SOD , sod(Mn)

GENE ID SPEZIES
8502558 Ajellomyces dermatitidis SLH14081
100101896 Glycine max
100233137 Vitis vinifera
410082 Apis mellifera
448200 Xenopus (Silurana) tropicalis
692736 Bombyx mori
6074587 Laccaria bicolor S238N-H82
100174061 Pongo abelii
100282741 Zea mays
100009336 Oryctolagus cuniculus
36878 Drosophila melanogaster
6648 Homo sapiens
399216 Xenopus laevis
374042 Gallus gallus
476258 Canis lupus familiaris
100154319 Sus scrofa
281496 Bos taurus
780457 Ovis aries
20656 Mus musculus
24787 Rattus norvegicus
100135623 Cavia porcellus
335799 Danio rerio
574097 Macaca mulatta
449634 Pan troglodytes
100410185 Callithrix jacchus
100034223 Equus caballus
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