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Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1 (zeige FGFR1 Proteine).
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (zeige CDC42 Proteine) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (zeige MAPK1 Proteine) cascades participate in osteogenesis, but only the ERK (zeige EPHB2 Proteine) signaling pathway responds to FGFR1 (zeige FGFR1 Proteine).
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (zeige FGFR2 Proteine) 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 Proteine) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Proteine) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (zeige FGFR1 Proteine), FGFR2 (zeige FGFR2 Proteine), and FGFR3 (zeige FGFR3 Proteine).
increased activity of the PI3K/AKT (zeige AKT1 Proteine) signaling pathway in Pelo (zeige PELO Proteine)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
clearly demonstrate the different specificity of FGF12 (zeige FGF12 Proteine)-FGFR1c2 and FGF22 (zeige FGF22 Proteine)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (zeige KLB Proteine) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (zeige FGFR2 Proteine)-betaKlotho (zeige KLB Proteine) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
In this study of 97 174 individuals from the Danish general population, FLG (zeige FGFR1 Proteine) loss-of-function mutations were associated with increased ischemic stroke risk
study found that among patients with atopic dermatitis (AD), common FLG (zeige FGFR1 Proteine) null mutations are associated with earlier AD onset in a dose-dependent manner, whereas TSLP (zeige TSLP Proteine) rs1898671 appears unrelated to the timing of AD onset
The two SNPs K4671X and rs3126085 of FLG (zeige FGFR1 Proteine) were related to Epstein-Barr virus (EBV)-associated gastric carcinoma.
FLG mutation is associated with IgE sensitization to peanut but not to other allergens in Swedish children up to 16 years of age
Erythemal doses of ultraviolet B exert acute effects on profilaggrin mRNA and filaggrin protein in human skin in vivo.
FLG (zeige FGFR1 Proteine) mutations are associated with early onset of atopic dermatitis, more severe clinical course of disease, and a significantly increased risk ofMolluscum contagiosum sustained skin infection
Study conducted in Croatia found a low frequency of FLG (zeige FGFR1 Proteine) null-mutations in general population (2.6%) and did not confirm FLG (zeige FGFR1 Proteine) null-mutations as an etiological factor for Atopy and Atopic disease in the studied population.
women with FLG (zeige FGFR1 Proteine) mutations may have an increased risk of AD flares during pregnancy and of enduring postpartum problems attributable to perineal trauma during delivery.
FLG (zeige FGFR1 Proteine) mutations are risk factors for atopic dermatitis in Finns, but disease severity and treatment response were independent of patient FLG (zeige FGFR1 Proteine) status.
Patients with both atopic dermatitis and common filaggrin gene mutations are more frequently affected by reduced health-related quality of life
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein