Filaggrin Proteine (FLG)

Bezeichnung:
Filaggrin Proteine (FLG)
Auf www.antikoerper-online.de finden Sie aktuell 5 Filaggrin (FLG) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Filaggrin Antikörper (131) und Filaggrin Kits (29) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 167 Filaggrin Produkte verfügbar.
Synonyme:
ATOD2, AW107830, AW208770, Eask, Fgfr-1, FLG, Flt-2, ft, Hspy, Pflg
alle Proteine anzeigen Gen GeneID UniProt
FLG 14182 P16092
FLG 2312 P20930
Ratte FLG FLG 24641  

Weitere Synonyme anzeigen

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Weitere Proteine zu Filaggrin Interaktionspartnern

Mouse (Murine) Filaggrin (FLG) Interaktionspartner

  1. CDC42 (zeige CDC42 Proteine) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.

  2. MAPK (zeige MAPK1 Proteine) cascades participate in osteogenesis, but only the ERK (zeige EPHB2 Proteine) signaling pathway responds to FGFR1 (zeige FGFR1 Proteine).

  3. It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (zeige FGFR2 Proteine) 2, in the oligodendr

  4. data suggest that FGF2 (zeige FGF2 Proteine) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Proteine) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (zeige FGFR1 Proteine), FGFR2 (zeige FGFR2 Proteine), and FGFR3 (zeige FGFR3 Proteine).

  5. increased activity of the PI3K/AKT (zeige AKT1 Proteine) signaling pathway in Pelo (zeige PELO Proteine)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation

  6. clearly demonstrate the different specificity of FGF12 (zeige FGF12 Proteine)-FGFR1c2 and FGF22 (zeige FGF22 Proteine)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling

  7. The study supports a pro-adipogenic role for betaKlotho (zeige KLB Proteine) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (zeige FGFR2 Proteine)-betaKlotho (zeige KLB Proteine) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.

  8. These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.

  9. Data suggest that Fgf1 (zeige FGF1 Proteine)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (zeige FGF1 Proteine)) and Fgfr1 (fibroblast growth factor receptor 1 (zeige FGFR1 Proteine)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (zeige LEP Proteine)).

  10. FGFR1OP2 (zeige FGFR1OP2 Proteine)-FGFR1 (zeige FGFR1 Proteine) fusion in hematopoietic stem cells induced myeloid leukemia (zeige BCL11A Proteine) and T-cell lymphoma in a mouse model.

Human Filaggrin (FLG) Interaktionspartner

  1. Patients with both atopic dermatitis and common filaggrin gene mutations are more frequently affected by reduced health-related quality of life

  2. Multiple lines of evidence suggest that FLG (zeige FGFR1 Proteine) genetic variation, have little or no effect on fitness in modern humans. Haplotype-level analysis revealed a recent selective sweep which increased the allele frequency of the Huxian haplogroup in Asian populations.

  3. FLG (zeige FGFR1 Proteine) mutations lead to alterations in epidermal eicosanoid metabolism in atopic dermatitis patients

  4. Filaggrin gene mutations are risk factors for the presence and persistence of atopic dermatitis and explain the discordance of atopic dermatitis within dizygotic twin pairs.

  5. Variations in FLG (zeige FGFR1 Proteine) and TSLP (zeige TSLP Proteine) genotype were associated with differences in self-reported skin clearance, TCI (zeige LXN Proteine) usage, and steroid usage.

  6. We show that subjects with FLG (zeige FGFR1 Proteine)-null mutations have more mature Langerhans cells in nonlesional skin irrespective of whether they have AD.

  7. we have proposed that this latitude-dependent gradient of FLG (zeige FGFR1 Proteine) mutations across Europe, Asia and Africa could have provided an evolutionary advantage for heterozygous FLG (zeige FGFR1 Proteine) mutation carriers, residing at northern latitudes, depletion of the FLG (zeige FGFR1 Proteine) downstream product, trans-urocanic acid, would facilitate the intracutaneous synthesis of vitamin D3 by allowing increased transcutaneous absorption of UVB photons

  8. The results of the present study demonstrate that filaggrin knockdown inhibits NHEK migration, adhesion and proliferation, promotes apoptosis and disturbs cell cycle progression.

  9. FLG (zeige FGFR1 Proteine) rs2065955 polymorphism was significantly related to gastric carcinoma.

  10. Four FLG (zeige FGFR1 Proteine) null mutations (3321delA, K4022X, S3296X, and S2889X) were identified in Korean patients with Atopic Dermatitis

Filaggrin (FLG) Protein Überblick

Protein Überblick

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.

Alternative names and synonyms associated with Filaggrin (FLG)

  • filaggrin (FLG)
  • filaggrin (LOC100351762)
  • fibroblast growth factor receptor 1 (Fgfr1)
  • filaggrin (Flg)
  • ATOD2 Protein
  • AW107830 Protein
  • AW208770 Protein
  • Eask Protein
  • Fgfr-1 Protein
  • FLG Protein
  • Flt-2 Protein
  • ft Protein
  • Hspy Protein
  • Pflg Protein

Bezeichner auf Proteinebene für Filaggrin Proteine (FLG)

filaggrin , MFR , bFGF-R-1 , basic fibroblast growth factor receptor 1 , c-fgr , proto-oncogene c-Fgr , epidermal filaggrin , Filaggrin (profilaggrin) , fillagrin , keratin intermediate filament-associated protein , profilaggrin

GENE ID SPEZIES
457307 Pan troglodytes
100351762 Oryctolagus cuniculus
100598645 Nomascus leucogenys
14182 Mus musculus
2312 Homo sapiens
24641 Rattus norvegicus
14246 Mus musculus
788551 Bos taurus
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