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Lpd (zeige ACSBG1 Proteine) regulates mesenchymal neu (zeige AKT1 Proteine)ral crest cell migration cell autonomously in Xeno (zeige ACSBG1 Proteine)pus laevis via the Scar/WAVE complex.
this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.
Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1 (zeige BECN1 Proteine)/Bcl-2 (zeige BCL2 Proteine) and Beclin1 (zeige BECN1 Proteine)/PI3K (zeige PIK3CA Proteine)- complex-dependent pathways.
Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 (zeige PCSK1 Proteine) cells through their interaction with the ARP2 (zeige ACTR2 Proteine)/3 complex.
we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients
a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration
A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta (zeige APP Proteine) production
D620N mutation in VPS35 (zeige vps35 Proteine) restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.
WAVE1 has unique activities independent of Arp2 (zeige ACTR2 Proteine)/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.
The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.
WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and p38MAPK (zeige MAPK14 Proteine) signaling pathways in epithelial ovarian cancer.
Scar/WAVE regulatory complex and N-WASP (zeige WASL Proteine) play opposing roles in 3D epithelial cell migration
WAVE1 phosphorylation in podocytes. Synaptopodin (zeige SYNPO Proteine) is a well-characterized target of CsA (zeige HSPA9 Proteine). WAVE1 overexpression and synaptopodin (zeige SYNPO Proteine) knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin (zeige SYNPO Proteine) expression, and vice versa
Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
Lpd (zeige ACSBG1 Proteine) directly binds active Rac (zeige AKT1 Proteine), which regulates a direct interaction between Lpd (zeige ACSBG1 Proteine) and the Scar/WAVE complex
An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 (zeige WASF2 Proteine) is for leading edge extension for directed migration in general.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology
NESH (Abi-3 (zeige ABI3 Proteine)), like Abi-1 (zeige ABI1 Proteine) and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (zeige ABL1 Proteine).
WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity.
Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
WASP family protein member 1
, homology of dictyostelium scar 1
, protein WAVE-1
, verprolin homology domain-containing protein 1
, wiskott-Aldrich syndrome protein family member 1
, WASP family 1