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we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (zeige FLT1 Proteine): sflt1 (zeige FLT1 Proteine) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (zeige FLT1 Proteine) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (zeige FLT1 Proteine) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (zeige RSPO1 Proteine) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (zeige FUT1 Proteine) specification: Wnt16 (zeige WNT16 Proteine)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (zeige TGFB1 Proteine)
Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.
altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (zeige CA2 Proteine)+) signaling responses that correlated with different cellular behaviors.
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.
noncanonical function of tars (zeige TARS Proteine) regulates vascular development presumably by modulating the expression of vegfa
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
The translation initiation factor (zeige TIF1 Proteine) eIF3i (zeige EIF3I Proteine) up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (zeige HAND1 Proteine) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 (zeige ATF6 Proteine) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
there was no distinct decrease of VEGF level in children with infantile hemangioma after propranolol treatment
MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1 (zeige FLT1 Proteine), VEGFR2 (zeige KDR Proteine), HGF (zeige HGF Proteine) and MMP2 (zeige MMP2 Proteine)
NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (zeige HIF1A Proteine)/HIF2alpha (zeige EPAS1 Proteine), VEGF/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (zeige BAX Proteine) and Bcl2 (zeige BCL2 Proteine).
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
8-Br-cAMP-induced cell-secreted VEGF is biologically active and may promote angiogenesis
VEGF expression in the RVO + panretinal photocoagulation group was strongly suppressed in both the inner nuclear and ganglion cell layers on days 7 and 14
while the genetic variations in the VEGF and MMP genes are attractive candidates as prognostic markers, our study showed no evidence of associations of a large set of SNPs in these genes and overall survival of colorectal cancer patients in our study.
miR (zeige MLXIP Proteine)-93 may participate in regulating expression of VEGF-A and contribute to the pathogenesis of arteritis in acute Kawasaki disease
Demethylation and decompression could reverse compression-induced miR (zeige MLXIP Proteine)-9 downregulation and following overexpression of miR (zeige MLXIP Proteine)-9 target genes and VEGFA.
PM2.5 exposure strongly induced the activation of the ATR (ATR (zeige ANTXR1 Proteine) serine/threonine kinase (zeige TLK2 Proteine))-CHEK1/CHK1 (checkpoint kinase 1 (zeige CHEK1 Proteine)) axis, which subsequently triggered TP53 (zeige TP53 Proteine)-dependent autophagy and VEGFA production in Beas-2B cells.
results suggested that the combination of nCS (to support bone formation) with a fibrin-based VEGF/FGF9 release system (support vascular formation) is an innovative and effective strategy that significantly enhanced ectopic bone formation in vivo.
Astrocyte-derived vascular endothelial growth factor-A (VEGF-A) is known to induce BBB dysfunction.(review)
CRP (zeige CRP Proteine) can upregulate vascular endothelial growth factor-A (VEGF-A) expression by activating hypoxia inducible factor-1alpha (HIF-1alpha (zeige HIF1A Proteine)) in ADSCs.
VEGF and IGF1 (zeige IGF1 Proteine) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling was involved in the role of VEGF and IGF1 (zeige IGF1 Proteine).
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK (zeige MAPK14 Proteine) stress pathway following VEGF-A antagonism have been documented.
The neuroprotection observed in ColXV KO mice may be attributed to the increased VEGF-A production following stroke in the ischemic territory.
VEGF protein levels were also higher in the ipsilateral hemisphere of WT mice compared to Par-1 (zeige MARK2 Proteine) KO mice after glioma cell implantation.
the importance of VEGF derived from tumor-infiltrating myeloid cells for initiating vascularization in gliomas
Low VEGF expression is associated with liver fibrosis.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (zeige NOTCH1 Proteine) signaling.
interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (zeige HIF1A Proteine).
data shows that members of the VEGF-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (zeige ANGPT1 Proteine) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion
TNF (zeige TNF Proteine) may up-regulate VEGF and stimulate angiogenesis in the mare (zeige C16orf35 Proteine) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (zeige KLHL2 Proteine)) and expression of VEGF and MVD (zeige MVD Proteine) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (zeige MMP9 Proteine) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).
VEGF induces TGF-beta1 (zeige TGFB1 Proteine) expression and myofibroblast transformation after glaucoma surgery.
The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis
The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (zeige CXCR4 Proteine), and TGFB1 (zeige TGFB1 Proteine) expression and inhibiting choroidl endothelial cell proliferation.
Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (zeige MMP9 Proteine) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF