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VEGF Proteine (VEGFA)

Bezeichnung:
Vascular Endothelial Growth Factor A Proteine (VEGFA)
Auf www.antikoerper-online.de finden Sie aktuell 130 Vascular Endothelial Growth Factor A (VEGFA) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VEGF Antikörper (361) und VEGF Kits (115) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 624 VEGF Produkte verfügbar.
Synonyme:
eVEGF120, eVEGF164, MVCD1, vefg, Vegf, VEGF-A, Vegf120, VEGF164, Vegf188, vegfa, Vpf, wu:fj82c06
alle Proteine anzeigen Gen GeneID UniProt
VEGFA 7422 P15692
VEGFA 22339 Q00731
VEGFA 83785 P16612

Weitere Synonyme anzeigen

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Am meisten referenzierte VEGF Proteine

  1. Rat (Rattus) VEGF Protein expressed in HEK-293 - ABIN2666575 : Martin, Galisteo, Gutkind et al.: CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) ... in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 7 Referenzen für ABIN2666575

  2. Mouse (Murine) VEGF Protein expressed in HEK-293 - ABIN2666680 : Koch, Claesson-Welsh: Signal transduction by vascular endothelial growth factor receptors. in Cold Spring Harbor perspectives in medicine 2012 (PubMed)
    Zeige alle 6 Referenzen für ABIN2666680

  3. Human VEGF Protein expressed in Human Cells - ABIN2003877 : Zachary, Gliki: Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. in Cardiovascular research 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN2003877

  4. Rat (Rattus) VEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2009015 : Robinson, Stringer: The splice variants of vascular endothelial growth factor (VEGF) and their receptors. in Journal of cell science 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN2009015

Weitere Proteine zu VEGF Interaktionspartnern

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

  2. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

  3. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (zeige CA2 Proteine)+) signaling responses that correlated with different cellular behaviors.

  4. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

  5. noncanonical function of tars (zeige TARS Proteine) regulates vascular development presumably by modulating the expression of vegfa

  6. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  7. The translation initiation factor (zeige TIF1 Proteine) eIF3i (zeige EIF3I Proteine) up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

  8. lack of SULF1 (zeige SULF1 Proteine) expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 (zeige SULF1 Proteine) mediates arterial specification by regulating VegfA165 activity.

  9. yolk-derived 17beta-estradiol sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF.

  10. Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

  2. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

  3. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

  4. increased VEGF(170) levels disturb Hand-1 (zeige HAND1 Proteine) expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

  3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

  4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

  5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 (zeige ATF6 Proteine) arms of the unfolded protein response compared with untreated cells.

  6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

  7. VEGF supports germ cell survival and sperm production in bulls.

  8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

  9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

  10. Alterations in the expression of VEGF-A and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Human Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. The VEGFA T allele in SNPs rs833070 and rs3025020 may confer a protective effect to chronic obstructive pulmonary disease in a Spanish population. The association of the VEGFA SNP rs3025020 with lung function is suggestive of a role for VEGFA in the progression of the disease.

  2. Combined cytotoxic therapy and targeted anti-VEGF therapy for colorectal adenocarcinoma metastases to the liver leads to some suppression of the alternative pathway in the formation of new vessels, by reducing the expression of CXCR4 in the vessel endothelial cells and that of VEGF in the stromal cells from the metastatic foci

  3. This study confirms the contribution of altered VEGF secretion, resulting from genetic variation in VEGFA gene into the pathogenesis of pathogenesis of polycystic ovary syndrome.

  4. HuR (zeige ELAVL1 Proteine) plays important roles in determining malignant aggressiveness and outcome in prostate cancer (PCa (zeige FLVCR1 Proteine)), especially in androgen-independent PCa (zeige FLVCR1 Proteine) cells, via the regulation of cell proliferation, migration, and expression of VEGF-A, -C, and COX-2.

  5. direct-acting antivirals administration induces an early increase in serum VEGF and a change in the inflammatory pattern, coinciding with HCV clearance. This may alter the balance between inflammatory and anti-inflammatory processes and modify the antitumor surveillance of the host.

  6. this study shows that 1,25(OH)2D3 can alleviate house dust mite-induced airway epithelial barrier dysfunction by inhibiting PI3K pathway-dependent VEGF release

  7. MicroRNA-29b inhibits angiogenesis by targeting VEGFA through the MAPK/ERK (zeige MAPK1 Proteine) and PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathways in endometrial carcinoma.

  8. Our results show a miRNA editing activity trend aligning with cellular pathways closely associated to hypoxia, such as the VEGF and PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathways, providing important novel insights on this poorly elucidated phenomenon.

  9. Patients with post-peripartum cardiomyopathy have significantly higher plasma sFlt1 (zeige FLT1 Proteine) concentration with a trend of somewhat higher levels of VEGF and significantly decreased VEGF/sFlt1 (zeige FLT1 Proteine) ratio compared to controls.

  10. ANRIL regulates VEGF expression and function in diabetic retinopathy. This regulation is mediated by p300 (zeige EP300 Proteine), miR200b, and EZH2 (zeige EZH2 Proteine) of the PRC2 complex.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. findings demonstrated that a multi-component Chinese medicine DHI effectively increased blood flow recovery after tissue ischemia in diabetic mice by promoting angiogenesis and improving glucose tolerance through a concomitant activation of VEGF-A/VEGFR-2 (zeige KDR Proteine) and PPARdelta (zeige PPARD Proteine) signaling pathways

  2. MicroRNA-29b inhibits angiogenesis by targeting VEGFA through the MAPK/ERK (zeige MAPK1 Proteine) and PI3K/Akt (zeige AKT1 Proteine) signaling pathways in endometrial carcinoma.

  3. Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF) expression is up-regulated after choroidal neovascularization (CNV) formation.

  4. beta2-AR activation also stimulated VEGF and IL-6 (zeige IL6 Proteine) mRNA expression by 2- and 10-fold, respectively.

  5. XBP1 regulates VEGF-mediated cardiac angiogenesis.

  6. First-in-class selective PET tracers for imaging VEGFR-1 (zeige FLT1 Proteine) and VEGFR-2 (zeige KDR Proteine) were constructed and successfully validated in an orthotopic murine tumor model.

  7. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  8. The results demonstrate that the Vegf-Dll4 (zeige DLL4 Proteine)/Notch (zeige NOTCH1 Proteine) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.

  9. Ginkgo biloba exocarp extract inhibits tumor angiogenesis, which may be closely relevant to its effect in blockage of Wnt /beta-catenin-VEGF signaling pathway in Lewis lung carcinoma.

  10. D2R agonist treatment blocks tumor growth, induces regression of the aberrant blood supply and normalizes blood vessels. An anti-Vegf therapy is also effective to restrain tumor growth and improves vascular remodeling. Importantly, only the combination treatment suppresses intratumoral hemorrhage and restores blood vessel perfusion, suggesting that it might represent an attractive therapy targeting tumor vasculature

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. Here we demonstrate that VEGF-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

  2. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

  3. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

  4. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (zeige NOTCH1 Proteine) signaling.

  5. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

  6. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (zeige HIF1A Proteine).

  7. data shows that members of the VEGF-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  8. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (zeige ANGPT1 Proteine) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

  9. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.

  10. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1 (zeige FLT1 Proteine), VEGFR2 (zeige KDR Proteine) and Neuropilin-1 (zeige NRP1 Proteine) and -2 mRNAs.

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

  2. TNF (zeige TNF Proteine) may up-regulate VEGF and stimulate angiogenesis in the mare (zeige C16orf35 Proteine) early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

  2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

  2. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (zeige KLHL2 Proteine)) and expression of VEGF and MVD (zeige MVD Proteine) in tumor tissue

  3. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

  4. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  5. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (zeige MMP9 Proteine) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

  6. VEGF expression peaked at 8 weeks after meniscus transplantation

  7. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

  8. VEGF induces TGF-beta1 (zeige TGFB1 Proteine) expression and myofibroblast transformation after glaucoma surgery.

  9. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

  10. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

  2. These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (zeige CXCR4 Proteine), and TGFB1 (zeige TGFB1 Proteine) expression and inhibiting choroidl endothelial cell proliferation.

  3. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

  4. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

  5. A functional network involving VEGF, IGF2, and MMP9 (zeige MMP9 Proteine) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.

VEGF (VEGFA) Protein Überblick

Protein Überblick

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Alternative names and synonyms associated with VEGF (VEGFA)

  • vascular endothelial growth factor Aa (vegfaa)
  • vascular endothelial growth factor A (vegfa-a)
  • vascular endothelial growth factor A (VEGFA)
  • vascular endothelial growth factor A (vegfa)
  • vascular endothelial growth factor A (Vegfa)
  • eVEGF120 Protein
  • eVEGF164 Protein
  • MVCD1 Protein
  • vefg Protein
  • Vegf Protein
  • VEGF-A Protein
  • Vegf120 Protein
  • VEGF164 Protein
  • Vegf188 Protein
  • vegfa Protein
  • Vpf Protein
  • wu:fj82c06 Protein

Bezeichner auf Proteinebene für VEGFA

VEGF-A-A , etID309976.16 , vascular endothelial growth factor A , vascular endothelial growth factor A-A , vegf-a , vascular endothelial growth factor A-a , vascular endothelial growth factor 164 , vascular permeability factor , VEGF-A , VPF , vascular endothelial growth factor 188 , angiogenic factor , Vascular permeability factor , endothelial growth factor-164 , vascular endothelial growth factor VEGF

GENE ID SPEZIES
30682 Danio rerio
373589 Xenopus laevis
493845 Felis catus
100038089 Xenopus (Silurana) tropicalis
281572 Bos taurus
7422 Homo sapiens
22339 Mus musculus
83785 Rattus norvegicus
397157 Sus scrofa
403802 Canis lupus familiaris
395909 Gallus gallus
100033839 Equus caballus
443103 Ovis aries
100713483 Cavia porcellus
100860957 Capra hircus
100008899 Oryctolagus cuniculus
101839822 Mesocricetus auratus
574209 Macaca mulatta
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