VEGF Proteine (VEGFA)

Bezeichnung:
Vascular Endothelial Growth Factor A Proteine (VEGFA)
Auf www.antikoerper-online.de finden Sie aktuell 149 Vascular Endothelial Growth Factor A (VEGFA) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VEGF Antikörper (389) und VEGF Kits (118) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 674 VEGF Produkte verfügbar.
Synonyme:
eVEGF120, eVEGF164, MVCD1, vefg, Vegf, VEGF-A, Vegf120, VEGF164, Vegf188, vegfa, Vpf, wu:fj82c06
alle Proteine anzeigen Gen GeneID UniProt
VEGFA 7422 P15692
VEGFA 22339 Q00731
VEGFA 83785 P16612

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Am meisten referenzierte VEGF Proteine

  1. Rat (Rattus) VEGF Protein expressed in HEK-293 - ABIN2666575 : Martin, Galisteo, Gutkind et al.: CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) ... in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 7 Referenzen für 2666575

  2. Mouse (Murine) VEGF Protein expressed in HEK-293 - ABIN2666680 : Koch, Claesson-Welsh: Signal transduction by vascular endothelial growth factor receptors. in Cold Spring Harbor perspectives in medicine 2012 (PubMed)
    Zeige alle 6 Referenzen für 2666680

  3. Human VEGF Protein expressed in Human Cells - ABIN2003877 : Zachary, Gliki: Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. in Cardiovascular research 2001 (PubMed)
    Zeige alle 2 Referenzen für 2003877

  4. Rat (Rattus) VEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2009015 : Robinson, Stringer: The splice variants of vascular endothelial growth factor (VEGF) and their receptors. in Journal of cell science 2001 (PubMed)
    Zeige alle 2 Referenzen für 2009015

Weitere Proteine zu VEGF Interaktionspartnern

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. Rspo1 (zeige RSPO1 Proteine) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (zeige FUT1 Proteine) specification: Wnt16 (zeige WNT16 Proteine)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (zeige TGFB1 Proteine)

  2. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

  3. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

  4. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (zeige CA2 Proteine)+) signaling responses that correlated with different cellular behaviors.

  5. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

  6. noncanonical function of tars (zeige TARS Proteine) regulates vascular development presumably by modulating the expression of vegfa

  7. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  8. The translation initiation factor (zeige TIF1 Proteine) eIF3i (zeige EIF3I Proteine) up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

  9. lack of SULF1 (zeige SULF1 Proteine) expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 (zeige SULF1 Proteine) mediates arterial specification by regulating VegfA165 activity.

  10. yolk-derived 17beta-estradiol sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

  2. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

  3. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

  4. increased VEGF(170) levels disturb Hand-1 (zeige HAND1 Proteine) expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

  3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

  4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

  5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 (zeige ATF6 Proteine) arms of the unfolded protein response compared with untreated cells.

  6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

  7. VEGF supports germ cell survival and sperm production in bulls.

  8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

  9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

  10. Alterations in the expression of VEGF-A and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Human Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. This study shows that expression of SDF-1alpha, eNOS (zeige NOS3 Proteine) and VEGF were significantly higher in uterine leiomyoma than myometrium with a different expression pattern according to the size of uterine leiomyoma. However, expressions of visfatin (zeige NAMPT Proteine) and leptin (zeige LEP Proteine) had no significant differences between the two groups.

  2. VitD supplementation decreases serum VEGF levels correlating with a decrease in triglycerides in women with polycystic ovary syndrome.

  3. Net1 promotes the angiogenesis in cervical squamous cell carcinomas and siRNA targeting of Net1 can effectively reduce angiogenesis and inhibit tumor growth via VEGF signaling.

  4. This meta-analysis showed that VEGF SNP rs1570360 (especially in Caucasians) and rs3025039 (especially in East Asians) may be risk factors for recurrent pregnancy loss.

  5. High expression of VEGFA is associated with squamous cell lung carcinoma.

  6. Tanshinone IIA inhibits beta-catenin (zeige CTNNB1 Proteine)/VEGF-mediated angiogenesis by targeting TGF-beta1 (zeige TGFB1 Proteine) in normoxic and HIF-1alpha (zeige HIF1A Proteine) in hypoxic microenvironments in human colorectal cancer.

  7. Authors found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.

  8. Report up-regulation of the mTOR, PDGF, VEGF, and c-kit pathways in a large cohort of Kaposi sarcoma samples.

  9. circRNA-MYLK (zeige MYLK Proteine) might function as competing endogenous RNA for miR (zeige MLXIP Proteine)-29a, which could contribute to empithelial-mesenchymal transformation and the development of bladder cancer by activating VEGFA/VEGFR2 (zeige KDR Proteine) and downstream Ras/ERK (zeige EPHB2 Proteine) signaling pathway.

  10. miR-377 regulated CD133 and VEGF by directly binding to their 3' untranslated region.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. This study identifies YAP/TAZ as central mediators of VEGF signaling

  2. Ectopic midline vascularisation in endothelial Nrp1 (zeige NRP1 Proteine) and Vegfa(188/188) mutants caused additional axonal exclusion zones within the chiasm.

  3. RUNX1T1 (zeige RUNX1T1 Proteine) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. VEGF inhibition decreases local CFH (zeige CFH Proteine) and other complement regulators in the eye and kidney through reduced VEGFR2 (zeige KDR Proteine)/PKC-alpha (zeige PKCa Proteine)/CREB (zeige CREB1 Proteine) signaling.

  5. Vascular endothelial growth factor (VEFG)-A, originally described as an angiogenic factor, belongs to a super-family of glycoproteins, and signals through tyrosine kinase (zeige TYRO3 Proteine) receptors VEGF receptor (zeige FLT1 Proteine) 1 (VEGFR1 (zeige FLT1 Proteine)) and VEGF receptor 2 (VEGFR2) and coreceptors, neuropilin (NP) 1 (zeige NRP1 Proteine) and 2.

  6. VEGF-A overexpression in adipocytes triggers angiogenesis. There was a rapid appearance of beige fat cells in subcutaneous white adipose tissue as early as 2 days postinduction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A-induced beiging is independent of interleukin-4 (zeige IL4 Proteine).

  7. Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A/VEGFR-2 (zeige KDR Proteine) signaling and suggest that VEGFR-2 (zeige KDR Proteine)-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.

  8. VEGFR3 (zeige FLT4 Proteine) limits VEGFR2 (zeige KDR Proteine) expression and VEGF/VEGFR2 (zeige KDR Proteine) pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.

  9. VEGF165-induced vascular leakage requires both VEGFR2 (zeige KDR Proteine) and NRP1 (zeige NRP1 Proteine), including the VEGF164-binding site of NRP1 (zeige NRP1 Proteine) and the NRP1 (zeige NRP1 Proteine) cytoplasmic domain (NCD), but not the known NCD interactor GIPC1 (zeige GIPC1 Proteine).

  10. Apelin could effectively promote mesenchymal stem cell survival and vascularization under hypoxic-ischemic condition in vitro, and this procedure was associated with the upregulation of VEGF.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

  2. results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility

  3. Here we demonstrate that VEGF-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

  4. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

  5. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

  6. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (zeige NOTCH1 Proteine) signaling.

  7. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

  8. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (zeige HIF1A Proteine).

  9. data shows that members of the VEGF-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  10. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (zeige ANGPT1 Proteine) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

  2. TNF (zeige TNF Proteine) may up-regulate VEGF and stimulate angiogenesis in the mare (zeige C16orf35 Proteine) early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

  2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

  2. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (zeige KLHL2 Proteine)) and expression of VEGF and MVD (zeige MVD Proteine) in tumor tissue

  3. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

  4. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  5. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (zeige MMP9 Proteine) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

  6. VEGF expression peaked at 8 weeks after meniscus transplantation

  7. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

  8. VEGF induces TGF-beta1 (zeige TGFB1 Proteine) expression and myofibroblast transformation after glaucoma surgery.

  9. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

  10. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

  1. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

  2. These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (zeige CXCR4 Proteine), and TGFB1 (zeige TGFB1 Proteine) expression and inhibiting choroidl endothelial cell proliferation.

  3. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

  4. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

  5. A functional network involving VEGF, IGF2, and MMP9 (zeige MMP9 Proteine) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.

VEGF (VEGFA) Protein Überblick

Protein Überblick

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Alternative names and synonyms associated with VEGF (VEGFA)

  • vascular endothelial growth factor Aa (vegfaa)
  • vascular endothelial growth factor A (vegfa-a)
  • vascular endothelial growth factor A (VEGFA)
  • vascular endothelial growth factor A (vegfa)
  • vascular endothelial growth factor A (Vegfa)
  • eVEGF120 Protein
  • eVEGF164 Protein
  • MVCD1 Protein
  • vefg Protein
  • Vegf Protein
  • VEGF-A Protein
  • Vegf120 Protein
  • VEGF164 Protein
  • Vegf188 Protein
  • vegfa Protein
  • Vpf Protein
  • wu:fj82c06 Protein

Bezeichner auf Proteinebene für VEGFA

VEGF-A-A , etID309976.16 , vascular endothelial growth factor A , vascular endothelial growth factor A-A , vegf-a , vascular endothelial growth factor A-a , vascular endothelial growth factor 164 , vascular permeability factor , VEGF-A , VPF , vascular endothelial growth factor 188 , angiogenic factor , Vascular permeability factor , endothelial growth factor-164 , vascular endothelial growth factor VEGF

GENE ID SPEZIES
30682 Danio rerio
373589 Xenopus laevis
493845 Felis catus
100038089 Xenopus (Silurana) tropicalis
281572 Bos taurus
7422 Homo sapiens
22339 Mus musculus
83785 Rattus norvegicus
397157 Sus scrofa
403802 Canis lupus familiaris
395909 Gallus gallus
100033839 Equus caballus
443103 Ovis aries
100713483 Cavia porcellus
100860957 Capra hircus
100008899 Oryctolagus cuniculus
101839822 Mesocricetus auratus
574209 Macaca mulatta
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