RASGRF1 Proteine (RASGRF1)

Bezeichnung:
Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 Proteine (RASGRF1)
Auf www.antikoerper-online.de finden Sie aktuell 4 Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RASGRF1 Antikörper (92) und RASGRF1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 108 RASGRF1 Produkte verfügbar.
Synonyme:
AI844718, cdc25, CDC25L, CDC25Mm, GNRP, Grf1, GRF55, Grfbeta, H-GRF55, p190, P190-A, p190RhoGEF, PP13187, PPP1R60, Ras-GRF1, rasgrf1
alle Proteine anzeigen Gen GeneID UniProt
RASGRF1 995 P30307
RASGRF1 19417 P27671
Ratte RASGRF1 RASGRF1 192213 P28818

Weitere Synonyme anzeigen

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Weitere Proteine zu RASGRF1 Interaktionspartnern

Human Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Interaktionspartner

  1. Myelodysplastic syndrome -related P95 (zeige NBN Proteine) point mutants of SRSF2 (zeige SRSF2 Proteine) lead to alternative splicing of CDC25C (zeige CDC25C Proteine) in a manner that is not dependent on the DNA damage response.

  2. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (zeige PPP2R4 Proteine), CDC25 and DUSP1 (zeige DUSP1 Proteine)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

  3. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.

  4. Data show that TRIB2 (zeige TRIB2 Proteine)-mediated degradation of CDC25C (zeige CDC25C Proteine) is associated with lysine-48-linked CDC25C (zeige CDC25C Proteine) polyubiquitination driven by the TRIB2 (zeige TRIB2 Proteine) kinase-like domain.

  5. the biology of the activation/deactivation of CDC25 by kinases/phosphatases to maintain the level of CDK (zeige CDK4 Proteine)-cyclin (zeige PCNA Proteine) activities and thus the genomic stability

  6. Data show that microRNA miR (zeige MLXIP Proteine)-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression.

  7. the knockdown of CDC25C (zeige CDC25C Proteine) can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.

  8. results identify CDC25C (zeige CDC25C Proteine) as a downstream target of the mutated tyrosine kinase (zeige TXK Proteine) FLT3 (zeige FLT3 Proteine)-ITD affecting cell-cycle regulation in a model of AML (zeige RUNX1 Proteine)

  9. Suggest that the p53-p21-DREAM-CDE/CHR pathway regulates p53-dependent repression of Survivin, CDC25C, and PLK1 in HCT116 cells.

  10. Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.

Mouse (Murine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Interaktionspartner

  1. Novel mercaptoacetamide-based class II histone deacetylase (zeige HDAC1 Proteine) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK (zeige EPHB2 Proteine), and that W2 requires RasGRF1 and ERK (zeige EPHB2 Proteine) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK (zeige EPHB2 Proteine)-dependent signaling pathway

  2. Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.

  3. VLDLR (zeige VLDLR Proteine) requires RasGRF1/CaMKII (zeige CAMK2G Proteine) to alter dendritic spine formation.

  4. Study suggests a complex role of ERK (zeige EPHB2 Proteine)-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals

  5. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 (zeige PTTG1 Proteine) expression and controlling beta cell development and physiological responses.

  6. CARD9 (zeige CARD9 Proteine) regulates H-Ras (zeige HRAS Proteine) activation by linking Ras-GRF1 to H-Ras (zeige HRAS Proteine), which mediates Dectin-1 (zeige CLEC7A Proteine)-induced extracellular signal-regulated protein kinase (zeige CDK7 Proteine) (ERK (zeige EPHB2 Proteine)) activation and proinflammatory responses when stimulated by their ligands.

  7. GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.

  8. Data indicate that contextual discrimination involves term potentiation (LTP (zeige SCP2 Proteine)) promoted by calcium-permeable AMPA (zeige GRIA3 Proteine)-type glutamate (zeige GRIN1 Proteine) receptors, RAS-GRF1 and p38 MAP kinase (zeige MAPK14 Proteine).

  9. Ras-GRF1 and -GRF2 (zeige RASGRF2 Proteine) may act as adaptors that bind PLCgamma1 (zeige PLCG1 Proteine) and restrict Ca2 (zeige CA2 Proteine)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (zeige IL1A Proteine) induction of the Ras-->ERK (zeige EPHB2 Proteine) pathway and MMP-3 (zeige MMP3 Proteine) expression

  10. identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 (zeige PLAGL1 Proteine) target gene in beta cells

Pig (Porcine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Interaktionspartner

  1. In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.

RASGRF1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with RASGRF1

  • Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1)
  • si:ch211-234p18.3 (si:ch211-234p18.3)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (rasgrf1)
  • cell division cycle 25C (CDC25C)
  • RAS protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • AI844718 Protein
  • cdc25 Protein
  • CDC25L Protein
  • CDC25Mm Protein
  • GNRP Protein
  • Grf1 Protein
  • GRF55 Protein
  • Grfbeta Protein
  • H-GRF55 Protein
  • p190 Protein
  • P190-A Protein
  • p190RhoGEF Protein
  • PP13187 Protein
  • PPP1R60 Protein
  • Ras-GRF1 Protein
  • rasgrf1 Protein

Bezeichner auf Proteinebene für RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 , ras-specific guanine nucleotide-releasing factor 1-like , M-phase inducer phosphatase 3 , dual specificity phosphatase CDC25C , mitosis inducer CDC25 , phosphotyrosine phosphatase , protein phosphatase 1, regulatory subunit 60 , Ras-specific guanine nucleotide-releasing factor, CDC25 homolog , Ras-specific nucleotide exchange factor CDC25 , guanine nucleotide exchange factor , guanine nucleotide-releasing factor 1 , guanine nucleotide-releasing factor, 55 kD , guanine nucleotide-releasing protein , ras-specific guanine nucleotide-releasing factor 1 , GNRP , GRF beta , Ras guanine release factor beta , guanine nucleotide releasing factor 1 , ras-specific nucleotide exchange factor CDC25 , P140 RAS-GRF , ras-GRF1

GENE ID SPEZIES
453575 Pan troglodytes
568885 Danio rerio
100014099 Monodelphis domestica
100050202 Equus caballus
100461675 Pongo abelii
100479998 Ailuropoda melanoleuca
100492267 Xenopus (Silurana) tropicalis
995 Homo sapiens
5923 Homo sapiens
19417 Mus musculus
192213 Rattus norvegicus
494866 Xenopus laevis
488774 Canis lupus familiaris
520039 Bos taurus
415578 Gallus gallus
100157221 Sus scrofa
100731687 Cavia porcellus
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