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Phospholipase D2 Proteine (PLD2)

Bezeichnung:
Phospholipase D2 Proteine (PLD2)
Auf www.antikoerper-online.de finden Sie aktuell 4 Phospholipase D2 (PLD2) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Phospholipase D2 Antikörper (52) und Phospholipase D2 Kits (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 81 Phospholipase D2 Produkte verfügbar.
Synonyme:
PLD2, Pldc
alle Proteine anzeigen Gen GeneID UniProt
PLD2 5338 O14939
Ratte PLD2 PLD2 25097 P70498
PLD2 18806 P97813

Weitere Synonyme anzeigen

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Weitere Proteine zu Phospholipase D2 Interaktionspartnern

Human Phospholipase D2 (PLD2) Interaktionspartner

  1. Data suggest that elevated membrane tension acts through phospholipase D2 (PLD2) and the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 2 (mTORC2 (zeige CRTC2 Proteine)) to limit actin nucleation.

  2. results suggest that the small GTPase (zeige RACGAP1 Proteine) RalA (zeige rala Proteine) plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (zeige CAV1 Proteine) and FilA but by stimulating PLD2-mediated generation of phosphatidic acid.

  3. Suggest PLD expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance.

  4. PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.

  5. PLD2 protein itself interacts with HIF-1alpha (zeige HIF1A Proteine), prolyl hydroxylase (PHD (zeige PDC Proteine)) and VHL (zeige VHL Proteine) to promote degradation of HIF-1alpha (zeige HIF1A Proteine) via the proteasomal pathway independent of lipase (zeige LIPG Proteine) activity.

  6. PLD2-mediated production of phosphatidic acid contributed to the control of EGFR (zeige EGFR Proteine) exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR (zeige EGFR Proteine) signaling in cancer cells.

  7. These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha (zeige HIF1A Proteine) in response to hypoxic stress and underscores the crucial role of HIF1-alpha (zeige HIF1A Proteine)-induced PLD2 in tumor growth.

  8. A 3D model of the PLD2 by combining homology and ab initio 3 dimensional structural modeling methods, and docking conformation, is reported.

  9. PLD2 expression regulates formation of Golgi tubules in Hela cells.

  10. Results indicate distinctive roles of phospholipase D PLD1 and PLD2 isoforms in pathological conditions in retinal pigment epithelium (RPE).

Cow (Bovine) Phospholipase D2 (PLD2) Interaktionspartner

  1. Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.

Mouse (Murine) Phospholipase D2 (PLD2) Interaktionspartner

  1. PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.

  2. PLD1/2 signaling pathways are involved in mitogenic signaling in astrocytes.

  3. Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways.

  4. PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis

  5. The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated.

  6. AQP3 (zeige AQP3 Proteine) has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect.

  7. phosphatidic acid and phospholipase D1 and D2 have roles in leukocyte adhesion

  8. PLD1 and PLD2 have roles in platelet alpha-granule secretion

  9. Demonstrate a novel role for endothelial PLD2 in the survival and migration of ECs under hypoxia via the expression of hypoxia-inducible factor-1alpha and in pathological retinal angiogenesis and tumor angiogenesis in vivo.

  10. Pharmacological PLD inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and ischemic stroke.

Pig (Porcine) Phospholipase D2 (PLD2) Interaktionspartner

  1. The results indicate that PKC (zeige FYN Proteine) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (zeige AGT Proteine).

Phospholipase D2 (PLD2) Protein Überblick

Protein Überblick

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Phospholipase D2 (PLD2)

  • phospholipase D2 (PLD2)
  • phospholipase D2 (pld2)
  • phospholipase D2 (CpipJ_CPIJ013122)
  • phospholipase D2 (VDBG_00892)
  • phospholipase D2 (Pld2)
  • PLD2 Protein
  • Pldc Protein

Bezeichner auf Proteinebene für Phospholipase D2 Proteine (PLD2)

phospholipase D2 , phospholipase D2-like , PLD1C , choline phosphatase 2 , hPLD2 , phosphatidylcholine-hydrolyzing phospholipase D2 , PLD 2 , phospholipase D gene 2 , rPLD2 , mPLD2

GENE ID SPEZIES
454454 Pan troglodytes
479473 Canis lupus familiaris
565743 Danio rerio
721573 Macaca mulatta
6045991 Culex quinquefasciatus
9530787 Verticillium alfalfae VaMs.102
100391217 Callithrix jacchus
100457163 Pongo abelii
100477588 Ailuropoda melanoleuca
100601695 Nomascus leucogenys
5338 Homo sapiens
522159 Bos taurus
25097 Rattus norvegicus
18806 Mus musculus
414900 Sus scrofa
100721224 Cavia porcellus
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