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significant correlations between DNA methylation (zeige HELLS Proteine) of the PDGFD gene promoter and the risk of developing either IA or BAVM
This study suggested that epithelial-mesenchymal transition process can be triggered by the PDGF-D/PDGFRb (zeige PDGFRB Proteine) axis in tongue squamous cell carcinoma, and then involved in the tumor cell invasion via activation of p38 (zeige CRK Proteine)/AKT (zeige AKT1 Proteine)/ERK (zeige EPHB2 Proteine)/ epithelial-mesenchymal transition pathway.
No specific genotype of rs974819 of Platelet-derived growth factor D demonstrated increased cardiovascular mortality in the total population, however, the male group with genotypes A/A and G/A demonstrated an increased risk that persisted in a multivariate evaluation where adjustments were made for well-known cardiovascular risk factors.
There are four platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) genes (PDGFA (zeige PDGFA Proteine), PDGFB (zeige PDGFB Proteine), PDGFC (zeige PDGFC Proteine) and PDGFD) that reside on chromosomes 7, 22, 4 and 11.
polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population
Novel findings reveal a new paradigm in matriptase (zeige ST14 Proteine) activation involving PDGF-D-specific signal transduction leading to extracellular acidosis.
PDGF-D expression is associated with miR (zeige MLXIP Proteine)-106a and Twist1 (zeige TWIST1 Proteine) in HCC (zeige FAM126A Proteine) patients
PDGF-D is highly expressed by ASCs, where it acts as a potent mitogenic factor.
PDGFD, CDH1 and SLIT2 are upregulated in low grade meningiomas and schwannomas compared with healthy tissue.
PDGF (zeige PDGFA Proteine)-DD secreted by gastric cancer derived mesenchymal stem cells is capable of promoting gastric cancer cell progression in vitro and in vivo.
Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health.
PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1 (zeige TIMP1 Proteine)/MMP-2 (zeige MMP2 Proteine)/MMP (zeige MMP2 Proteine)-9 (zeige MMP9 Proteine) system, and PDGF-D signaling is mediated through both PDGF (zeige PDGFA Proteine)-alpha and -beta receptors.
Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex
PDGF D represents a potentially promising target for prostate carcinoma treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study.
Data indicate that the proteolytic processing of full-length PDGF-D is required for PDGF-D activation of preosteoclasts, and that beta-PDGFR (zeige PDGFRB Proteine) is present in activated osteoclasts.
identified PDGF (zeige PDGFA Proteine)-DD as an important target gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells. PDGF (zeige PDGFA Proteine)-DD inhibition may offer new therapeutic options to treat neovascular diseases
Failure of laminin alpha4-mediated down-regulation of PDGF (zeige PDGFA Proteine) activity contributes to the progressive renal lesions in this animal model.
These results suggest that PDGF-D induce cellular transformation and promote tumour growth by accelerating the proliferation rate of the tumour cells, and by stimulation of tumour neovascularization.
PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF (zeige PDGFA Proteine)-Rbeta in obstructive ureteral nephropathy
PDGF (zeige PDGFA Proteine)-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.
, iris-expressed growth factor
, platelet-derived growth factor D
, spinal cord derived growth factor B
, spinal cord-derived growth factor B
, spinal cord-derived growth factor-B
, platelet-derived growth factor, D polypeptide
, spinal-cord derived growth factor-B protein
, platelet derived growth factor D
, platelet-derived growth factor D-like