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Human PDGFB Protein expressed in HEK-293 Cells - ABIN2181626
Chen, Cai, Zhang, Liu, Liu: Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. in Experimental and therapeutic medicine 2014
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High PDGFB expression is associated with gastric cancer.
We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (zeige DMD Proteine) patients expressed PDGF (zeige PDGFA Proteine)-BB.
Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma (zeige MOK Proteine).
Insulin (zeige INS Proteine) treatment caused sustained Akt (zeige AKT1 Proteine) activity, whereas EGF (zeige EGF Proteine) or PDGF (zeige PDGFA Proteine)-AA promoted transient signaling; PDGF (zeige PDGFA Proteine)-BB produced sustained responses at higher concentrations.Transient responses to EGF (zeige EGF Proteine) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (zeige IGF1 Proteine) caused full Akt (zeige AKT1 Proteine) activation
high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.
High PDGFB expression is associated with glioma.
A cell-autonomous positive-signaling circuit is associated with the PDGF (zeige PDGFA Proteine)-NO-ID4 (zeige ID4 Proteine)-regulatory axis in glioblastoma cells.
SphK1 (zeige SPHK1 Proteine) is regulated by PDGF (zeige PDGFA Proteine)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (zeige EGR1 Proteine), promoting cell proliferation.
PDGF (zeige PDGFA Proteine)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.
Low concentration of PDGF (zeige PDGFA Proteine)-AB showed synergism with IFN-alpha (zeige IFNA Proteine) in IFN-beta (zeige IFNB1 Proteine) and -gamma induction.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (zeige AKT1 Proteine)/Stat3 (zeige STAT3 Proteine) signaling pathway.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (zeige AGT Proteine)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (zeige ROS1 Proteine), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (zeige VEGFA Proteine), FGF-2 (zeige FGF2 Proteine) and PDGF (zeige PDGFA Proteine)-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa (zeige PDGFA Proteine) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB (zeige PDGFRB Proteine) cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 (zeige PAX3 Proteine) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Increased expression of STAT5b (zeige STAT5B Proteine) + PDGFB led to increased expression of downstream STAT5b (zeige STAT5B Proteine) targets.
Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (zeige ABCB4 Proteine)-null mice.
The endogenous levels of PDGF (zeige PDGFA Proteine)-BB, increases CD31 (zeige PECAM1 Proteine)(hi)endomucin (zeige EMCN Proteine)(hi) vessel number and stimulates bone formation in ovariectomy mice.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit