PDGFB Proteine (PDGFB)

Bezeichnung:
Platelet-Derived Growth Factor beta Polypeptide Proteine (PDGFB)
Auf www.antikoerper-online.de finden Sie aktuell 42 Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PDGFB Antikörper (90) und PDGFB Kits (62) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 201 PDGFB Produkte verfügbar.
Synonyme:
c-sis, PDGF-2, PDGF-B, PDGF2, SIS, SSV
alle Proteine anzeigen Gen GeneID UniProt
PDGFB 18591 P31240
PDGFB 5155 P01127
PDGFB 24628 Q05028

Weitere Synonyme anzeigen

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Am meisten referenzierte PDGFB Proteine

  1. Human PDGFB Protein expressed in HEK-293 Cells - ABIN2181626 : Chen, Cai, Zhang, Liu, Liu: Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. in Experimental and therapeutic medicine 2014 (PubMed)
    Zeige alle 2 Referenzen für 2181626

Weitere Proteine zu PDGFB Interaktionspartnern

Mouse (Murine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Interaktionspartner

  1. PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.

  2. data suggest that the stronger fibrotic effect generated by Pdgfa (zeige PDGFA Proteine) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells

  3. loss-of-function mutations in PDGFB or PDGFRB (zeige PDGFRB Proteine) cause Primary Familial Brain Calcification.

  4. Results suggest that regional Pax3 (zeige PAX3 Proteine) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis

  5. High PDGFB expression is associated with liver fibrosis.

  6. Increased expression of STAT5b (zeige STAT5B Proteine) + PDGFB led to increased expression of downstream STAT5b (zeige STAT5B Proteine) targets.

  7. Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (zeige ABCB4 Proteine)-null mice.

  8. The endogenous levels of PDGF (zeige PDGFA Proteine)-BB, increases CD31 (zeige PECAM1 Proteine)(hi)endomucin (zeige EMCN Proteine)(hi) vessel number and stimulates bone formation in ovariectomy mice.

  9. These findings thus implicate a novel role of PDGF (zeige PDGFA Proteine)-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier

  10. The data indicate a dual role of Lhx2 (zeige LHX2 Proteine) during EMT (zeige ITK Proteine) and tumor progression: by inducing the expression of PDGF-B, Lhx2 (zeige LHX2 Proteine) provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination

Human Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Interaktionspartner

  1. Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma (zeige MOK Proteine).

  2. Insulin (zeige INS Proteine) treatment caused sustained Akt (zeige AKT1 Proteine) activity, whereas EGF (zeige EGF Proteine) or PDGF (zeige PDGFA Proteine)-AA promoted transient signaling; PDGF (zeige PDGFA Proteine)-BB produced sustained responses at higher concentrations.Transient responses to EGF (zeige EGF Proteine) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (zeige IGF1 Proteine) caused full Akt (zeige AKT1 Proteine) activation

  3. high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.

  4. High PDGFB expression is associated with glioma.

  5. A cell-autonomous positive-signaling circuit is associated with the PDGF (zeige PDGFA Proteine)-NO-ID4 (zeige ID4 Proteine)-regulatory axis in glioblastoma cells.

  6. SphK1 (zeige SPHK1 Proteine) is regulated by PDGF (zeige PDGFA Proteine)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (zeige EGR1 Proteine), promoting cell proliferation.

  7. PDGF (zeige PDGFA Proteine)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.

  8. Low concentration of PDGF (zeige PDGFA Proteine)-AB showed synergism with IFN-alpha (zeige IFNA Proteine) in IFN-beta (zeige IFNB1 Proteine) and -gamma induction.

  9. There are four platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) genes (PDGFA (zeige PDGFA Proteine), PDGFB, PDGFC (zeige PDGFC Proteine) and PDGFD (zeige PDGFD Proteine)) that reside on chromosomes 7, 22, 4 and 11.

  10. this study shows that the expression of PDGFB is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts

Cow (Bovine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Interaktionspartner

  1. Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (zeige AKT1 Proteine)/Stat3 (zeige STAT3 Proteine) signaling pathway.

  2. PDGF-B transcription is increased by Nuclear Factor Kappa B

  3. up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (zeige AGT Proteine)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation

  4. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  5. Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.

PDGFB Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • platelet derived growth factor, B polypeptide (Pdgfb)
  • platelet-derived growth factor beta polypeptide (Pdgfb)
  • c-sis Protein
  • PDGF-2 Protein
  • PDGF-B Protein
  • PDGF2 Protein
  • SIS Protein
  • SSV Protein

Bezeichner auf Proteinebene für PDGFB

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , PDGF subunit B , PDGF-2 , c-sis , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide , platelet-derived growth factor subunit B , proto-oncogene c-Sis , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor, beta polypeptide (oncogene SIS) , Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis) , pdgf protein , platelet derived growth factor, B polypeptide , platelet-derived growth factor B , v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog) , platelet-derived growth factor B subunit

GENE ID SPEZIES
100228287 Taeniopygia guttata
18591 Mus musculus
5155 Homo sapiens
24628 Rattus norvegicus
100126843 Sus scrofa
442986 Canis lupus familiaris
540106 Bos taurus
100731469 Cavia porcellus
374128 Gallus gallus
443545 Ovis aries
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