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The present study was aimed at evaluating the hypothesis that nuclear IGF1R localization is not restricted to cancer cells and might constitute a novel physiologically relevant regulatory mechanism. Our data shows that nuclear translocation takes place in a wide array of cells, including normal diploid fibroblasts.
MicroRNA-302b-3p suppresses cell proliferation through AKT (zeige AKT1 Proteine) pathway by targeting IGF-1R in human gastric cancer.
This study reveals contrasting abilities of IGF-1R to interact with each b-arrestin (zeige SAG Proteine) isoform, depending on the presence of the ligand and demonstrates the antagonism between the two b-arrestin (zeige SAG Proteine) isoforms in controlling IGF-1R expression and function, which could be developed into a practical anti-IGF-1R strategy for cancer therapy.
Our results indicated that miR (zeige MLXIP Proteine)-100 could exert tumor suppression function by inhibiting PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and MAPK/ERK (zeige MAPK1 Proteine) signaling pathways via targeting IGFIR
miR (zeige MLXIP Proteine)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
Results provide a mechanistic understanding for the observation that loss of IGF-1R expression decreases tamoxifen sensitivity resulting from reduced FoxO1 (zeige FOXO1 Proteine) expression in breast cancer cells.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
Results provide evidence that uPA (zeige PRAP1 Proteine) and IGF1R directly interact with uPAR (zeige PLAUR Proteine) enhancing malignant potential of triple-negative breast cancer.
High IGF1R expression is associated with skin melanoma.
This study explores the prognostic effect of MET, MET gene copy number, polysomy of chromosome 7, IGF1R gene copy number and IGF-1 (zeige IGF1 Proteine) expression in tumor epithelial cells of primary non-small-cell lung cancer in 326 patients.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (zeige PAPPA Proteine) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (zeige SNRPB Proteine)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (zeige PAPPA Proteine) secretion as a modulator of IGF1 (zeige IGF1 Proteine) in cattle with COD (zeige SNRPB Proteine)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (zeige INS Proteine)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 Proteine), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (zeige IGF1 Proteine) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (zeige FRAP1 Proteine) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (zeige IGF1 Proteine) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (zeige IGF1 Proteine), IGF-II, and IGFBP-3 (zeige IGFBP3 Proteine) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (zeige IL1B Proteine) impaired the actions of IGF-I (zeige IGF1 Proteine) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (zeige SST Proteine)-containing islet D-cells
This study suggests an association between the affinity of insulin (zeige INS Proteine) receptors and number of IGF-1 (zeige IGF1 Proteine) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
Data (including data from studies using heterozygous transgenic mice) suggest that gene expression in liver is altered in a model of inflammation of liver due to partial deficiency of Igf1 (zeige IGF1 Proteine); this leads to over-expression of Igf1 (zeige IGF1 Proteine) receptor, inflammation mediators, and acute-phase proteins, but under-expression of cytoskeletal proteins, extracellular matrix proteins, and tight junction proteins.
Findings indicate that the energy-sensing LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine) pathway regulates IGF1 (zeige IGF1 Proteine) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R-PKB (zeige AKT2 Proteine) pathway.
IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.
Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (zeige INS Proteine) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.
the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (zeige FOXO3 Proteine)-regulated, autophagy-mediated protein degradation
SUMOylation of IGF1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators to increase cell cycle progression and proliferation.
findings demonstrated that significant resistance of the brain to amyloid-beta can be achieved lifelong by suppressing neuronal IGF1R.
Results found that glioblastoma tumors resistant to PDGFR (zeige PDGFRB Proteine) inhibition required the expression and activation of the insulin receptor (IR (zeige INSR Proteine))/insulin (zeige INS Proteine) growth-like factor receptor (IGF1R) for tumor cell proliferation and survival.
Conditional deletion of synaptotagmin-10, the Ca(2 (zeige CA2 Proteine)+) sensor for IGF1 (zeige IGF1 Proteine) secretion from mitral cells, or deletion of IGF1 (zeige IGF1 Proteine) receptor in the olfactory bulb prevented the socially relevant GABAergic long-term potentiation and impaired memory formation after social transmission of food preference.
This study evaluated the expression of IGF-1 (zeige IGF1 Proteine) receptor, insulin receptor (zeige INSR Proteine) AND IGF-1 (zeige IGF1 Proteine) in the lammelar tissue of horses with insulin (zeige INS Proteine)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (zeige INSR Proteine) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (zeige IGF1 Proteine)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit