IGF1R Proteine (IGF1R)

Bezeichnung:
Insulin-Like Growth Factor 1 Receptor Proteine (IGF1R)
Auf www.antikoerper-online.de finden Sie aktuell 42 Insulin-Like Growth Factor 1 Receptor (IGF1R) Proteine von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen IGF1R Antikörper (487) und IGF1R Kits (53) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 598 IGF1R Produkte verfügbar.
Synonyme:
A330103N21Rik, CD221, D930020L01, DKFZp469I0618, hyft, igf-1r, igf-ir, IGF1R, IGFIR, IGFIRC, IGFR, IGFR1, JTK13, xIGF-1R, xigf1r, xIGFR
alle Proteine anzeigen Gen GeneID UniProt
IGF1R 3480 P08069
IGF1R 25718 P24062
IGF1R 16001 Q60751

Weitere Synonyme anzeigen

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Am meisten referenzierte IGF1R Proteine

  1. Human IGF1R Protein expressed in Human Cells - ABIN2002215 : Tollefsen, Stoszek, Thompson: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. in Biochemistry 1991 (PubMed)
    Zeige alle 5 Referenzen für 2002215

Weitere Proteine zu IGF1R Interaktionspartnern

Horse (Equine) Insulin-Like Growth Factor 1 Receptor (IGF1R) Interaktionspartner

  1. This study evaluated the expression of IGF-1 (zeige IGF1 Proteine) receptor, insulin receptor (zeige INSR Proteine) AND IGF-1 (zeige IGF1 Proteine) in the lammelar tissue of horses with insulin (zeige INS Proteine)-induced hyperinsulinemia.

  2. The laminar cell types expressing insulin receptor (zeige INSR Proteine) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

  3. Somatomedin (IGF-I (zeige IGF1 Proteine)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]

Human Insulin-Like Growth Factor 1 Receptor (IGF1R) Interaktionspartner

  1. Results provide evidence that cathepsin G (zeige CTSG Proteine) (GC) activates IGF-1R by stimulating IGF-1 (zeige IGF1 Proteine) release from MCF-7 cells, and that IGF-1R activation is required for CG-induced cell aggregation.

  2. GRK2 (zeige ADRBK1 Proteine) is negatively related to IGF1R and IGF1R, but not GRK2 (zeige ADRBK1 Proteine), was associated with the tumour-node-metastasis stage and overall and disease-free survival in hepatocellular carcinoma.

  3. Heterodimerization of EGFR (zeige EGFR Proteine) with IGF-1R can lead to increased activity of EGFR (zeige EGFR Proteine) and may be an important platform for cetuximab mediated signaling in head and neck tumors that have become resistant to anti-EGFR (zeige EGFR Proteine) therapy.

  4. mTORC1/2 inhibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of IGFR/IR-dependent PI3K (zeige PIK3CA Proteine) activation, and Akt (zeige AKT1 Proteine) phosphorylation via an integrin/FAK (zeige PTK2 Proteine)/IGF1R-dependent process, mediating tumor drug resistance.

  5. We found that the thyroid hormone receptor (zeige THRA Proteine) (TRalpha (zeige THRA Proteine) 3) has a differential expression profile. Thyroid hormone (zeige PTH Proteine) is critical for normal brain development. Our results showed that there is a possible link between IGF1 (zeige IGF1 Proteine)/IGF1R and the TRalpha (zeige THRA Proteine) 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.

  6. Data show that the let-7c/miR (zeige MLXIP Proteine)-99a/miR (zeige MLXIP Proteine)-125b cluster controlled tumorigenesis by targeting IL-6 (zeige IL6 Proteine), IL-6R and IGF1R.

  7. IGF1R expression may have prognostic relevance in penile squamous cell carcinoma

  8. High IGF1R expression is associated with bone metastasis in prostate cancer.

  9. the Runx2 (zeige RUNX2 Proteine) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (zeige GRK4 Proteine)), the sensor of cellular metabolism. Importantly, the Runx2 (zeige RUNX2 Proteine) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 inhibition and AMPKalpha (zeige GRK4 Proteine) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (zeige GRK4 Proteine) levels.

  10. Overexpression of mutated K-RAS in gastrointestinal cancer cell lines led to more aggressive phenotypes, with increased proliferation, decreased apoptosis, and increased motility and invasion. IGF-1R blockade suppressed cell growth, colony formation, migration, and invasion, and up-regulated chemotherapy-induced apoptosis of gastrointestinal cancer cells, even when mutated K-RAS was over-expressed.

Pig (Porcine) Insulin-Like Growth Factor 1 Receptor (IGF1R) Interaktionspartner

  1. IGF-I (zeige IGF1 Proteine), IGF-II, and IGFBP-3 (zeige IGFBP3 Proteine) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

  2. IL-1beta (zeige IL1B Proteine) impaired the actions of IGF-I (zeige IGF1 Proteine) at a point distal to the IGF receptor

  3. IGF-1R is expressed in porcine somatostatin (zeige SST Proteine)-containing islet D-cells

  4. This study suggests an association between the affinity of insulin (zeige INS Proteine) receptors and number of IGF-1 (zeige IGF1 Proteine) receptors with placental and/or fetal growth.

  5. mRNA expression of IGF-I receptor

Cow (Bovine) Insulin-Like Growth Factor 1 Receptor (IGF1R) Interaktionspartner

  1. A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.

  2. study determined IGFR1 and PAPP-A (zeige PAPPA Proteine) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (zeige SNRPB Proteine)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (zeige PAPPA Proteine) secretion as a modulator of IGF1 (zeige IGF1 Proteine) in cattle with COD (zeige SNRPB Proteine)

  3. Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.

  4. two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle

  5. insulin (zeige INS Proteine)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization

  6. The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.

  7. Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 Proteine), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  8. Results do not support the premise that increased apoptosis associated with high levels of IGF1 (zeige IGF1 Proteine) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.

  9. IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (zeige FRAP1 Proteine) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.

  10. IGF-1 (zeige IGF1 Proteine) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.

Mouse (Murine) Insulin-Like Growth Factor 1 Receptor (IGF1R) Interaktionspartner

  1. IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.

  2. Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (zeige INS Proteine) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.

  3. the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (zeige FOXO3 Proteine)-regulated, autophagy-mediated protein degradation

  4. SUMOylation of IGF1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators to increase cell cycle progression and proliferation.

  5. findings demonstrated that significant resistance of the brain to amyloid-beta can be achieved lifelong by suppressing neuronal IGF1R.

  6. Results found that glioblastoma tumors resistant to PDGFR (zeige PDGFRB Proteine) inhibition required the expression and activation of the insulin receptor (IR (zeige INSR Proteine))/insulin (zeige INS Proteine) growth-like factor receptor (IGF1R) for tumor cell proliferation and survival.

  7. Conditional deletion of synaptotagmin-10, the Ca(2 (zeige CA2 Proteine)+) sensor for IGF1 (zeige IGF1 Proteine) secretion from mitral cells, or deletion of IGF1 (zeige IGF1 Proteine) receptor in the olfactory bulb prevented the socially relevant GABAergic long-term potentiation and impaired memory formation after social transmission of food preference.

  8. These results support the role of Igf1r in controlling the kinetics of cell proliferation and differentiation during pulmonary airway epithelial regeneration after injury.

  9. Although smaller than WT (wild type) mice, old-aged Igf1r(+/-) had increased adiposity and exhibit increased lipogenesis. We hypothesize that IGF-1 (zeige IGF1 Proteine) resistance initially causes a transient increase in insulin (zeige INS Proteine) signaling thereby promoting a lipogenic phenotype, which subsequently leads to insulin (zeige INS Proteine) resistance.

  10. HASF is a novel ligand of IGF1R.

IGF1R Protein Überblick

Protein Überblick

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Alternative names and synonyms associated with IGF1R

  • insulin-like growth factor 1 receptor (IGF1R)
  • insulin-like growth factor 1 receptor (Igf1r)
  • insulin-like growth factor 1 receptor (igf1r)
  • insulin-like growth factor I receptor (Igf1r)
  • insulin-like growth factor I receptor (LOC780503)
  • insulin-like growth factor I receptor (igf-ir)
  • A330103N21Rik Protein
  • CD221 Protein
  • D930020L01 Protein
  • DKFZp469I0618 Protein
  • hyft Protein
  • igf-1r Protein
  • igf-ir Protein
  • IGF1R Protein
  • IGFIR Protein
  • IGFIRC Protein
  • IGFR Protein
  • IGFR1 Protein
  • JTK13 Protein
  • xIGF-1R Protein
  • xigf1r Protein
  • xIGFR Protein

Bezeichner auf Proteinebene für IGF1R

IGF-I receptor , insulin-like growth factor I receptor , soluble IGF1R variant 1 , soluble IGF1R variant 2 , insulin-like growth factor receptor tyrosine kinase , insulin-like growth factor-I receptor , type 1 IGF receptor , tyrosine kinase , IGF-1 receptor , insulin-like growth factor 1 receptor beta subunit , insulin-like growth factor receptor 1 , insulin-like growth factor-1 receptor , receptor tyrosine kinase , insulin-like growth factor 1 receptor , line 186 , insulin-like growth factor-1 receptor beta subunit , xIGF-1R , xIGFR

GENE ID SPEZIES
3480 Homo sapiens
25718 Rattus norvegicus
281848 Bos taurus
395889 Gallus gallus
397350 Sus scrofa
442951 Canis lupus familiaris
453676 Pan troglodytes
100172156 Pongo abelii
100329112 Xenopus (Silurana) tropicalis
16001 Mus musculus
100020095 Monodelphis domestica
780503 Ovis aries
100136427 Salmo salar
398022 Xenopus laevis
100055698 Equus caballus
100734840 Cavia porcellus
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