FIGF Proteine (Figf)

Auf finden Sie aktuell 36 C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FIGF Antikörper (167) und FIGF Kits (55) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 268 FIGF Produkte verfügbar.
AI325264, FIGF, Vegf-d, Vegfd
alle Proteine anzeigen Gen GeneID UniProt
Figf 14205 P97946
Figf 360457 O35251
Figf 2277 O43915

FIGF Proteine (Figf) nach Spezies

Weitere Proteine zu FIGF Interaktionspartnern

Zebrafish C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Interaktionspartner

  1. vegfc (zeige VEGFC Proteine) and vegfd cooperatively control lymphangiogenesis throughout the embryo, including during the formation of the trunk lymphatic vasculature. Interestingly, we find that vegfd and vegfc (zeige VEGFC Proteine) also redundantly drive artery hyperbranching phenotypes observed upon depletion of Flt1 (zeige FLT1 Proteine) or Dll4 (zeige DLL4 Proteine).

  2. Vegfd can compensate for loss of Vegfc (zeige VEGFC Proteine) in zebrafish facial lymphatic sprouting.

  3. VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.

  4. Our studies therefore identified the first non-mammalian VEGF-D and established its in vivo role for vascular system development during vertebrate embryogenesis and provided an alternative animal model to further reveal functions of VEGF-D.

Mouse (Murine) C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Interaktionspartner

  1. lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC (zeige VEGFC Proteine) activation by ADAMTS3 (zeige Adamts2 Proteine) and CCBE1 (zeige CCBE1 Proteine) spatially and temporally patterns developing lymphatics, and one in which VEGFD activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth

  2. This study uncovers a reciprocal relationship between dendrite geometry, the ability to generate nuclear calcium transients in response to synaptic inputs, and the subsequent induction of expression of plasticity-related and dendritic structure-preserving genes. Insufficient nuclear calcium signaling in CA1 (zeige CA1 Proteine) hippocampal neurons and, consequently, reduced expression of the nuclear calcium target gene VEGFD.

  3. Overexpression of VEGFD causes lymphatic hyperplasia in lung, kidney, and brown adipose tissue. Overexpression of VEGFD in white adipose tissue causes a de novo lymphatic network.

  4. Vegf-d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF-D signalling promotes vascular leak in human hyperoxic acute lung injury (HALI).

  5. VEGF-D may be beneficial in early-stage tumors since it suppresses the pro-tumorigenic inflammation, while at later stages VEGF-D-induced tumor lymphatics provide a route for metastasis.

  6. These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A (zeige VEGFA Proteine) and VEGF-D play critical roles in this process.

  7. Results provided evidence that IL-7 (zeige IL7 Proteine)/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun (zeige JUN Proteine) pathway in lung cancer.

  8. Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C (zeige VEGFC Proteine) or VEGF-D.

  9. Neutrophils contribute to lymphangiogenesis primarily by modulating VEGF-A (zeige VEGFA Proteine) bioavailability and bioactivity and, to a lesser extent, secreting VEGF-D. Neutrophils increased VEGF-A (zeige VEGFA Proteine) bioavailability and bioactivity via the secretion of MMP9 (zeige MMP9 Proteine) and heparanase (zeige HPSE Proteine).

  10. Vegf-d deficiency alters the caliber of initial lymphatics in the dermis leading to reduced functional capacity.

Human C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Interaktionspartner

  1. High VEGFD expression is associated with lymphangioleiomyomatosis.

  2. Data show that VEGF-C (zeige VEGFC Proteine), VEGF-D, and VEGFR-3 (zeige FLT4 Proteine) were expressed in a substantial percentage of breast carcinomas.

  3. High VEGFD expression is associated with angiogenesis and lymphangiogenesis.

  4. VEGF-D and its receptors were co-localized on blood vessels in clinical samples of human lungs exposed to hyperoxia; hence, VEGF-D may act directly on blood vessels to promote fluid leak.

  5. VEGF-D-enhanced metastasis was evidently reversed by MP. MP significantly reduced the invasion of VEGFD-SK cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups

  6. Sulf2 (zeige SULF2 Proteine) facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved.

  7. Data indicate that vascular endothelial growth factor D (VEGF-D) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3 (zeige FLT4 Proteine)) may help to determine the prognosis and management of colorectal cancer (CRC (zeige CALR Proteine)).

  8. Taken together, our data suggest that TNF-alpha (zeige TNF Proteine) can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1 (zeige FOSB Proteine)/VEGF-D pathway.

  9. VEGF-D may play an important role in the process of lymphatic metastasis of epithelial ovarian cancer

  10. CCL21 (zeige CCL21 Proteine)/CCR7 (zeige CCR7 Proteine) induce VEGF-D up-regulation and promote lymphangiogenesis via ERK (zeige EPHB2 Proteine)/Akt (zeige AKT1 Proteine) pathway in lung cancer.

FIGF (Figf) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.

Alternative names and synonyms associated with FIGF (Figf)

  • c-fos induced growth factor (vascular endothelial growth factor D) (FIGF)
  • c-fos induced growth factor (figf)
  • c-fos induced growth factor (vascular endothelial growth factor D) (figf)
  • Vascular endothelial growth factor D (vegfd)
  • c-fos induced growth factor (Figf)
  • AI325264 Protein
  • FIGF Protein
  • Vegf-d Protein
  • Vegfd Protein

Bezeichner auf Proteinebene für Figf

c-fos induced growth factor (vascular endothelial growth factor D) , vascular endothelial growth factor D , vascular enthelial growth factor D , vegf d , vegf-d , Vascular endothelial growth factor D , c-fos-induced growth factor

712654 Macaca mulatta
100050877 Equus caballus
100601827 Nomascus leucogenys
678512 Danio rerio
100144690 Xenopus (Silurana) tropicalis
100158352 Xenopus laevis
465508 Pan troglodytes
493703 Felis catus
100195607 Salmo salar
14205 Mus musculus
360457 Rattus norvegicus
2277 Homo sapiens
286799 Bos taurus
100338090 Oryctolagus cuniculus
100155670 Sus scrofa
491749 Canis lupus familiaris
395255 Gallus gallus
101102873 Ovis aries
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