EPH Receptor B4 Proteine (EPHB4)

Bezeichnung:
EPH Receptor B4 Proteine (EPHB4)
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Synonyme:
AI042935, ephB4a, ephb4b, HTK, MDK2, MGC130997, MYK1, TYRO11
alle Proteine anzeigen Gen GeneID UniProt
EPHB4 13846 P54761
EPHB4 2050 P54760
Ratte EPHB4 EPHB4 686310  

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EPH Receptor B4 Proteine (EPHB4) nach Spezies

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Am meisten referenzierte EPH Receptor B4 Proteine

  1. Human EPH Receptor B4 Protein expressed in Human Cells - ABIN2002400 : Bennett, Wang, Kuang, Wang, Groopman, Goeddel, Scadden: Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. in The Journal of biological chemistry 1994 (PubMed)
    Zeige alle 5 Referenzen für 2002400

  2. Human EPH Receptor B4 Protein expressed in Baculovirus infected Insect Cells - ABIN2002404 : Noren, Lu, Freeman, Koolpe, Pasquale: Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Zeige alle 5 Referenzen für 2002404

  3. Mouse (Murine) EPH Receptor B4 Protein expressed in Human Cells - ABIN2008001 : Murai, Pasquale: 'Eph'ective signaling: forward, reverse and crosstalk. in Journal of cell science 2003 (PubMed)
    Zeige alle 5 Referenzen für 2008001

  4. Human EPH Receptor B4 Protein expressed in HEK-293 Cells - ABIN2181023 : Kertesz, Krasnoperov, Reddy, Leshanski, Kumar, Zozulya, Gill: The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. in Blood 2006 (PubMed)
    Zeige alle 4 Referenzen für 2181023

Weitere Proteine zu EPH Receptor B4 Interaktionspartnern

Mouse (Murine) EPH Receptor B4 (EPHB4) Interaktionspartner

  1. EPHB4 is a critical regulator of early lymphatic vascular development; mutations in the gene can cause an autosomal dominant form of LRHF that is associated with a high mortality rate

  2. These results identify EPHB4/ephrin B2 (zeige EFNB2 Proteine) signaling as critical to Hematopoietic stem and progenitor cells mobilization from bone marrow

  3. EphB4 plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 (zeige EFNB2 Proteine) can be effectively compensated, most possibly by other ephrins with similar chemical structures

  4. Eph (zeige EPHA1 Proteine)-B4 stimulates eNOS (zeige NOS3 Proteine) phosphorylation in vitro and may mediate vein graft adaptation by regulation of eNOS (zeige NOS3 Proteine) activity in vivo.

  5. These data indicate that ephrinB2 (zeige EFNB2 Proteine)/EphB4 signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.

  6. EphB4 promotes endochondral ossification while inhibiting osteoclast development during callus formation.

  7. Selective inhibition of EphB4 using a functional blocking antibody results in defective lymphatic valve development.

  8. Overexpression of bone-specific Ephb4 clearly demonstrated prevention of the development and/or progression of fibrosis in OA synovial membrane

  9. EphB4-forward signaling plays a crucial role in the development of cardiac progenitor cells.

  10. EPHB4 plays an essential role in regulating small artery contractility and blood pressure

Human EPH Receptor B4 (EPHB4) Interaktionspartner

  1. EPHB4 mutations were identified in patients with multifocal capillary malformation with arteriovenous malformations.

  2. EPHB4 is a critical regulator of early lymphatic vascular development; mutations in the gene can cause an autosomal dominant form of lymphatic-related hydrops fetalis that is associated with a high mortality rate

  3. The expression of EPHB4 was increased in gastric cancer and increased EPHB4 expression was correlated with poor survival. Knockdown of EPHB4 promoted adhesion and exerted diverse effects on migration of gastric cancer cells.

  4. EphB4 protein acts as a tumour promoter associated with proliferation, invasion, and angiogenesis, and may be used as a potential colorectal cancer (CRC (zeige CALR Proteine)) therapeutic target.

  5. Study illustrates that aberrant activation of EphB4/ephrinB2 (zeige EFNB2 Proteine) may mediate chronic myeloid leukemia (zeige BCL11A Proteine) resistance involved in cytoskeletal proteins.

  6. both EphA2 (zeige EPHA2 Proteine) and EphB4 show potential as target for image-guided colorectal cancer surgery, but EphB4 seems to have the best characteristics with respect to tumor/normal mucosa distribution.

  7. Survival analysis showed that the non-small cell lung carcinoma patients with enhanced expression of CK7 (zeige KRT7 Proteine), ELF3 (zeige ELF3 Proteine), EGFR (zeige EGFR Proteine), and EphB4 mRNA in peripheral blood leukocytes had poorer disease-free survival and overall survival than those without.

  8. Enhanced EphB4 expression was significantly associated with Thyroid Lesions.

  9. LISA method may be considered rapid and sensitive enough to detect even low levels of total and phosphorylated EphB4 Cost-effectiveness of this method for the detection of differential expression of EphB4 proteins in clinics is also noticeable.

  10. EphB4 facilitates stromal-mediated support of hematopoiesis in hematopoietic stem cells.

EPH Receptor B4 (EPHB4) Protein Überblick

Protein Überblick

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

Alternative names and synonyms associated with EPH Receptor B4 (EPHB4)

  • EPH receptor B4 (EPHB4)
  • EPH receptor B4 (ephb4-a)
  • EPH receptor B4 (ephb4)
  • EPH receptor B4 (LOC100359286)
  • Eph receptor B4 (Ephb4)
  • EPH receptor B4 (Ephb4)
  • AI042935 Protein
  • ephB4a Protein
  • ephb4b Protein
  • HTK Protein
  • MDK2 Protein
  • MGC130997 Protein
  • MYK1 Protein
  • TYRO11 Protein

Bezeichner auf Proteinebene für EPH Receptor B4 Proteine (EPHB4)

EPH receptor B4 , eph receptor tyrosine kinase , ephrin receptor EphB4 , ephrin type-B receptor 4-like , developmental kinase 2 , ephrin type-B receptor 4 , hepatoma transmembrane kinase , mDK-2 , tyrosine kinase MYK-1 , soluble EPHB4 variant 1 , soluble EPHB4 variant 2 , soluble EPHB4 variant 3 , tyrosine-protein kinase TYRO11 , tyrosine-protein kinase receptor HTK

GENE ID SPEZIES
100069098 Equus caballus
398362 Xenopus laevis
463610 Pan troglodytes
100191023 Xenopus laevis
100359286 Oryctolagus cuniculus
100461743 Pongo abelii
100483535 Ailuropoda melanoleuca
100497297 Xenopus (Silurana) tropicalis
100563254 Anolis carolinensis
100591047 Nomascus leucogenys
13846 Mus musculus
2050 Homo sapiens
489830 Canis lupus familiaris
100517028 Sus scrofa
515756 Bos taurus
686310 Rattus norvegicus
100735745 Cavia porcellus
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