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In a model of temporal lobe epilepsy, Ephrin-A4 and Ephrin-A5 (zeige EFNA5 Proteine) increase in the hippocampus in a spatiotemporal course.
ephrin-A4 plays an important role in retinal NV and is a potential target against retinal NV. The proangiogenic function of ephrin-A4 may be linked to its crucial role in the VEGF signaling pathway.
Downregulation of the EphA4 (zeige EPHA4 Proteine) receptor via siRNA transfection reduced the repulsive effect of ephrin-A3 (zeige EFNA3 Proteine), indicating that EphA4 (zeige EPHA4 Proteine) mediates at least in part the repulsive effect of ephrin-A3 (zeige EFNA3 Proteine).
LIM homeodomain proteins control axon pathways topographic projections in the limb through control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells.
Ephrin A4 receptor in the thalamus and ephrin A4 in the cerebral cortex control intra-areal topographic mapping of thalamocortical axons.
The present study provides evidence that microglia upregulates endothelial ephrin-A3 (zeige EFNA3 Proteine) and ephrin-A4 to facilitate in vitro angiogenesis of brain endothelial cells, which is mediated by microglia-released TNF-alpha (zeige TNF Proteine).
The interaction between ephrin-As, Eph (zeige EPHA1 Proteine) receptors and integrin alpha3 is plausibly important for the crosstalk between Eph (zeige EPHA1 Proteine) and integrin signalling pathways at the membrane protrusions and in the migration of brain cancer cells.
The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy.
This provides genetic evidence that Twist1 (zeige TWIST1 Proteine), Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis.
CLL B-cells showed a more heterogeneous Eph (zeige EPHA1 Proteine)/EFN profile, specially EFNA4, EphB6 (zeige EPHB6 Proteine) and EphA10 (zeige EPHA10 Proteine). EphB6 (zeige EPHB6 Proteine) and EFNA4 were further related with the clinical course of CLL.
EFNA4-EphA2 (zeige EPHA2 Proteine) interactions are involved in Chronic lymphocytic leukemia cell trafficking between blood and the tissues
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.
, EPH-related receptor tyrosine kinase ligand 4
, eph-related receptor tyrosine kinase ligand 4
, ligand of eph-related kinase 4