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Human Calmodulin 2 Protein expressed in Wheat germ - ABIN1347887
Lin, Hsieh, Lin, Fang, Yang, Tsai, Chiang, Pan, Chen: Label-free detection of protein-protein interactions using a calmodulin-modified nanowire transistor. in Proceedings of the National Academy of Sciences of the United States of America 2010
Impaired Ca(2+)-dependent inactivation in human cardiomyocytes as the plausible mechanism for Long QT Syndrome associated with 2 novel CaM mutations.
Authors successfully recapitulated the disease phenotypes of LQT15 and revealed that inactivation of LTCC currents was impaired in CALM2-N98S hiPSC model.
the spectrum and prevalence of pathogenic CaM variants in a cohort of genetically elusive long QT syndrome, were determined.
Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders.
5 novel de novo CALM2 mutations in association with long-QT syndrome and exertioninduced arrhythmias.(p.N98S, p.N98I, p.D134H, p.D132E, p.Q136P)
CaM-2-ext interacts biochemically with the C-terminus of Ca(v)2.3 similar to the classical CaM-2 as shown by co-immunoprecipitation
Human calmodulin mutations disrupt calcium binding to the protein and are associated with cardiac arrest in early infancy.
The 1.35 A structure of Ca(2+)-bound calmodulin in complex with the DIII-IV linker of Na(V)1.5 suggests that Ca(2+)/CaM destabilizes binding of the inactivation gate to its receptor, biasing inactivation toward more depolarized potentials.
These findings suggest that the CALM2 gene may be a genetic determinant of hip Osteoarthritis.
P53 protein stimulates CAMII gene expression in 041 cells.
Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 (zeige CACNA1C Proteine) L-type Ca2 (zeige CA2 Proteine)+ channels by calmodulin and Ca2 (zeige CA2 Proteine)+-binding protein 1.
CaM binds two molecules of ER-alpha (zeige ESR1 Proteine) in a 1:2 complex and stabilizes ER-alpha (zeige ESR1 Proteine) dimerization.
Calmodulin is well known to modulate many cytoplasmic reactions; thus, its passage through gap junctions opens possibilities of additional means by which cells may be supplied with this signaling molecule, and by which their supply may be regulated.
These results provide genetic evidence of the involvement of a CAM gene in pollen germination and support the theory of functional diversification of the CAM gene family.
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
, phosphorylase kinase delta
, prepro-calmodulin 2
, calmodulin 2 (phosphorylase kinase, delta)