Uridine Monophosphate Synthetase Proteine (UMPS)

Uridine Monophosphate Synthetase Proteine (UMPS)
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1700095D23Rik, AA408257, AL033308, BB164745, OPRT, UMPS, zgc:55702, zgc:55723
alle Proteine anzeigen Gen GeneID UniProt
UMPS 7372 P11172
UMPS 22247 P13439
Ratte UMPS UMPS 288051  

Weitere Synonyme anzeigen

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Am meisten referenzierte Uridine Monophosphate Synthetase Proteine

  1. Human UMPS Protein expressed in Escherichia coli (E. coli) - ABIN1098695 : Suchi, Mizuno, Kawai, Tsuboi, Sumi, Okajima, Hodgson, Ogawa, Wada: Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. in American journal of human genetics 1997 (PubMed)
    Zeige alle 2 Referenzen für 1098695

  2. Human UMPS Protein expressed in HEK-293 Cells - ABIN2735007 : Bardeleben, Sharma, Reeve, Bassilian, Frost, Hoang, Shi, Lichtenstein: Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells. in Molecular cancer therapeutics 2013 (PubMed)

Weitere Proteine zu Uridine Monophosphate Synthetase Interaktionspartnern

Caenorhabditis elegans (C. elegans) Uridine Monophosphate Synthetase (UMPS) Interaktionspartner

  1. the conserved uridine monophosphate phosphoribosyltransferase (UMPS), which acts in pyrimidine biosynthesis, is required for NAD(+) biosynthesis in place of the missing QPRTase (zeige QPRT Proteine)

Human Uridine Monophosphate Synthetase (UMPS) Interaktionspartner

  1. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.

  2. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer

  3. OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes.

  4. The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer

  5. [review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity

  6. OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU.

  7. High expression levels of orotate phosphoribosyl transferase and thymidylate synthase (zeige TYMS Proteine) in colorectal cancer appear to be significantly involved in metastasis after curative surgery

  8. Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS.

  9. orotate phosphoribosyl transferase/DPD (zeige DPYD Proteine) ratio has a relation to cancer staging and survival rate.

  10. Increased orotate phosphoribosyltransferase expression is associated with bladder cancers.

Uridine Monophosphate Synthetase (UMPS) Protein Überblick

Protein Überblick

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with Uridine Monophosphate Synthetase (UMPS)

  • Uridine MonoPhosphate Synthetase (umps-1)
  • uridine monophosphate synthetase (umps)
  • uridine monophosphate synthetase (UMPS)
  • uridine monophosphate synthetase (Umps)
  • 1700095D23Rik Protein
  • AA408257 Protein
  • AL033308 Protein
  • BB164745 Protein
  • OPRT Protein
  • UMPS Protein
  • zgc:55702 Protein
  • zgc:55723 Protein

Bezeichner auf Proteinebene für UMPS

Uridine MonoPhosphate Synthetase family member (umps-1) , uridine 5'-monophosphate synthase , uridine monophosphate synthetase , uridine monophosphate synthase , uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) , OMPdecase , OPRTase , UMP synthase , orotate phosphoribosyltransferase , orotidine 5'-phosphate decarboxylase , orotate phosphoribosyl transferase and orotidine-5'-decarboxylase

176453 Caenorhabditis elegans
393143 Danio rerio
494728 Xenopus laevis
100070386 Equus caballus
100353794 Oryctolagus cuniculus
100556619 Anolis carolinensis
424256 Gallus gallus
460644 Pan troglodytes
496817 Xenopus (Silurana) tropicalis
715664 Macaca mulatta
780512 Ovis aries
7372 Homo sapiens
478593 Canis lupus familiaris
281568 Bos taurus
22247 Mus musculus
288051 Rattus norvegicus
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