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Human UMPS Protein expressed in HEK-293 Cells - ABIN2735007
Bardeleben, Sharma, Reeve, Bassilian, Frost, Hoang, Shi, Lichtenstein: Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells. in Molecular cancer therapeutics 2013
the conserved uridine monophosphate phosphoribosyltransferase (UMPS), which acts in pyrimidine biosynthesis, is required for NAD(+) biosynthesis in place of the missing QPRTase (zeige QPRT Proteine)
Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.
The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer
OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes.
The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer
[review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity
OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU.
High expression levels of orotate phosphoribosyl transferase and thymidylate synthase (zeige TYMS Proteine) in colorectal cancer appear to be significantly involved in metastasis after curative surgery
Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS.
orotate phosphoribosyl transferase/DPD (zeige DPYD Proteine) ratio has a relation to cancer staging and survival rate.
Increased orotate phosphoribosyltransferase expression is associated with bladder cancers.
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
Uridine MonoPhosphate Synthetase family member (umps-1)
, uridine 5'-monophosphate synthase
, uridine monophosphate synthetase
, uridine monophosphate synthase
, uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
, UMP synthase
, orotate phosphoribosyltransferase
, orotidine 5'-phosphate decarboxylase
, orotate phosphoribosyl transferase and orotidine-5'-decarboxylase