PRPS1 Proteine (PRPS1)

Bezeichnung:
phosphoribosyl Pyrophosphate Synthetase 1 Proteine (PRPS1)
Auf www.antikoerper-online.de finden Sie aktuell 20 phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PRPS1 Antikörper (37) und PRPS1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 61 PRPS1 Produkte verfügbar.
Synonyme:
2310010D17Rik, ARTS, C76571, C76678, CMTX5, DFN2, DFNX1, PPRibP, Prps-1, PRS-I, PRSI
alle Proteine anzeigen Gen GeneID UniProt
PRPS1 5631 P60891
PRPS1 19139 Q9D7G0
PRPS1 29562 P60892

Weitere Synonyme anzeigen

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Am meisten referenzierte PRPS1 Proteine

  1. Human PRPS1 Protein expressed in Escherichia coli (E. coli) - ABIN666934 : Li, Lu, Peng, Ding: Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site. in The Biochemical journal 2006 (PubMed)
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Weitere Proteine zu PRPS1 Interaktionspartnern

Human phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Interaktionspartner

  1. High PRPS1 expression is associated with chemoresistance in breast cancer.

  2. evaluation of current literature on PRPS1-related syndromes and summaries of potential therapies [review]

  3. analysis of intrafamilial phenotypic variation associated with a single PRPS1 mutation in syndromic or nonsyndromic hearing impairment

  4. CRC (zeige CALR Proteine) cells that overexpressed miR124 or with knockdown of RPIA (zeige RPIA Proteine) or PRPS1 had reduced DNA synthesis and proliferation, whereas cells incubated with an inhibitor of miR124 had significantly increased DNA synthesis and proliferation and formed more colonies.

  5. Study identified the critical region in the ARTS promoter and demonstrated that the Sp1 transcription factor (zeige SP1 Proteine) could regulate the activity of the ARTS promoter through multiple Sp1 (zeige PSG1 Proteine) binding sites.

  6. Females with a missense mutation in PRPS1, exhibit neuropathy, hearing loss and retinopathy.

  7. the de novo purine synthesis inhibitor lometrexol effectively abrogated PRPS1 mutant-driven drug resistance.

  8. The expression of different genes encoding subunits of PRPS (zeige MSMB Proteine) enzyme is affected by hypoxia in tumor glioma cells, but the effect of hypoxia is modified by suppression of endoplasmic reticulum stress signaling enzyme ERN1 (zeige ERN1 Proteine).

  9. respective phenotypic presentation seems to be determined by the exact PRPS1 mutation and the residual enzyme activity, the latter being largely influenced by the degree of skewed X-inactivation

  10. The crystal structure of the ADP-binding pocket of the PRPS1 D52H-mutant and evidence of reduced inhibitor sensitivity.

Mouse (Murine) phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Interaktionspartner

  1. PRPS1 knockdown prolonged survival time, reduced tumor volume and upregulated apoptosis in xenograft mouse model of glioma.

  2. Only unedited pri-miR (zeige MLXIP Proteine)-376 RNAs were detected in the cochlea suggesting that the activity of PRPS1 in the inner ear may not be regulated through the editing of miR (zeige MLXIP Proteine)-376 cluster.

  3. PRPS1 loss of function mutations cause a type of nonsyndromic X-linked sensorineural deafness, DFN2

PRPS1 Protein Überblick

Protein Überblick

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PRPS1

  • phosphoribosyl pyrophosphate synthetase 1 (PRPS1)
  • phosphoribosyl pyrophosphate synthetase 1 (Prps1)
  • ribose-phosphate pyrophosphokinase I -like (LOC314140)
  • 2310010D17Rik Protein
  • ARTS Protein
  • C76571 Protein
  • C76678 Protein
  • CMTX5 Protein
  • DFN2 Protein
  • DFNX1 Protein
  • PPRibP Protein
  • Prps-1 Protein
  • PRS-I Protein
  • PRSI Protein

Bezeichner auf Proteinebene für PRPS1

dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1) , deafness 2, perceptive, congenital , deafness, X-linked 2, perceptive, congenital , phosphoribosyl pyrophosphate synthase I , ribose-phosphate diphosphokinase 1 , ribose-phosphate pyrophosphokinase 1 , phosphoribosyl pyrophosphate synthetase I , PRS-I

GENE ID SPEZIES
5631 Homo sapiens
19139 Mus musculus
29562 Rattus norvegicus
781227 Bos taurus
314140 Rattus norvegicus
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