PITX2 Proteine (PITX2)

Auf www.antikoerper-online.de finden Sie aktuell 12 Paired-Like Homeodomain 2 (PITX2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PITX2 Antikörper (76) und PITX2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 100 PITX2 Produkte verfügbar.
Synonyme:
9430085M16Rik, ARP1, Brx1, Brx1a, Brx1b, IDG2, IGDS, IGDS2, IHG2, IRID2, Munc30, Otlx2, pitx-2, pitx2, pitx2-A, pitx2a, Pitx2b, Pitx2c, Pitx2cbeta, Ptx2, RGS, Rieg, RIEG1, RS, xpitx2, xPtx2, XPtx2b, zgc:110508
alle Proteine anzeigen Gen GeneID UniProt
PITX2 5308 Q99697
PITX2 54284 Q9R0W1
PITX2 18741 P97474

PITX2 Proteine (PITX2) nach Spezies

Weitere Proteine zu PITX2 Interaktionspartnern

Xenopus laevis Paired-Like Homeodomain 2 (PITX2) Interaktionspartner

  1. ESR1 (zeige ESR1 Proteine) inhibits the expression of Pitx2 gene by binding to a left side-specific enhancer region in Pitx2 gene and recruiting histone deacetylase 1 (zeige HDAC1 Proteine) to this region, leading to the suppression of Pitx2 gene in the left lateral plate mesoderm.

Human Paired-Like Homeodomain 2 (PITX2) Interaktionspartner

  1. Glaucoma prevalence and phenotype are characterized in a cohort of glaucoma patients and their family members with PITX2 variants.

  2. Using an independent analytical platform, PITX2 methylation was validated as a prognostic biomarker in HNSCC patients, identifying patients that potentially benefit from intensified surveillance and/or administration of adjuvant/neodjuvant treatment, i.e. immunotherapy.

  3. Pitx2 promoter region is methylated in atrial fibrillation patients.

  4. Findings suggest ESR1 (zeige ESR1 Proteine) and PITX2 promoter methylation may be correlated with a worse survival of patients with breast cancer. The clinical utility of aberrantly methylated ESR1 (zeige ESR1 Proteine) and PITX2 could be a promising factor for the prognosis of breast cancer.

  5. PITX2 methylation was significantly increased in tumor-positive biopsies and strongly correlated with International Society of Urological Pathology (ISUP) grade groups.

  6. the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a (zeige TFAP2A Proteine); such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF

  7. Study showed that PITX3 (zeige PITX3 Proteine) and PITX2 were hypermethylated in prostate carcinomas (PCa (zeige FLVCR1 Proteine)) and significantly associated with established clinicopathologic parameters characteristic of PCa (zeige FLVCR1 Proteine).

  8. The PITX2 gene expression level in prostate cancer tissues was lower than that in benign tissues. A higher degree of PITX2 DNA methylation (zeige HELLS Proteine) was associated with higher tumor stage and lower survival rates. PITX2 DNA methylation (zeige HELLS Proteine) presents a good predictive value for prostate cancer survival.

  9. This is the first study reporting on bi-allelic changes of PITX2 potentially contributing to a more severe Axenfeld-Rieger syndrome (ARS (zeige SLURP1 Proteine)) phenotype.

  10. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 (zeige BBS5 Proteine) and thus affecting immune functions and intraocular pressure.

Mouse (Murine) Paired-Like Homeodomain 2 (PITX2) Interaktionspartner

  1. Uncovering a Pitx2-Sox2 (zeige SOX2 Proteine)-Lef-1 (zeige LEF1 Proteine) transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.

  2. Study reports that p27 (zeige CDKN1B Proteine) normally exerts a negative feedback on p21 expression: p27 (zeige CDKN1B Proteine) directly represses the expression of the transcription factor Pitx2 which in turn maintains decreased p21 levels. Consequently, in cells lacking p27 (zeige CDKN1B Proteine), de-repression of Pitx2 causes the up-regulation of p21 showing a new mechanism by which p27 (zeige CDKN1B Proteine) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 and p21.

  3. demonstrate a dose-dependent relation between Pitx2 expression and the expression of atrial fibrillation susceptibility genes

  4. Data suggest a putative role of the homeobox protein PITX2 (PITX2B) isoform during ventricular septation as well as in the maturation of the right portion of the atrioventricular canal.

  5. Pitx2 represses left-side expression of a conserved lncRNA Playrr. Pitx2 auto-regulation directs chromatin topology to coordinate left-right transcription and organogenesis.

  6. The AP-2beta (zeige TFAP2B Proteine) transcription factor is an important effector of PITX2 function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.

  7. Pitx2-deficient neonatal mouse hearts failed to repair after apex (zeige APEX1 Proteine) resection, whereas adult mouse cardiomyocytes with Pitx2 gain-of-function efficiently regenerated after myocardial infarction

  8. This study describes a Pitx2-miRNA pathway controlling cell proliferation in myogenic cells, providing new targets to enhance the regenerative capacity of limb skeletal-muscle myogenic precursor cells for the treatment of skeletal-muscle diseases.

  9. de-regulation of both PITX2 and ENPEP (zeige ENPEP Proteine) could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants.

  10. Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine

Zebrafish Paired-Like Homeodomain 2 (PITX2) Interaktionspartner

  1. asymmetric expression of fatty acid elongase 6 gene is controlled by left right Nodal signaling and is independent of Pitx2 function in zebrafish

  2. This study found PITX2 to be decreased in patients with sustained Atrial Fibrillation, suggesting a PITX2 loss of function mechanism in Atrial Fibrillation.

  3. Antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. Restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry.

  4. Pitx2, implicated in left-right asymmetry, possessed appropriate 'atypical' Pegasus (zeige IKZF5 Proteine) binding sites in its promoter.

  5. Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b.

  6. Pitx2 is essential for proper eye and craniofacial development in zebrafish.

  7. Retinoic acid regulation of pitx2 is essential for coordinating interactions among neural crest, mesoderm, and developing eye.

  8. Zebrafish pitx2 demonstrates conserved expression during ocular and craniofacial development. Thirteen conserved noncoding sequences positioned within a gene desert as far as 1.1 Mb upstream of the human PITX2

PITX2 Protein Überblick

Protein Überblick

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with PITX2

  • paired-like homeodomain 2 (PITX2)
  • paired-like homeodomain 2 (pitx2-a)
  • paired-like homeodomain 2 (pitx2)
  • paired-like homeodomain transcription factor 2 (pitx-2)
  • paired-like homeodomain 3 (PITX3)
  • paired-like homeodomain 2 (Pitx2)
  • paired-like homeodomain 2 (pitx2-b)
  • paired-like homeodomain transcription factor 2 (Pitx2)
  • paired-like homeodomain transcription factor 2 (pitx2)
  • 9430085M16Rik Protein
  • ARP1 Protein
  • Brx1 Protein
  • Brx1a Protein
  • Brx1b Protein
  • IDG2 Protein
  • IGDS Protein
  • IGDS2 Protein
  • IHG2 Protein
  • IRID2 Protein
  • Munc30 Protein
  • Otlx2 Protein
  • pitx-2 Protein
  • pitx2 Protein
  • pitx2-A Protein
  • pitx2a Protein
  • Pitx2b Protein
  • Pitx2c Protein
  • Pitx2cbeta Protein
  • Ptx2 Protein
  • RGS Protein
  • Rieg Protein
  • RIEG1 Protein
  • RS Protein
  • xpitx2 Protein
  • xPtx2 Protein
  • XPtx2b Protein
  • zgc:110508 Protein

Bezeichner auf Proteinebene für PITX2

paired-like homeodomain transcription factor 2 , cPITX2 , homeobox protein PITX2 , pituitary homeobox 2 , transcription factor Pitx2 , ALL1-responsive protein ARP1 , all1-responsive gene 1 , rieg bicoid-related homeobox transcription factor 1 , solurshin , homeodomain transcription factor 2 , rPtx2 , homeodomain transcription factor Pitx2 , BRX1 homeoprotein , orthodenticle-like homeobox 2 , paired-like homeodomain transcription factor Munc 30 , paired-like homeodomain transcription factor 2a , pitx2b

GENE ID SPEZIES
100146441 Equus caballus
373586 Xenopus laevis
461438 Pan troglodytes
549981 Xenopus (Silurana) tropicalis
100136226 Oncorhynchus mykiss
100222601 Taeniopygia guttata
100226017 Taeniopygia guttata
395862 Gallus gallus
5308 Homo sapiens
487902 Canis lupus familiaris
506721 Bos taurus
54284 Rattus norvegicus
398033 Xenopus laevis
18741 Mus musculus
30164 Danio rerio
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