Regulator of Calcineurin 1 Proteine (RCAN1)

Regulator of Calcineurin 1 Proteine (RCAN1)
Auf finden Sie aktuell 16 Regulator of Calcineurin 1 (RCAN1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Regulator of Calcineurin 1 Antikörper (172) und Regulator of Calcineurin 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 207 Regulator of Calcineurin 1 Produkte verfügbar.
2410048A02Rik, AA408855, Adapt78, AI429645, AL024459, AV028423, CALP1L, CDHF1, CSP1, DG2/DG3, DSC1, Dscr1, Mcip1, MGC53636, MGC69428, rcan1, RCN1, wu:fr92c05
alle Proteine anzeigen Gen GeneID UniProt
RCAN1 1823 Q08554
RCAN1 54720 Q9JHG6
Ratte RCAN1 RCAN1 266766 Q6IN33

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Weitere Proteine zu Regulator of Calcineurin 1 Interaktionspartnern

Xenopus laevis Regulator of Calcineurin 1 (RCAN1) Interaktionspartner

  1. RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.

Human Regulator of Calcineurin 1 (RCAN1) Interaktionspartner

  1. RCAN1.4 prevents cell proliferation, migration, and invasion in vitro; overexpressed RCAN1.4 in HCC (zeige FAM126A Proteine) cells prevents growth, angiogenesis, and metastases of xenograft tumors by inhibiting calcineurin (zeige PPP3CA Proteine) activity and nuclear translocation of NFAT1 (zeige NFAT1 Proteine).

  2. elucidated a novel function of regulator of calcineurin 1 isoform 1 in mitochondria and provides a molecular basis for the regulator of calcineurin 1 isoform over-expression-induced mitochondrial dysfunctions and neuronal apoptosis

  3. our research revealed that RCAN1 was involved in the development of small cell lung cancer, and it might be a cancer-inhibiting gene for the formation of bone metastases in small cell lung cancer

  4. The results of the study indicate that RCAN1 is suppressed in endothelial cells of chronically inflamed periodontal tissues. During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues.

  5. mRNA expression levels of DSCR1 and VEGF-C (zeige VEGFC Proteine), and microvessel density are increased in cancerous tissues, compared with paracancerous tissue in hypopharyngeal cancer.

  6. DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing

  7. Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.

  8. The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (zeige CHDH Proteine)) susceptibility.

  9. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease

  10. RCAN1 can interact with IkappaBalpha (zeige NFKBIA Proteine) and affect the phosphorylation of IkappaBalpha (zeige NFKBIA Proteine) at tyrosine 42.

Mouse (Murine) Regulator of Calcineurin 1 (RCAN1) Interaktionspartner

  1. The present study demonstrates that RCAN1 deficiency protects against Salmonella intestinal infection by enhancing proinflammatory JNK (zeige MAPK8 Proteine) signaling.

  2. DSCR1 as a key protein that couples axon growth.

  3. from amongst the myriad of gene expression changes occurring in Type 2 diabetes (T2D) b-cells where we had little knowledge of which changes cause b-cell dysfunction, we applied a trisomy 21 screening approach which linked RCAN1 to b (zeige TDO2 Proteine)-cell mitochondrial dysfunction in T2D.

  4. These results uncover a critical link between calcineurin (zeige PPP3CA Proteine) signalling, impaired neurotrophin (zeige BDNF Proteine) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.

  5. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.

  6. inhibition of the calcineurin (zeige PPP3CA Proteine)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo

  7. PACAP (zeige ADCYAP1 Proteine) targets RCAN1 to control neuronal differentiation.

  8. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (zeige NFATC1 Proteine)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (zeige PPP3CA Proteine) activity in HEK293T cells

  9. found that RCAN1/3 interact with RAF (zeige RAF1 Proteine) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (zeige RAF1 Proteine) kinases may influence T cell positive selection

  10. Calcineurin (zeige PPP3CA Proteine) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.

Regulator of Calcineurin 1 (RCAN1) Protein Überblick

Protein Überblick

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Alternative names and synonyms associated with Regulator of Calcineurin 1 (RCAN1)

  • regulator of calcineurin 1 (RCAN1)
  • regulator of calcineurin 1b (rcan1b)
  • Down syndrome critical region gene 1 (dscr1)
  • regulator of calcineurin 1 (rcan1)
  • desmocollin 1 (DSC1)
  • DSCR1-like protein (LOC443255)
  • regulator of calcineurin 1 (Rcan1)
  • 2410048A02Rik Protein
  • AA408855 Protein
  • Adapt78 Protein
  • AI429645 Protein
  • AL024459 Protein
  • AV028423 Protein
  • CALP1L Protein
  • CDHF1 Protein
  • CSP1 Protein
  • DG2/DG3 Protein
  • DSC1 Protein
  • Dscr1 Protein
  • Mcip1 Protein
  • MGC53636 Protein
  • MGC69428 Protein
  • rcan1 Protein
  • RCN1 Protein
  • wu:fr92c05 Protein

Bezeichner auf Proteinebene für RCAN1

regulator of calcineurin 1 , Down syndrome critical region gene 1 , cadherin family member 1 , desmocollin-1 , desmosomal glycoprotein 2/3 , calcipressin-1 , down syndrome critical region protein 1 , Down syndrome candidate region 1 , calcium and oxidant-inducible mRNA , modulatory calcineurin-interacting protein 1 , myocyte-enriched calcineurin-interacting protein 1 , near DSCR proline-rich protein , Down syndrome critical region homolog 1 , calcineurin inhibitor , calcipressin 1 , down syndrome critical region protein 1 homolog , myocyte-enriched calcineurin interactin protein 1 , Down syndrome critical region protein 1 homolog , Oxidative-induced protein Adapt78

697108 Macaca mulatta
336348 Danio rerio
380353 Xenopus laevis
448016 Xenopus (Silurana) tropicalis
1823 Homo sapiens
443255 Ovis aries
1827 Homo sapiens
54720 Mus musculus
379550 Xenopus laevis
418510 Gallus gallus
607887 Canis lupus familiaris
539640 Bos taurus
266766 Rattus norvegicus
100171642 Pongo abelii
100689474 Cricetulus griseus
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