CTGF Proteine (CTGF)

Auf www.antikoerper-online.de finden Sie aktuell 75 Connective Tissue Growth Factor (CTGF) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CTGF Antikörper (241) und CTGF Kits (87) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 409 CTGF Produkte verfügbar.
Synonyme:
CCN2, ccn5, ct58, CTGF, ctgf-l, CTGRP, fisp-12, Fisp12, HCS24, hm:zeh1559, IGFBP8, NOV2, si:ch211-173b8.2, si:dkey-266k12.4, wu:fl25c03, XCTGF, zeh1559, zgc:136644
alle Proteine anzeigen Gen GeneID UniProt
CTGF 14219 P29268
CTGF 1490 P29279
CTGF 64032 Q9R1E9

CTGF Proteine (CTGF) nach Spezies

Weitere Proteine zu CTGF Interaktionspartnern

Rhesus Monkey Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.

Zebrafish Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.

  2. this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.

  3. CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development

Mouse (Murine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.

  2. CTGF role in cardiac fibrosis. Long noncoding RNA H19 (zeige NCKAP1 Proteine) mediates CTGF expression.

  3. Notch1 (zeige NOTCH1 Proteine) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (zeige NOTCH1 Proteine) intracellular domain (NICD (zeige NOTCH1 Proteine)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (zeige NOTCH1 Proteine), not Notch3 (zeige NOTCH3 Proteine), directly modulates the expression of CTGF

  4. these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad (zeige SMAD1 Proteine) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (zeige LMNA Proteine) cardiomyopathy.

  5. the mechanistic target of rapamycin (mTOR (zeige FRAP1 Proteine)) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC (zeige SLC12A3 Proteine)).

  6. CCN2 suppression by miR (zeige MLXIP Proteine)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (zeige MLXIP Proteine)-199a-5p in exosomes from quiescent HSCs.

  7. In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 (zeige BMP6 Proteine) and lower CTGF expression.

  8. Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.

  9. beta-catenin (zeige CTNNB1 Proteine) signaling inhibition protects against CTGF-induced alveolar and vascular pathology in neonatal mouse lung

  10. CTGF and beta-catenin (zeige CTNNB1 Proteine) are involved in the epithelial-mesenchymal transition of podocytes in diabetes. CTGF mediates high-glucose induced EMT (zeige ITK Proteine) through activation of beta-catenin (zeige CTNNB1 Proteine) in podocytes.

Human Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. The present findings indicate that genetic variation in CTGF may contribute to the attainment of extreme old age in Japanese.

  2. SC-derived CCN2 partially accelerated tumor growth in vitro.

  3. We document for the first time a functional role of CTGF in altering disease progression in a lymphoid malignancy. The findings provide support for targeting the bone marrow microenvironment in aggressive forms of leukaemia.

  4. CCN2 suppression by miR (zeige MLXIP Proteine)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (zeige MLXIP Proteine)-199a-5p in exosomes from quiescent HSCs.

  5. Data suggest that CTGF could be involved in oncogenic pathways promoting non-viral hepatocellular carcinoma associated with metabolic risk factors via induction of liver inflammation.

  6. MEKK1/MEK1 (zeige MAP2K1 Proteine)/ERK1 (zeige MAPK3 Proteine)/GLI-1/GLI (zeige GLI1 Proteine)-2, and AP-1 (zeige FOSB Proteine) pathways mediated hypoxia-induced CTGF expression in human lung fibroblasts.

  7. Data show that the expression of Interleukin-8 (IL-8 (zeige IL8 Proteine)) and connective tissue growth factor (CTGF) was significantly reduced by treatment with vemurafenib and trametinib in (V600E)BRAF (zeige BRAF Proteine) protein melanoma cells.

  8. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin (zeige GAST Proteine) induces expression of CTGF in gastric epithelial cells.

  9. We found significantly more positively expressed Connective Tissue Growth Factor protein in Esophageal Squamous Cell Carcinoma tissues was than in normal adjacent esophageal tissues. MiR (zeige MLXIP Proteine)-145 inhibited the proliferation, migration, invasiveness, and the EMT (zeige ITK Proteine) process of Esophageal Squamous Cell Carcinoma cells through targeted regulation of Connective Tissue Growth Factor expression.

  10. The expression of inflammatory markers in the conjunctiva of trachomatous trichiasis patients were studied; CTGF, S100A7 (zeige S100A7 Proteine), and IL-1beta (zeige IL1B Proteine) were all increased.

Pig (Porcine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.

  2. Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.

  3. CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.

  4. CTGF level was not altered in model of obliterative bronchiolitis.

Cow (Bovine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. The results indicate that CTGF suppresses the synthesis of biglycan (zeige BGN Proteine) but newly induced that of decorin (zeige DCN Proteine) in the cells when the cell density is low.

  2. Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability

Rabbit Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. A significant increase in TGF-beta1 (zeige TGFB1 Proteine) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.

  2. Stretch is an important primary trigger for CTGF-induction in the overloaded heart.

  3. Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.

  4. TGF-beta1 (zeige TGFB1 Proteine) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.

  5. Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.

Xenopus laevis Connective Tissue Growth Factor (CTGF) Interaktionspartner

  1. Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (zeige SOX2 Proteine)-, GFAP (zeige GFAP Proteine)-and GFAP (zeige GFAP Proteine)/Nestin (zeige NES Proteine)-positive cells, activated p44 (zeige GTF2H2 Proteine)/42 signaling, and upregulated fibronectin (zeige FN1 Proteine). In human glioma cells, it induced GFAP (zeige GFAP Proteine) and nestin (zeige NES Proteine).

  2. Data show that connective-tissue growth factor regulates signalling through the Wnt (zeige WNT2 Proteine) pathway, in accord with its ability to bind to the Wnt (zeige WNT2 Proteine) co-receptor LDL receptor (zeige LDLR Proteine)-related protein 6 (LRP6 (zeige LRP6 Proteine)).

CTGF Protein Überblick

Protein Überblick

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Alternative names and synonyms associated with CTGF

  • WNT1 inducible signaling pathway protein 2 (wisp2)
  • connective tissue growth factor (ctgf)
  • connective tissue growth factor (CTGF)
  • connective tissue growth factor b (ctgfb)
  • Connective tissue growth factor (ctgf)
  • connective tissue growth factor (Ctgf)
  • connective tissue growth factor (CCN2)
  • connective tissue growth factor a (ctgfa)
  • connective tissue growth factor-like (LOC476202)
  • CCN2 Protein
  • ccn5 Protein
  • ct58 Protein
  • CTGF Protein
  • ctgf-l Protein
  • CTGRP Protein
  • fisp-12 Protein
  • Fisp12 Protein
  • HCS24 Protein
  • hm:zeh1559 Protein
  • IGFBP8 Protein
  • NOV2 Protein
  • si:ch211-173b8.2 Protein
  • si:dkey-266k12.4 Protein
  • wu:fl25c03 Protein
  • XCTGF Protein
  • zeh1559 Protein
  • zgc:136644 Protein

Bezeichner auf Proteinebene für CTGF

WNT1 inducible signaling pathway protein 2 , connective tissue growth factor , zCTGF-c19 , Connective tissue growth factor , connective tissue growth factor-like , CCN family member 2 , Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24) , fibroblast inducible secreated protein , fibroblast inducible secreted protein , hypertrophic chondrocyte-specific gene product 24 , hypertrophic chondrocyte-specific protein 24 , IBP-8 , IGF-binding protein 8 , IGFBP-8 , insulin-like growth factor-binding protein 8 , connective tissue growth-related protein , connective tissue growth factor XCTGF , zCTGF-c20

GENE ID SPEZIES
496678 Xenopus (Silurana) tropicalis
548598 Xenopus (Silurana) tropicalis
714520 Macaca mulatta
100124530 Danio rerio
100137400 Papio anubis
100194970 Salmo salar
100437145 Pongo abelii
100604830 Nomascus leucogenys
14219 Mus musculus
1490 Homo sapiens
64032 Rattus norvegicus
374135 Gallus gallus
100152141 Sus scrofa
281103 Bos taurus
100303607 Ovis aries
100008638 Oryctolagus cuniculus
100726380 Cavia porcellus
398003 Xenopus laevis
463003 Pan troglodytes
321449 Danio rerio
476202 Canis lupus familiaris
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