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Findings suggest that the ABCG1 (zeige ABCG1 Antikörper)-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I bound to reconstituted HDL (zeige HSD11B1 Antikörper). Although the mid region alone of apoA-I associated to rHDL can promote ABCG1 (zeige ABCG1 Antikörper)-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I diminishes ABCG1 (zeige ABCG1 Antikörper)-mediated cholesterol efflux.
Low APOA1 expression is associated with coronary artery disease severity.
Data suggest that activation of SR-BI (zeige SCARB1 Antikörper) by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (zeige S1PR2 Antikörper)-mediated inflammation in vascular endothelial cells by activating the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway; oxidized-LDL does the opposite. (APOA1 = apolipoprotein A-I; SR-BI/SCARB1 (zeige SCARB1 Antikörper) = scavenger receptor class B type I; S1PR2 (zeige S1PR2 Antikörper) = sphingosine 1-phosphate receptor 2 (zeige S1PR2 Antikörper); PI3K (zeige PIK3CA Antikörper) = phosphatidylinositol 3-kinase; Akt (zeige AKT1 Antikörper) = proto-oncogene c-akt (zeige AKT1 Antikörper))
The minor alleles of rs662799 (APOA5 (zeige APOA5 Antikörper)) and rs5072 (APOA1) modulate TG levels in Mexican children
Objective of this study was to understand their structural and functional role by generating domain swapped chimeras: apoE3-N-terminal/apoAI-C-terminal and apoAI-N-terminal/apoE (zeige APOE Antikörper)-C-terminal. Results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that N-terminal-C-terminal domain interactions significantly modulate their structure and function.
These data demonstrate that complex of PPARgamma (zeige PPARG Antikörper) with GW1929 is a negative regulator involved in the control of ApoA-I expression and secretion in human hepatocyte- and enterocyte-like cells
Human apoA-I was overexpressed by transfection in BEL (zeige LHX2 Antikörper)-7402 hepatocytes and by an adenoviral vector in C57BL/6J mice fed a methionine choline-deficient diet. The overexpression of apoA-I in both models resulted in decreased reactive oxygen species and lipid peroxidation levels, as well as a reduced MAPK (zeige MAPK1 Antikörper) phosphorylation and decreased expression levels of c-Fos and COX-2 (zeige COX2 Antikörper).
The H10B sequence repeat of lipid-free human apoA-I is vital in HDL (zeige HSD11B1 Antikörper) formation.
Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.
these data highlight a key role of the P2Y1 (zeige P2RY1 Antikörper)/PI3Kbeta axis in endothelial cell proliferation downstream of ecto (zeige TRIM33 Antikörper)-F1-ATPase (zeige DNAH8 Antikörper) activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection.
apoA-I/ABCA1 (zeige ABCA1 Antikörper)-mediated cholesterol efflux without STAT3 (zeige STAT3 Antikörper) activation can reduce proinflammatory cytokine expression in macrophages.
a novel protective role for ApoA-I in colitis and CAC (zeige SLC25A20 Antikörper)
Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (zeige TNF Antikörper)-induced inhibition of HTR (zeige F2R Antikörper)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.
Reductions in Dio1 (zeige DIO1 Antikörper) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (zeige PTH Antikörper) response element-independent manner.
apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality
This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (zeige ABCA1 Antikörper) expression and ABCA1 (zeige ABCA1 Antikörper)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (zeige CD36 Antikörper) expression either.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (zeige HSD11B1 Antikörper)-SAA (zeige SAA1 Antikörper) particles detected multiple crosslinks between apoA1 and SAA (zeige SAA1 Antikörper), indicating close proximity (within 25 A) of these two proteins on the HDL (zeige HSD11B1 Antikörper) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (zeige SAA1 Antikörper).
results demonstrate that double deletion of Apoe (zeige APOE Antikörper) and Apoa1 ameliorated the amyloid pathology.
study suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK (zeige PRKAA1 Antikörper) dependent mitochondrial biogenesis.
Alterations in the Apo A (zeige APOA Antikörper)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (zeige APOA Antikörper)-I were observed in Salmonella typhimurium and Escherichia coli infections.
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (zeige IL6 Antikörper) and tumor necrosis factor-alpha (zeige TNF Antikörper)
This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
The molar ratio ApoE (zeige APOE Antikörper)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
Binding of apoA-I to ectopic F(0)F(1) ATPase (zeige ATP5E Antikörper) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (zeige P2RY1 Antikörper)(12) stimulates the uptake and transport of HDL (zeige HSD11B1 Antikörper) and initially lipid-free apoA-I by endothelial cells.
the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (zeige ABCA1 Antikörper) and then further processed by ABCA1 (zeige ABCA1 Antikörper)-independent mechanisms.
insulin (zeige INS Antikörper) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
, apolipoprotein A-I-like
, apolipoprotein A-I preproprotein
, apolipoprotein A1
, apolipoprotein A-1
, preproapolipoprotein A-I
, Apolipoprotein A1
, Apolipoprotein A-I