anti-ALAS1 (ALAS1) Antikörper

Bezeichnung:
anti-Aminolevulinate, delta-, Synthase 1 Antikörper (ALAS1)
Auf www.antikoerper-online.de finden Sie aktuell 58 Aminolevulinate, delta-, Synthase 1 (ALAS1) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ALAS1 Kits (8) und ALAS1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 77 ALAS1 Produkte verfügbar.
Synonyme:
ALAS, Alas-1, Alas-h, ALAS-N, ALAS1, ALAS3, ALASH, ALASN, MIG4, wu:fb58d01, wu:fi12g09

Meistgesuchte Reaktivitäten zu anti-ALAS1 (ALAS1) Antikörper

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anti-Human ALAS1 Antikörper:

anti-Rat (Rattus) ALAS1 Antikörper:

anti-Mouse (Murine) ALAS1 Antikörper:

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Am meisten referenzierte anti-ALAS1 Antikörper

  1. Human Polyclonal ALAS1 Primary Antibody für IHC (p), SimWes - ABIN252387 : Zheng, Shan, Lambrecht, Donohue, Bonkovsky: Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. in Molecular and cellular biochemistry 2008 (PubMed)
    Zeige alle 3 Referenzen für 252387

  2. Cow (Bovine) Polyclonal ALAS1 Primary Antibody für WB - ABIN2785663 : Jung, Ohl, Stephan, Rabien, Kristiansen, Radonić, Loening, Jung: [Quantifying gene expression in prostate carcinoma. Which endogenous reference genes are suitable?]. in Der Urologe. Ausg. A 2007 (PubMed)

  3. Human Monoclonal ALAS1 Primary Antibody für WB - ABIN2477319 : Leick, Wojtaszewski, Johansen, Kiilerich, Comes, Hellsten, Hidalgo, Pilegaard: PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. in American journal of physiology. Endocrinology and metabolism 2008 (PubMed)

Weitere Antikörper gegen ALAS1 Interaktionspartner

Human Aminolevulinate, delta-, Synthase 1 (ALAS1) Interaktionspartner

  1. the heme-binding site in the N-terminal region of the mature ALAS1 protein is also necessary for the heme-dependent oxidation of ALAS1.

  2. ALAS1 mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)

  3. These results indicate that ALAS1 is a novel NR5A-target gene and participates in steroid hormone production.

  4. Lon (zeige LONP1 Antikörper) peptidase 1 (zeige CNDP2 Antikörper) (LONP1 (zeige LONP1 Antikörper))-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.

  5. REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA (zeige OXCT1 Antikörper) synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia.

  6. ALAS expression is regulated by AP-1 (zeige FOSB Antikörper) complex through sequestration of cAMP-response element protein (CRE)-binding protein (CBP (zeige CREBBP Antikörper)) coactivator in human cells

  7. ALAS gene expression is regulated by Hepatic nuclear factor 3 and nuclear factor 1

  8. First described frameshift ALAS2 (zeige ALAS2 Antikörper) mutation, CD506-507 (-C).

  9. in the liver of Acute liver failure patients, there may be an increase in free heme concentration which down-regulating ALAS1 gene expression

  10. Alternative splicing of human ALAS1 generates two mRNAs with different 5'-UTRs: a major one, where exon 1B is omitted, and a minor form containing exon 1B.

Mouse (Murine) Aminolevulinate, delta-, Synthase 1 (ALAS1) Interaktionspartner

  1. RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.

  2. Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt (zeige AKT1 Antikörper) phosphorylation and increased nuclear FOXO1 (zeige FOXO1 Antikörper), PGC-1alpha (zeige PPARGC1A Antikörper) and FOXO1 (zeige FOXO1 Antikörper)-PGC-1alpha (zeige PPARGC1A Antikörper) complex levels.

  3. Egr-1 (zeige EGR1 Antikörper) regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme

  4. Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis.

  5. Ser (zeige SIGLEC1 Antikörper)-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA (zeige OXCT1 Antikörper) binding to enzyme conformational equilibria

  6. identified a drug-responsive enhancer in the ALAS1 gene

  7. Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP (zeige C3 Antikörper))-binding and catalysis.

  8. The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR (zeige UTS2R Antikörper) regions contribute to inter-individual differences in gene expression.

ALAS1 Antigen-Profil

Beschreibung des Gens

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme\; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with ALAS1

  • aminolevulinate, delta-, synthase 1 (ALAS1) Antikörper
  • aminolevulinate, delta-, synthase 1 (alas1) Antikörper
  • alanyl-tRNA synthetase domain-containing protein (alaS1) Antikörper
  • alanyl-tRNA synthetase protein (alaS1) Antikörper
  • aminolevulinate, delta-, synthase 1 pseudogene (ALAS1) Antikörper
  • aminolevulinate, delta-, synthase 1 pseudogene (LOC100420897) Antikörper
  • aminolevulinate, delta-, synthase 1 (Alas1) Antikörper
  • aminolevulinate, delta-, synthetase 1 (alas1) Antikörper
  • aminolevulinic acid synthase 1 (Alas1) Antikörper
  • ALAS Antikörper
  • Alas-1 Antikörper
  • Alas-h Antikörper
  • ALAS-N Antikörper
  • ALAS1 Antikörper
  • ALAS3 Antikörper
  • ALASH Antikörper
  • ALASN Antikörper
  • MIG4 Antikörper
  • wu:fb58d01 Antikörper
  • wu:fi12g09 Antikörper

Bezeichner auf Proteinebene für ALAS1

aminolevulinate, delta, synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial , aminolevulinate, delta-, synthase 1 , 5-aminolevulinic acid synthase 1 , Delta-ALA synthetase , delta-ALA synthase 1 , delta-aminolevulinate synthase 1 , 5-aminolevulinate synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial-like , alanyl-tRNA synthetase domain-containing protein , alanyl-tRNA synthetase protein , 5-aminolevulinic acid synthase , ALAS-H , migration-inducing protein 4 , delta-ALA synthetase 1 , ALA-S , ALAS-N , aminolevulinic acid synthase 1 , delta-ALA synthetase , ALA-synthase , aminolevulinate synthase 1 , aminolevulinate synthase H , succinyl-CoA: glycine C-succinyl transferase

GENE ID SPEZIES
460416 Pan troglodytes
493434 Xenopus (Silurana) tropicalis
698093 Macaca mulatta
100031030 Monodelphis domestica
100060491 Equus caballus
100172808 Pongo abelii
100231674 Taeniopygia guttata
100345847 Oryctolagus cuniculus
100388038 Callithrix jacchus
100473179 Ailuropoda melanoleuca
100607410 Nomascus leucogenys
5821016 Bordetella petrii DSM 12804
6399949 Rhizobium etli CIAT 652
100307125 Sus scrofa
100420897 Homo sapiens
444480 Xenopus laevis
211 Homo sapiens
476600 Canis lupus familiaris
534286 Bos taurus
65155 Rattus norvegicus
552895 Gallus gallus
101112853 Ovis aries
64608 Danio rerio
11655 Mus musculus
Ausgewählte Anbieter für anti-ALAS1 (ALAS1) Antikörper
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