anti-DISC1 (DISC1) Antikörper

anti-Disrupted in Schizophrenia 1 Antikörper (DISC1)
Auf finden Sie aktuell 189 Disrupted in Schizophrenia 1 (DISC1) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DISC1 Proteine (9) und DISC1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 213 DISC1 Produkte verfügbar.
C1orf136, DISC1, SCZD9

Meistgesuchte Reaktivitäten zu anti-DISC1 (DISC1) Antikörper

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anti-Human DISC1 Antikörper:

anti-Mouse (Murine) DISC1 Antikörper:

anti-Rat (Rattus) DISC1 Antikörper:

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Am meisten referenzierte anti-DISC1 Antikörper

  1. Human Polyclonal DISC1 Primary Antibody für EIA, WB - ABIN492932 : Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008 (PubMed)
    Zeige alle 3 Referenzen für 492932

  2. Human Polyclonal DISC1 Primary Antibody für EIA, FACS - ABIN951917 : Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Zeige alle 3 Referenzen für 951917

  3. Human Polyclonal DISC1 Primary Antibody für FACS, IHC (p) - ABIN658716 : Raznahan, Lee, Long, Greenstein, Clasen, Addington, Rapoport, Giedd: Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. in Molecular psychiatry 2011 (PubMed)
    Zeige alle 3 Referenzen für 658716

  4. Mouse (Murine) Polyclonal DISC1 Primary Antibody für ICC, IHC (fro) - ABIN258331 : El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014 (PubMed)

  5. Human Polyclonal DISC1 Primary Antibody für IHC (fro), WB - ABIN2473343 : Taya, Shinoda, Tsuboi, Asaki, Nagai, Hikita, Kuroda, Kuroda, Shimizu, Hirotsune, Iwamatsu, Kaibuchi: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  6. Human Polyclonal DISC1 Primary Antibody für ELISA, WB - ABIN190904 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

Weitere Antikörper gegen DISC1 Interaktionspartner

Zebrafish Disrupted in Schizophrenia 1 (DISC1) Interaktionspartner

  1. A Disc1 peptide binds to GSK3beta (zeige GSK3b Antikörper), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (zeige CTNNB1 Antikörper)-mediated Wnt (zeige WNT2 Antikörper) signaling and inhibiting GSK3beta (zeige GSK3b Antikörper) activity.

  2. Disc1 and nrg1 (zeige NRG1 Antikörper) function in controlling development of oligodendrocytes and neurones from olig2 (zeige OLIG2 Antikörper)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (zeige FOXD3 Antikörper) and sox10 (zeige SOX10 Antikörper), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) Interaktionspartner

  1. HTT (zeige HTT Antikörper) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (zeige PDE4A Antikörper)) to regulate PDE4 (zeige PDE4A Antikörper) activity.

  2. This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.

  3. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (zeige CHL1 Antikörper) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  4. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.

  5. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (zeige GSK3b Antikörper) phosphorylation.

  6. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations

  7. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses

  8. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (zeige NRG1 Antikörper) genes could be associated with schizophrenia in the Chinese population.

  9. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  10. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) Interaktionspartner

  1. Co-disruption of DISC1 and NRG1 (zeige NRG1 Antikörper), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (zeige AVP Antikörper) gene expression in a mouse schizophrenia model.

  2. the 100P mutation in Disc1 prevents expression of parvalbumin (zeige PVALB Antikörper) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (zeige PVALB Antikörper) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.

  3. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons

  4. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  5. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (zeige GSK3b Antikörper) signaling and sex-dependent behavioral effects in mice

  6. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  7. Hypoxic preconditioning decreases NF-kappaB (zeige NFKB1 Antikörper) activity via Disc1.

  8. Results indicate that DISC1 attenuates Abeta (zeige APP Antikörper) generation and cognitive deficits of APP (zeige APP Antikörper)/PS1 (zeige PSEN1 Antikörper) transgenic mice through promoting lysosomal degradation of BACE1 (zeige BACE Antikörper)

  9. These results suggest that alteration of CB1R (zeige CNR1 Antikörper)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  10. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

DISC1 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with DISC1

  • disrupted in schizophrenia 1 (disc1) Antikörper
  • disrupted in schizophrenia 1 (DISC1) Antikörper
  • disrupted in schizophrenia 1 (Disc1) Antikörper
  • C1orf136 Antikörper
  • DISC1 Antikörper
  • SCZD9 Antikörper

Bezeichner auf Proteinebene für DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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