anti-APOE (APOE) Antikörper

Bezeichnung:
anti-Apolipoprotein E Antikörper (APOE)
Auf www.antikoerper-online.de finden Sie aktuell 354 Apolipoprotein E (APOE) Antikörper von 31 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APOE Kits (120) und APOE Proteine (52) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 539 APOE Produkte verfügbar.
Synonyme:
AD2, AI255918, Apo-E, apoe, APOEA, apoprotein, im:7036787, LDLCQ5, LPG, wu:fb69a05, zgc:110064

Meistgesuchte Reaktivitäten zu anti-APOE (APOE) Antikörper

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anti-Mouse (Murine) APOE Antikörper:

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anti-Rat (Rattus) APOE Antikörper:

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Am meisten referenzierte anti-APOE Antikörper

  1. Human Monoclonal APOE Primary Antibody für CyTOF, ELISA - ABIN258785 : Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 10 Referenzen für 258785

  2. Human Polyclonal APOE Primary Antibody für IHC, WB - ABIN2774066 : Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008 (PubMed)
    Zeige alle 4 Referenzen für 2774066

  3. Human Monoclonal APOE Primary Antibody für EIA, IHC (fro) - ABIN1105420 : Dergunov, Shuvaev, Yanushevskaja: Quaternary structure of apolipoprotein E in solution: fluorimetric, chromatographic and immunochemical studies. in Biological chemistry Hoppe-Seyler 1992 (PubMed)
    Zeige alle 2 Referenzen für 1105420

  4. Human Polyclonal APOE Primary Antibody für IHC (p), ELISA - ABIN1997537 : Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013 (PubMed)
    Zeige alle 2 Referenzen für 1997537

  5. Human Polyclonal APOE Primary Antibody für IHC, ELISA - ABIN185375 : Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Zeige alle 2 Referenzen für 185375

  6. Human Polyclonal APOE Primary Antibody für IHC (p), WB - ABIN391849 : Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. in Hepatology (Baltimore, Md.) 2009 (PubMed)

  7. Human Polyclonal APOE Primary Antibody für IF (p), IHC (p) - ABIN1386767 : Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014 (PubMed)

  8. Mouse (Murine) Polyclonal APOE Primary Antibody für IF (p), IHC (p) - ABIN725750 : Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015 (PubMed)

Weitere Antikörper gegen APOE Interaktionspartner

Mouse (Murine) Apolipoprotein E (APOE) Interaktionspartner

  1. treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4

  2. Adiponectin (zeige ADIPOQ Antikörper), TNF-alpha (zeige TNF Antikörper), and LOX-1 (zeige OLR1 Antikörper) exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE knockout mice.

  3. Apoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism. [review]

  4. beta-Sarcoglycan (zeige SGCB Antikörper) deficiency reduces atherosclerotic plaque formation in ApoE-knockout mouse model.

  5. we found that the lack of microbiota caused a significant reduction in atherosclerotic lesion formation compared with Conv ApoE(-/-) mice, which might be associated with the attenuation of lipopolysaccharide-mediated inflammatory responses. Our findings indicated that the gut (zeige GUSB Antikörper) microbiota affected both hypercholesterolemia and atherogenesis in mice

  6. this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 (zeige CX3CR1 Antikörper) on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts

  7. Specific inhibition of the NLRP3 (zeige NLRP3 Antikörper) inflammasome using MCC950 can be a promising therapeutic approach to inhibit atherosclerotic lesion development in ApoE deficient mice.

  8. catK (zeige CTSK Antikörper) deficiency almost completely blunted the increased vascular remodeling response of apoE-/- mice to flow cessation, possibly by correcting hyperlipidemia-associated pro-inflammatory effects on the peripheral immune response

  9. High fat intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  10. The levels of EZH2 (zeige EZH2 Antikörper) and H3K27me3 were increased in the aorta of ApoE-/- mice fed a high-methionine diet for 16 weeks, whereas miR (zeige MLXIP Antikörper)-92a expression was decreased.

Human Apolipoprotein E (APOE) Interaktionspartner

  1. the identification of the e4 allele of Apolipoprotein E as a strong genetic risk factor for both early-onset and late-onset Alzheimer disease (AD) , and evolved to the more recent detection of at least 21 additional genetic risk loci for the genetically complex form of AD emerging from genome-wide association studies

  2. APOE-epsilon2 allele was more frequent in ALS patients than in controls.

  3. Study analyzed 595 older adults without dementia classified cross-sectionally as Abeta (zeige APP Antikörper)- and Abeta (zeige APP Antikörper)+ using longitudinal florbetapir positron emission tomography. APOE epsilon4 carriage and older age were predictors of longitudinal Abeta (zeige APP Antikörper) accumulation within the Abeta (zeige APP Antikörper)- group but not the Abeta (zeige APP Antikörper)+ group. APOE epsilon2 carriage was protective against longitudinal Abeta (zeige APP Antikörper) accumulation within the Abeta (zeige APP Antikörper)- group.

  4. Meta-analysis suggested that there is no association between APOE polymorphism and subarachnoid hemorrhage risk for overall population. Increased risk of SAH (zeige ACSM3 Antikörper) was found in Asian subjects when epsilon4 allele compared with epsilon3 allele.

  5. Here, we have shown that genetic restoration of plasma ApoE to wild-type levels normalizes plasma lipids in ApoE KO mice. While this does not rescue synaptic loss, it does completely restore learning and memory in the mice, suggesting that both CNS and plasma ApoE are independent parameters that affect brain health.

  6. the results of current study found a significant gene- gene interaction between rs405509 of APOE gene polymorphism and rs1805192 of PPARG (zeige PPARG Antikörper) polymorphism associated with increased Late-Onset Alzheimer's Disease risk

  7. ApoE epsilon4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

  8. Data suggest that the redox status of serum apoE might be related to the synthesis of HDL (zeige HSD11B1 Antikörper); the cysteine-thiol residue of reduced-apoE is in a naive state, while that of non-reduced-apoE is in a reversibly or irreversibly oxidized state. Data suggest that apoE homodimer and apoE-AII (zeige NLRP3 Antikörper) complex are typical reversibly oxidized forms of apoE. (apoE-AII (zeige NLRP3 Antikörper) complex = a complex of apolipoprotein E and apolipoprotein A-II (zeige APOA2 Antikörper))

  9. carriers of the ApoE varepsilon4 polymorphism genotype show demonstrable improvement in VA after treatment with ranibizumab in exudative AMD (zeige AMD1 Antikörper).

  10. Findings do not provide significant support for presenilin 1 (PSEN1 (zeige PSEN1 Antikörper)) E318G as a risk factor for Alzheimer's disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.

Rabbit Apolipoprotein E (APOE) Interaktionspartner

  1. we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.

  2. The molar ratio ApoE/ApoA-I (zeige APOA1 Antikörper) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

  3. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (zeige HSD11B1 Antikörper) paraoxonase activity

  4. The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.

Pig (Porcine) Apolipoprotein E (APOE) Interaktionspartner

  1. These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant

Cow (Bovine) Apolipoprotein E (APOE) Interaktionspartner

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (zeige APOB Antikörper), ApoE, MTP (zeige MTTP Antikörper), and LDLR (zeige LDLR Antikörper), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

  2. Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism

  3. apoE-containing particles, which increased during the lactating stage, were not associated with HDL (zeige HSD11B1 Antikörper) particles, and lipid-free forms were included in cow plasma

  4. after calving the apolipoprotein B(100 (zeige APOB Antikörper)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (zeige MTTP Antikörper)) and apolipoprotein E messenger RNA abundance were higher in the liver

Chimpanzee Apolipoprotein E (APOE) Interaktionspartner

  1. The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.

  2. ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.

Rhesus Monkey Apolipoprotein E (APOE) Interaktionspartner

  1. In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals

  2. Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world

  3. There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.

APOE Antigen-Profil

Beschreibung des Gens

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Alternative names and synonyms associated with APOE

  • apolipoprotein E (apoe) Antikörper
  • apolipoprotein Ea (apoea) Antikörper
  • apolipoprotein E (Apoe) Antikörper
  • apolipoprotein E (APOE) Antikörper
  • AD2 Antikörper
  • AI255918 Antikörper
  • Apo-E Antikörper
  • apoe Antikörper
  • APOEA Antikörper
  • apoprotein Antikörper
  • im:7036787 Antikörper
  • LDLCQ5 Antikörper
  • LPG Antikörper
  • wu:fb69a05 Antikörper
  • zgc:110064 Antikörper

Bezeichner auf Proteinebene für APOE

apolipoprotein E , ApoE-1 , apo-E , apolipoprotein E3

GENE ID SPEZIES
394678 Xenopus (Silurana) tropicalis
553587 Danio rerio
100136023 Oncorhynchus mykiss
100380959 Xenopus laevis
11816 Mus musculus
348 Homo sapiens
100009337 Oryctolagus cuniculus
25728 Rattus norvegicus
397576 Sus scrofa
100731633 Cavia porcellus
281004 Bos taurus
476438 Canis lupus familiaris
449586 Pan troglodytes
714623 Macaca mulatta
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