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MAF1 (zeige MAF1 Proteine), RNF7 and SETD3 (zeige SETD3 Proteine) are identified as PCNA (zeige PCNA Proteine)-associated proteins in human cells and given this interaction with PCNA (zeige PCNA Proteine), Maf1 (zeige MAF1 Proteine), RNF7, and SetD3 (zeige SETD3 Proteine) are potentially involved in DNA replication, DNA repair, or associated processes.
These findings indicate that Rbx1 and Rbx2 can both activate Cul5 (zeige CUL5 Proteine)-Vif (zeige BTG1 Proteine) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
SAG (zeige DMBT1 Proteine) plays an important role in regulating ionizing radiation-induced apoptosis
The findings showed that SAG (zeige DMBT1 Proteine) E3 ubiquitin ligase (zeige MUL1 Proteine) plays an essential role in cancer cell proliferation and tumor growth
SAG (zeige DMBT1 Proteine) possesses a potent peroxidase property to decompose hydrogen peroxide in the presence of dithiothreitol
sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage.
results indicate that protein kinase (zeige CDK7 Proteine) CKII (zeige CSNK2A1 Proteine) may control IkappaBalpha (zeige NFKBIA Proteine) and p27Kip1 (zeige CDKN1B Proteine) degradation and thereby G1/S phase transition through the phosphorylation of threonine 10 within CKBBP1 protein
These studies suggested that CK2 (zeige CSNK2A1 Proteine) might regulate SAG (zeige DMBT1 Proteine)-SCF (zeige KITLG Proteine) E3 ligase activity through modulating SAG's stability, rather than its enzymatic activity directly.
Endogenous levels of pro-caspase 3 (zeige CASP3 Proteine) were decreased by overexpression of SAG (zeige DMBT1 Proteine) protein.
Attenuation of SAG expression, exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy via a disruption of the cellular redox balance.
Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization.
as a novel substrate of SAG-betaTrCP (zeige BTRC Proteine) E3 ligase. By degrading Erbin (zeige ERBB2IP Proteine) and Nrf2 (zeige NFE2L2 Proteine), Sag activates the Ras-Raf (zeige RAF1 Proteine) pathway and causes ROS (zeige ROS1 Proteine) accumulation to trigger autophagy and senescence
Sag is a Kras-cooperating oncogene (zeige RAB1A Proteine) that promotes lung tumorigenesis
identifies NF1 as a physiological substrate of SAG-CUL1-FBXW7 E3 ligase and establishes a ubiquitin-dependent regulatory mechanism for the NF1-RAS pathway during embryogenesis
Thus, we concluded that SAG is a cellular protective molecule, which appears to function as an antioxidant, suppressing MPP(+)-induced neurotoxicity.
SAG accelerates ultraviolet B-induced skin hyperplasia, but not carcinogenesis.
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
CKII beta-binding protein 1
, RING-box protein 2
, regulator of cullins 2
, sensitive to apoptosis gene protein
, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
, zinc RING finger protein SAG