anti-EGLN3 (EGLN3) Antikörper

anti-Egl Nine Homolog 3 (C. Elegans) Antikörper (EGLN3)
Auf finden Sie aktuell 133 Egl Nine Homolog 3 (C. Elegans) (EGLN3) Antikörper von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen EGLN3 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 151 EGLN3 Produkte verfügbar.
2610021G09Rik, AI505553, AI648162, EGLN3, Hif-p4h-3, HIFP4H3, HIFPH3, PHD-3, Phd3, SM-20, wu:fj78a08, zgc:77019

Meistgesuchte Reaktivitäten zu anti-EGLN3 (EGLN3) Antikörper

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anti-Rat (Rattus) EGLN3 Antikörper:

anti-Mouse (Murine) EGLN3 Antikörper:

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Am meisten referenzierte anti-EGLN3 Antikörper

  1. Human Polyclonal EGLN3 Primary Antibody für EM, ICC - ABIN151073 : Bai, Zeng, Hu, Li, Lin, Shang, Shi: Expression and characteristic of synthetic human epidermal growth factor (hEGF) in transgenic tobacco plants. in Biotechnology letters 2007 (PubMed)
    Zeige alle 37 Referenzen für 151073

  2. Human Polyclonal EGLN3 Primary Antibody für ChIP, ICC - ABIN151769 : Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008 (PubMed)
    Zeige alle 35 Referenzen für 151769

  3. Human Monoclonal EGLN3 Primary Antibody für IHC, IHC (p) - ABIN447479 : Fujita, Gogate, Chiba, Toyama, Shapiro, Risbud: Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. in The Journal of biological chemistry 2012 (PubMed)
    Zeige alle 5 Referenzen für 447479

  4. Human Polyclonal EGLN3 Primary Antibody für IHC (p), WB - ABIN658142 : Sato, Sakota, Nakayama: Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia. in Experimental cell research 2010 (PubMed)
    Zeige alle 3 Referenzen für 658142

  5. Human Polyclonal EGLN3 Primary Antibody für ELISA, WB - ABIN409073 : Nakayama, Gazdoiu, Abraham, Pan, Ronai: Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. in The Biochemical journal 2006 (PubMed)

  6. Cow (Bovine) Polyclonal EGLN3 Primary Antibody für WB - ABIN2784911 : Ginouvès, Ilc, Macías, Pouysségur, Berra: PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

Weitere Antikörper gegen EGLN3 Interaktionspartner

Xenopus laevis Egl Nine Homolog 3 (C. Elegans) (EGLN3) Interaktionspartner

  1. comparative analysis of phd1 (zeige EGLN2 Antikörper), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 3 (C. Elegans) (EGLN3) Interaktionspartner

  1. Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages

  2. PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2 (zeige ACACB Antikörper).

  3. Our observations disclose a novel role of PHD3 in the development of Tregs.

  4. Epo (zeige EPO Antikörper) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 (zeige EGLN1 Antikörper) and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.

  5. deleting Phd1 (zeige EGLN2 Antikörper)-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.

  6. PHD3 is an active participant in atherogenesis

  7. Cardiomyocyte-specific transgenic expression of PHD3 impairs the myocardial response to ischemia.

  8. PHD3 protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 in stabilizing occludin (zeige OCLN Antikörper)

  9. depletion of PHD3 leads to increased stabilization of HIF-1alpha (zeige HIF1A Antikörper) and inhibition of DNA damage response, both of which may contribute to the cardioprotective effect seen with depletion of PHD3.

  10. PHD3 loss sustains cell proliferation through the control of EGFR (zeige EGFR Antikörper).

Human Egl Nine Homolog 3 (C. Elegans) (EGLN3) Interaktionspartner

  1. These findings indicate that downregulation of PHD3 and FIH (zeige CASR Antikörper) in HCC (zeige FAM126A Antikörper) is associated with more aggressive tumor behavior and a poor prognosis in hepatocellular carcinoma

  2. PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2 (zeige ACACB Antikörper).

  3. demonstrate that downregulation of PHD3 augments metastatic spread in human colorectal cancer and identify MCL-1 (zeige MCL1 Antikörper) as a novel downstream effector of oxygen sensing

  4. In pancreatic Beta cells, knock-down of PHD3 inhibited glucose-stimulated insulin (zeige INS Antikörper) secretion.

  5. Loss of PHD3 expression is associated with breast cancer.

  6. The selective efficacy of PZ was further demonstrated at the cellular level by observing inhibition of the PHD3-dependent DNA damage response pathway without stabilization of HIF-1alpha (zeige HIF1A Antikörper).

  7. The enhanced expression of PHD3 might likely contribute to the poor neovascularization and affect the biological characterization in PDAC cancer cells

  8. The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 (zeige PAK2 Antikörper) that occurs by attenuating p27S10 phosphorylation.

  9. PHD3 controls EGFR (zeige EGFR Antikörper) activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 (zeige EPS15 Antikörper) and promotes the internalization of EGFR (zeige EGFR Antikörper).

  10. PHD3 loss sustains cell proliferation through the control of EGFR (zeige EGFR Antikörper).

EGLN3 Antigen-Profil

Beschreibung des Gens

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

Alternative names and synonyms associated with EGLN3

  • egl nine homolog 3 (C. elegans) (egln3) Antikörper
  • egl nine homolog 3 (egln3) Antikörper
  • egl nine homolog 3 (LOC100354210) Antikörper
  • egl nine homolog 3 (C. elegans) (EGLN3) Antikörper
  • egl nine homolog 3 (C. elegans) (LOC100219039) Antikörper
  • EGL nine homolog 3 (C. elegans) (Egln3) Antikörper
  • egl-9 family hypoxia-inducible factor 3 (EGLN3) Antikörper
  • 2610021G09Rik Antikörper
  • AI505553 Antikörper
  • AI648162 Antikörper
  • EGLN3 Antikörper
  • Hif-p4h-3 Antikörper
  • HIFP4H3 Antikörper
  • HIFPH3 Antikörper
  • PHD-3 Antikörper
  • Phd3 Antikörper
  • SM-20 Antikörper
  • wu:fj78a08 Antikörper
  • zgc:77019 Antikörper

Bezeichner auf Proteinebene für EGLN3

Hif-p4h-3 , egl nine homolog 3 , phd3 , egl nine homolog 3 (C. elegans) , HIF-PH3 , HIF-prolyl hydroxylase 3 , HPH-3 , egl nine homolog 3, mitochondrial , factor-responsive smooth muscle protein , hypoxia-inducible factor prolyl hydroxylase 3 , prolyl hydroxylase domain-containing protein 3 , HIF prolyl hydroxylase 3 , HPH-1 , egl nine-like protein 3 isoform

406602 Danio rerio
100145602 Xenopus (Silurana) tropicalis
100354210 Oryctolagus cuniculus
452850 Pan troglodytes
480286 Canis lupus familiaris
100219039 Taeniopygia guttata
100127282 Xenopus laevis
54702 Rattus norvegicus
423316 Gallus gallus
535578 Bos taurus
112407 Mus musculus
112399 Homo sapiens
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