anti-PDPK1 (PDPK1) Antikörper

anti-3-phosphoinositide Dependent Protein Kinase-1 Antikörper (PDPK1)
Auf finden Sie aktuell 467 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antikörper von 31 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PDPK1 Proteine (28) und PDPK1 Kits (25) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 551 PDPK1 Produkte verfügbar.
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787

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Am meisten referenzierte anti-PDPK1 Antikörper

  1. Human Polyclonal PDPK1 Primary Antibody für EIA - ABIN358390 : Nilsen, Slagsvold, Skjerpen, Brech, Stenmark, Olsnes: Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 5 Referenzen für 358390

  2. Human Polyclonal PDPK1 Primary Antibody für IF, IHC (p) - ABIN196616 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005 (PubMed)
    Zeige alle 4 Referenzen für 196616

  3. Human Polyclonal PDPK1 Primary Antibody für ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014 (PubMed)
    Zeige alle 3 Referenzen für 250776

  4. Human Polyclonal PDPK1 Primary Antibody für EIA, WB - ABIN359095 : Frödin, Antal, Dümmler, Jensen, Deak, Gammeltoft, Biondi: A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. in The EMBO journal 2002 (PubMed)
    Zeige alle 3 Referenzen für 359095

  5. Human Polyclonal PDPK1 Primary Antibody für ELISA, WB - ABIN185505 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. in Science (New York, N.Y.) 2005 (PubMed)

  6. Human Polyclonal PDPK1 Primary Antibody für IHC, ELISA - ABIN1532025 : Stephens, Anderson, Stokoe, Erdjument-Bromage, Painter, Holmes, Gaffney, Reese, McCormick, Tempst, Coadwell, Hawkins: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. in Science (New York, N.Y.) 1998 (PubMed)

  7. Cow (Bovine) Polyclonal PDPK1 Primary Antibody für WB - ABIN2779320 : Lin, Hsieh, Song, Lin: Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. in British journal of cancer 2005 (PubMed)

  8. Human Polyclonal PDPK1 Primary Antibody für IF (p), IHC (p) - ABIN744668 : Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. in Epilepsy research 2015 (PubMed)

  9. Cow (Bovine) Polyclonal PDPK1 Primary Antibody für WB - ABIN2777432 : Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: Amlodipine inhibits cell proliferation via PKD1-related pathway. in Biochemical and biophysical research communications 2008 (PubMed)

Weitere Antikörper gegen PDPK1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Interaktionspartner

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (zeige CDK7 Antikörper) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Interaktionspartner

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (zeige IL1B Antikörper)pared to (zeige IL6 Antikörper)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (zeige RPS6KA3 Antikörper)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (zeige TNF Antikörper)gress of RA.

  3. PDK1 is required for Ca(2 (zeige CA2 Antikörper)+)-dependent platelet activation on stimulation of collagen receptor (zeige ITGA2 Antikörper) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Antikörper)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (zeige IRS1 Antikörper)/PDPK1/AKT (zeige AKT1 Antikörper) insulin (zeige INS Antikörper) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Antikörper) and activating PDPK1. This research may provide new insights into GTPase (zeige RACGAP1 Antikörper)-mediated insulin (zeige INS Antikörper) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Antikörper) sensitizati

  5. Only when suboptimal doses of Akt (zeige AKT1 Antikörper)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (zeige NOTCH1 Antikörper) inhibition was seen. We conclude that the Akt (zeige AKT1 Antikörper) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (zeige AKT1 Antikörper) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (zeige NFKB1 Antikörper).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (zeige BCR Antikörper)-induced signal transduction to Foxo (zeige FOXO3 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Interaktionspartner

  1. Highly expressed PDK1 (zeige PDK1 Antikörper) could promote cell invasion and secretion of IL-1beta (zeige IL1B Antikörper) and IL-6 (zeige IL6 Antikörper) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (zeige RPS6KA3 Antikörper) reduced the PDK1 (zeige PDK1 Antikörper)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (zeige TNF Antikörper), PDK1 (zeige PDK1 Antikörper) could phosphorylate RSK2 (zeige RPS6KA3 Antikörper) and activated RSK2 (zeige RPS6KA3 Antikörper), then promoting the activation of NF-kappaB (zeige NFKB1 Antikörper).

  2. In cancer cells resistant to PI3Kalpha (zeige PIK3CA Antikörper) inhibition, PDK1 (zeige PDK1 Antikörper) blockade restores sensitivity to these therapies. SGK1 (zeige SGK1 Antikörper), which is activated by PDK1 (zeige PDK1 Antikörper), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (zeige TSC2 Antikörper).

  3. Results suggest that Ser (zeige SIGLEC1 Antikörper)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (zeige PDK1 Antikörper)-PKCtheta (zeige PRKCQ Antikörper);-mediated T cell activation.

  4. Elevated expression of PDK1 (zeige PDK1 Antikörper) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (zeige MLXIP Antikörper)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (zeige PDK1 Antikörper).

  6. miR (zeige MLXIP Antikörper)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (zeige PDK1 Antikörper) expression.

  7. Decreased PDK1 (zeige PDK1 Antikörper) level is closely associated with reduced Akt (zeige AKT1 Antikörper)/cyclin D1 (zeige CCND1 Antikörper) activity.

  8. MiR (zeige MLXIP Antikörper)-138 regulation of PI3K (zeige PIK3CA Antikörper) signaling in ASMCs by altering the expression of PDK1 (zeige PDK1 Antikörper).

  9. Dephosphorylation of PDK-1 (zeige PDK1 Antikörper) and the resulting changes to Akt (zeige AKT1 Antikörper) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (zeige CLDN18 Antikörper) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (zeige CDK7 Antikörper)-1 and proto-oncogene (zeige RAB1A Antikörper) protein c (zeige PROC Antikörper)-akt (Akt (zeige AKT1 Antikörper)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Interaktionspartner

  1. miR (zeige MYLIP Antikörper)-375 directly targeted PDK1 (zeige PDK1 Antikörper) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Interaktionspartner

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (zeige PIK3C3 Antikörper) (PI3K)

PDPK1 Antigen-Profil

Beschreibung des Gens

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) Antikörper
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) Antikörper
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) Antikörper
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) Antikörper
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) Antikörper
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) Antikörper
  • Phosphoinositide-dependent kinase 1 (Pdk1) Antikörper
  • Protein PDK-1 (pdk-1) Antikörper
  • 1210 Antikörper
  • BG02759 Antikörper
  • CG1201 Antikörper
  • CG1210 Antikörper
  • Dmel\\CG1210 Antikörper
  • dPDK-1 Antikörper
  • dPDK1 Antikörper
  • dSTPK61 Antikörper
  • MGC82080 Antikörper
  • PDK Antikörper
  • PDK-1 Antikörper
  • Pdk1 Antikörper
  • PDK1/Pk61C Antikörper
  • pdpk1 Antikörper
  • PDPK2 Antikörper
  • pk61c Antikörper
  • Pk61C/PDK1 Antikörper
  • PRO0461 Antikörper
  • zgc:153787 Antikörper

Bezeichner auf Proteinebene für PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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