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anti-Mouse (Murine) PDK1 Antikörper:
anti-Human PDK1 Antikörper:
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Here, the authors show that loss of Fxn (zeige FXN Antikörper) in the nervous system in mice also activates an iron/sphingolipid/PDK1 (zeige PDPK1 Antikörper)/Mef2 (zeige MEF2C Antikörper) pathway, indicating that the mechanism is evolutionarily conserved.
PDK1 (zeige PDPK1 Antikörper) has broad effects in hematopoiesis and is a critical factor for engraftment of both hematopoietic stem cells and multipotent progenitors upon transplantation to recipient mice.
our results offer significant insight into how PIK3CA (zeige PIK3CA Antikörper) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (zeige PDPK1 Antikörper) and TGFb (zeige TGFB1 Antikörper) signaling in advanced HNSCC patients with PIK3CA (zeige PIK3CA Antikörper) amplification
PTEN (zeige PTEN Antikörper) is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (zeige PDPK1 Antikörper) is required for stabilization of apical junctions during epithelial morphogenesis.
results thus reveal an essential role for the PDK1 (zeige PDPK1 Antikörper)-Akt (zeige AKT1 Antikörper) pathway in the regulation of a key step of neuronal migration.
PDK1 (zeige PDPK1 Antikörper) plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.
Our data suggest that two arms of the glucose metabolism synergistically regulate the differential activation of macrophages. Our findings also highlight the central role of PDK1 (zeige PDPK1 Antikörper) in this event via controlling glycolysis and glucose oxidation.
PDHK1 is expressed in Th17 cells, but not Th1 (zeige HAND1 Antikörper) cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs.
The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC (zeige PDC Antikörper) binding.
Pdk1 (zeige PDPK1 Antikörper) enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis
The pyruvate dehydrogenase (zeige PDP Antikörper) kinases (PDKs) PDK1 and PDK3 (zeige PDK3 Antikörper) are direct targets of KDM4A (zeige KDM4A Antikörper) and E2F1 (zeige E2F1 Antikörper) and modulate the switch between glycolytic metabolism and mitochondrial oxidation.
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (zeige PIK3CA Antikörper) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (zeige PIK3CA Antikörper)-PDK1 signaling pathway in mediating acquired resistance to CDK4/6 (zeige CDK4 Antikörper) inhibitors.
dicumarol potently inhibited the kinase activity of PDK1, shifted the glucose metabolism from aerobic glycolysis to oxidative phosphorylation, generated a higher level of reactive oxygen species (ROS (zeige ROS1 Antikörper)), attenuated the mitochondrial membrane potential (MMP), induced apoptosis, and reduced cell viability in vitro.
our results offer significant insight into how PIK3CA (zeige PIK3CA Antikörper) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (zeige PIK3CA Antikörper)/PDK1 and TGFb (zeige TGFB1 Antikörper) signaling in advanced HNSCC patients with PIK3CA (zeige PIK3CA Antikörper) amplification
miR (zeige MLXIP Antikörper)-379 could function as a tumour-suppressing miRNA via targeting PDK1 in osteosarcoma.
These results also suggest that inhibition of HIF-1a (zeige HIF1A Antikörper) with 2-MeOE2 sensitizes radioresistant melanoma cells 435R to X-ray irradiation through targeting the glycolysis that is regulated by PDK1
PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker.
A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.
Our results demonstrated that down-regulation of SDHB (zeige SDHB Antikörper) and up-regulation of PDK1 may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in recurrent nasopharyngeal carcinoma patients
n the conditon of miR (zeige MLXIP Antikörper)- 128b over-expression, we also observed spontaneous inactivation of the Akt (zeige AKT1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) signalling, implying PDK1 was a potential regulator of this pathway. In conclusion, our study shed some novel light on miR (zeige MLXIP Antikörper)-128b-PDK1/Akt (zeige AKT1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) axis onGastric cancer (GC) progression
Dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa.
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.
pyruvate dehydrogenase kinase, isoenzyme 1
, pyruvate dehydrogenase kinase, isozyme 1
, pyruvate dehydrogenase [lipoamide] kinase isozyme 1, mitochondrial-like
, PDH kinase 1
, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
, mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1
, PDK p48
, pyruvate dehydrogenase kinase 1