MTOR Proteine (FRAP1)

Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteine (FRAP1)
Auf finden Sie aktuell 4 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MTOR Antikörper (369) und MTOR Kits (45) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 433 MTOR Produkte verfügbar.
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
alle Proteine anzeigen Gen GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

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Am meisten referenzierte MTOR Proteine

  1. Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555 : Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016 (PubMed)

Weitere Proteine zu MTOR Interaktionspartnern

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

  1. High mTOR expression is associated with melanoma.

  2. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (zeige INS Proteine) activates mTORC2 (zeige CRTC2 Proteine) remains poorly defined.

  3. Mutated MTOR identified in central nervous system germ cell tumors upregulated phosphorylation of the AKT (zeige AKT1 Proteine) pathway proteins

  4. Findings demonstrate that the Akt (zeige AKT1 Proteine)/mTOR pathway is upregulated in verrucous carcinoma of the oral cavity , indicating a role for this pathway in the development and progression of this malignancy.

  5. IL-37 regulates autophagy in SMMC-7721 and Huh-7 cells via inhibition of the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/mTOR signaling pathway.

  6. A nutrient-sensitive mTOR/ChREBP (zeige MLXIPL Proteine) regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes.

  7. Interleukin-37 induces apoptosis and autophagy of SMMC-7721 cells by inhibiting phosphorylation of mTOR.

  8. Abnormal mTOR activity may contribute to chemotherapy resistance, while it may also be effectively targeted via molecular means and/or development of specific pharmacological inhibitors.

  9. CXCR2 (zeige CXCR2 Proteine) preferentially supports the maintenance of human pluripotent stem cell characteristics as well as facilitates ectodermal differentiation after the commitment to differentiation, and the mechanism might be associated with mTOR, beta-catenin (zeige CTNNB1 Proteine), and hTERT activities.

  10. Data show that mTOR protein forms a complex with Raptor (zeige RPTOR Proteine) and estrogen receptor-alpha (ERalpha (zeige ESR1 Proteine)).

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

  1. results establish a novel mechanism by which mTORC1 regulates Th1 differentiation, through control of T-bet phosphorylation

  2. Tsc2-mTOR signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.

  3. This study suggests that mTOR activity in hepatocytes decreases hepatic vulnerability to injury through a mechanism dependent on NF-kappaB (zeige NFKB1 Proteine) proinflammatory cytokine signaling pathway in both normal and steatotic liver.

  4. TSC1 (zeige TSC1 Proteine)/TSC2 complex upregulation of OPN (zeige SPP1 Proteine) expression is mediated by transcription factor SOX9 (zeige SOX9 Proteine) in an mTOR-independent manner. Moreover, ablation of OPN (zeige SPP1 Proteine) by deficient TSC1 (zeige TSC1 Proteine)/TSC2 complex contributed to inactivation of AKT (zeige AKT1 Proteine) in TSC (zeige SLC12A3 Proteine) cells

  5. Suppressing mTOR signaling in in vitro-expanded Vgamma4 gammadelta T cells via the mechanistic inhibitor rapamycin enhanced their cytotoxicity against multiple tumor cell lines, and these cells performed better tumor-suppressing effects upon adoptive therapy. mTOR signaling plays an important role in the cytotoxic effector function of gammadelta T cells.

  6. A nutrient-sensitive mTOR/ChREBP (zeige MLXIPL Proteine) regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes.

  7. Mycobacterium ulcerans mycolactone acts as an inhibitor of the mechanistic Target of Rapamycin (mTOR) signaling pathway by interfering with the assembly of the two distinct mTOR protein complexes mTORC1 and mTORC2 (zeige CRTC2 Proteine)

  8. High mTOR expression is associated with pituitary tumor development.

  9. mTOR protein signaling promotes stable epidermal adhesion in the skin and accelerates wound healing.

  10. mTOR-sensitive perturbation of smooth muscle cell mechanosensing contributes to elastin (zeige ELN Proteine) aortopathy.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

  1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (zeige ESCO2 Proteine) cells and supports that normal gene expression and translation requires ESCO2 (zeige ESCO2 Proteine) function.

  2. By inhibiting mTOR signaling via Fbxw7 (zeige FBXW7 Proteine), the amount of myelination during development is reduced.

  3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (zeige TP53 Proteine).

  5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

  1. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.

  2. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

  3. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

  4. AMPK (zeige PRKAA1 Proteine)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  5. Uroguanylin (zeige GUCA2B Proteine) modulates (Na++K+)ATPase (zeige ATP1A1 Proteine) in a proximal tubule cells via cGMP/protein kinase (zeige CDK7 Proteine) G, cAMP/protein kinase A, and mTOR pathways.

  6. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (zeige CCND1 Proteine), and CCNE1 (zeige CCNE1 Proteine).

  7. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  8. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (zeige RPS6 Proteine)-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.

  9. Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR, Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.

  10. Biochemical, cellular, and molecular data suggest that L-arginine (zeige GATM Proteine) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Interaktionspartner

  1. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

  2. 14-3-3gamma (zeige YWHAG Proteine) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (zeige JAK2 Proteine)-STAT5 (zeige STAT5A Proteine) and mTOR signaling pathways.

  4. Insulin (zeige INS Proteine)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  5. IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor (zeige IGF1R Proteine) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Proteine) level in nonstimulated cells.

  6. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (zeige INS Proteine), and prolactin (zeige PRL Proteine) were associated with increased phosphorylation of the mTOR substrates

  7. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine) signaling in an AKT (zeige AKT1 Proteine)-independent manner

  9. mTOR links IGF-I (zeige IGF1 Proteine) and EGF (zeige EGF Proteine) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik Protein
  • AI327068 Protein
  • flat Protein
  • FRAP Protein
  • frap1 Protein
  • FRAP2 Protein
  • RAFT1 Protein
  • RAPT1 Protein
  • tor Protein
  • wu:fc22h08 Protein

Bezeichner auf Proteinebene für FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
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