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Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
Hydrogen sulfide (zeige SQRDL Proteine) influences multiple biological functions of HCC (zeige FAM126A Proteine) cells through inhibiting the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/mTOR signaling pathway.
Results show that expression level of mTOR and BCL2 (zeige BCL2 Proteine) are regulated by miR497 and provide evidence for their role in the development of TMZ-resistance phenotype of glioma cells.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (zeige INS Proteine) activates mTORC2 (zeige CRTC2 Proteine) remains poorly defined.
activation of MTOR in the epithelium promotes LPS (zeige IRF6 Proteine)-induced acute lung injury.
Authors identified active mTOR as a novel inducer of NED, and elucidated a mechanism underlying the malignant transformation of NEPCa by recapitulating NED in vitro.
PKN (zeige PKN1 Proteine) kinase activity was measured by incorporation of (32) P into protein substrates. Phosphorylation of the turn-motif (TM) in PKN (zeige PKN1 Proteine) proteins by mTOR was analyzed using the TORC2 (zeige CRTC2 Proteine)-specific inhibitor torin (zeige PRDX2 Proteine) and a PKN1 (zeige PKN1 Proteine) phospho-TM-specific antibody.
Data suggest that high expression of phosphorylated mTOR (p-mTORS2448) and YAP1 (zeige YAP1 Proteine) correlates with poor prognosis of glioma patients; potential interaction between mTOR and YAP1 (zeige YAP1 Proteine) signaling pathways may participate in development/progression of gliomas. (mTOR = rapamycin and FKBP12 target 1 protein; YAP1 (zeige YAP1 Proteine) = Yes-associated protein 1 (zeige YAP1 Proteine))
IL-1beta (zeige IL1B Proteine) induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT (zeige AKT1 Proteine)/mTOR/P70S6K (zeige RPS6KB1 Proteine) signaling pathway in human osteoarthritis chondrocytes.
High mTOR expression is associated with Lung cancer.
Inhibits CD25 (zeige IL2RA Proteine) translation through regulation of the LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine)-mTOR pathway to suppress T cells.
MDSCs ameliorated AKI and the protective effect was enhanced by mTOR signal inhibition.
The involvement of mTOR-PGC-1alpha pathway in the connection between FTO (zeige FTO Proteine) and muscle differentiation is displayed.
Taken together, the above results clearly demonstrated an mTORC2 (zeige CRTC2 Proteine)-dependent regulation of actin polymerization that contributed to the effects of ERalpha (zeige ESR1 Proteine) and ERbeta (zeige ESR2 Proteine) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
activation of MTOR in the epithelium promotes LPS (zeige TLR4 Proteine)-induced acute lung injury.
results demonstrated that Rictor/mTORC2 (zeige CRTC2 Proteine) might play an important role in the cardiomyocyte differentiation of mES (zeige PTCH1 Proteine) cells.
Chemerin (zeige RARRES2 Proteine)-CMKLR1 (zeige CMKLR1 Proteine) activates Akt (zeige AKT1 Proteine)/mTOR and ERK (zeige EPHB2 Proteine) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (zeige MEOX2 Proteine) weakens the effect of chemerin (zeige RARRES2 Proteine) on preadipocyte biofunctions.
exploration of the role of AMPK (zeige PRKAA1 Proteine) in lipopolysaccharide (LPS (zeige TLR4 Proteine))-induced myocardial dysfunction and elucidated the potential mechanisms of AMPK (zeige PRKAA1 Proteine)/mTOR pathway regulating autophagy in young and aged mice
ENPP2 (zeige ENPP2 Proteine) links Activin-A (zeige INHBA Proteine) enhanced mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Together, these results indicate that Mtor expression in Sertoli cells is required for the maintenance of spermatogenesis and the progression of germ cell development through the pachytene spermatocyte stage. One mechanism of mTOR action may be to regulate gap junction dynamics by inhibiting AKT (zeige AKT1 Proteine), thereby decreasing GJA1 (zeige GJA1 Proteine) phosphorylation and internalization.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (zeige ESCO2 Proteine) cells and supports that normal gene expression and translation requires ESCO2 (zeige ESCO2 Proteine) function.
By inhibiting mTOR signaling via Fbxw7 (zeige FBXW7 Proteine), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (zeige TP53 Proteine).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (zeige PRKAA1 Proteine)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (zeige GUCA2B Proteine) modulates (Na++K+)ATPase (zeige ATP1A1 Proteine) in a proximal tubule cells via cGMP/protein kinase (zeige CDK7 Proteine) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (zeige CCND1 Proteine), and CCNE1 (zeige CCNE1 Proteine).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (zeige RPS6 Proteine)-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR, Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (zeige GATM Proteine) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (zeige YWHAG Proteine) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (zeige JAK2 Proteine)-STAT5 (zeige STAT5A Proteine) and mTOR signaling pathways.
Insulin (zeige INS Proteine)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor (zeige IGF1R Proteine) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Proteine) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (zeige INS Proteine), and prolactin (zeige PRL Proteine) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine) signaling in an AKT (zeige AKT1 Proteine)-independent manner
mTOR links IGF-I (zeige IGF1 Proteine) and EGF (zeige EGF Proteine) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin