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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
Results suggest that the TCF (zeige HNF4A Proteine)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (zeige CCNDBP1 Proteine) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (zeige SMC1A Proteine) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (zeige MEIS1 Proteine) regulating cyclin D1 and c-myc (zeige MYC Proteine) transcription in the embryonic eye.
Data suggest that subcellular localization of cyclin D1 (Ccnd1) is an interesting guideline to measure cancer outcome.
MEK2 (zeige MAP2K2 Proteine) was essential for the phosphorylation of MKK3 (zeige MAP2K3 Proteine)/MKK6 (zeige MAP2K6 Proteine) and p38 MAPK (zeige MAPK14 Proteine) that directly impacted on cyclin D1 expression.
miR (zeige MLXIP Proteine)-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2 (zeige KDM5A Proteine)/NOTCH1 (zeige NOTCH1 Proteine)/CYCLIN D1 coregulatory network.
Findings indicate cyclin D1 (CCND1) as a target of microRNA miR (zeige MLXIP Proteine)-1296.
High CCND1 expression is associated with Myelodysplastic syndromes.
Correlating beta-catenin (zeige CTNNB1 Proteine) nuclear dynamics to cyclin D1 transcriptional activation showed that the nuclear accumulation rate of change of the signaling factor, and not actual protein levels, correlated with the transcriptional output of the pathway.
Taken together, these findings enabled us to identify a novel mechanism by which eEF1A1 (zeige EEF1A1 Proteine) regulates the cell cycle's G1 phase to promote tumor proliferation by regulating cyclin D1 expression through STAT1 (zeige STAT1 Proteine) signaling in HCC (zeige FAM126A Proteine).
This meta-analysis suggests that the CCND1 G870A polymorphism is associated with an increased risk of colorectal cancer, especially that A carriers may be a major risk factor for colorectal cancer.
results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. Treatment with fascaplysin also suppressed CDK4 (zeige CDK4 Proteine), cyclin D1, Bcl-2 (zeige BCL2 Proteine), and VEGFA (zeige VEGFA Proteine) expression at protein levels
Mutation in the CCND1 gene is associated with acute myeloid leukemia (zeige BCL11A Proteine).
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (zeige CSF1R Proteine)/c-Fms (zeige CSF1R Proteine)-mediated downstream signaling pathways like activation of ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (zeige CTNNB1 Proteine)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (zeige PAX5 Proteine) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), Klf4 (zeige KLF4 Proteine), and c-Myc (zeige MYC Proteine) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (zeige PLCG1 Proteine) controls osteoclast numbers via a CSF-1 (zeige CSF1 Proteine)-dependent DAG/beta-catenin (zeige CTNNB1 Proteine)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Proteine), Cyc (zeige CYCS Proteine)-D1 and TERT (zeige TERT Proteine), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (zeige DND1 Proteine) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (zeige IL33 Proteine).
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (zeige CDK2 Proteine) and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (zeige MAPK3 Proteine) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, Cyclin-D1-binding protein 1 homolog
, cyclin Dx
, cyclin-D1-binding protein 1 homolog
, zebrafish homolog of Maid
, cyclin D1
, G1/S-specific cyclin-D1
, B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, PRAD1 oncogene
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)