Cyclin D1 Proteine (CCND1)

Auf finden Sie aktuell 27 Cyclin D1 (CCND1) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Cyclin D1 Antikörper (554) und Cyclin D1 Kits (57) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 665 Cyclin D1 Produkte verfügbar.
AI327039, bcl-1, BCL1, cb161, CCND1, ccnd1a, ccnd1b, ccndbp1, cD1, cycd1, Cyl-1, D11S287E, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, PRAD1, U21B31, wu:fb52e01, wu:fc45c08, wu:fc83a12, ZHM
alle Proteine anzeigen Gen GeneID UniProt
CCND1 595 P24385
CCND1 12443 P25322
CCND1 58919 P39948

Cyclin D1 Proteine (CCND1) nach Spezies

Weitere Proteine zu Cyclin D1 Interaktionspartnern

Xenopus laevis Cyclin D1 (CCND1) Interaktionspartner

  1. Results suggest that the TCF (zeige HNF4A Proteine)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.

Zebrafish Cyclin D1 (CCND1) Interaktionspartner

  1. while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of

  2. Maid (zeige CCNDBP1 Proteine) is important regulator of hepatocarcinogenesis and aging

  3. show that the knockdown of smc1a (zeige SMC1A Proteine) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

  4. Reduction of cyclin D1 expression compromises zebrafish eye and head development.

  5. Role in cell cycle control is mediated by meis1 (zeige MEIS1 Proteine) regulating cyclin D1 and c-myc (zeige MYC Proteine) transcription in the embryonic eye.

Human Cyclin D1 (CCND1) Interaktionspartner

  1. Describe a regulatory loop miR (zeige MLXIP Proteine)-218-CDK6 (zeige CDK6 Proteine)/CyclinD1-E2F1 (zeige E2F1 Proteine) whose disruption may contribute to cell cycle progression in gastric cancer.

  2. EGF induces hair follicle-derived mesenchymal stem cell proliferation through the EGFR/ERK and AKT pathways, but not through STAT-3. The G1/S transition was stimulated by upregulation of cyclinD1 and inhibition of p16 expression.

  3. Case Report: in the absence of the typical CCND1/IGH@ fusion, t(11;12)(q13;p11.2) promotes Mantle cell lymphoma pathogenesis by eliminating miRNA interaction elements within the 3'-UTR of the CCND1 mRNA transcript consequently resulting in CCND1 overexpression.

  4. The CCND1 genes were found very close to the IGH locus in naive B cells and further away after maturation. In contrast, the CMYC alleles became localized closer to an IGH locus at the stage of SHM/CSR.

  5. Consistently, samples from oral squamous cell carcinoma (OSCC) patients exhibited a noticeably stronger CREPT (zeige RPRD1B Proteine) expression than noncancerous samples. In contrast, knocking down of CREPT (zeige RPRD1B Proteine) in OSCC cell lines significantly reduced proliferation, colony formation and migration as well as the expression of cyclin D1 and c-Myc (zeige MYC Proteine), but promoted apoptosis.

  6. Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.

  7. cyclin D1 and other cyclins such as cyclin A (zeige CCNA2 Proteine) regulates DNA integrity through RAD51 (zeige RAD51 Proteine) interaction with the BRCA2 (zeige BRCA2 Proteine) C-terminal domain

  8. gankyrin (zeige PSMD10 Proteine) regulates HIF-1alpha (zeige HIF1A Proteine) protein stability and cyclin D1 expression, ultimately mediating FSH (zeige BRD2 Proteine)-driven ovarian cancer cell proliferation

  9. Cyclin D1 can be exploitable as a diagnostic adjunct to conventional markers in confirming the diagnosis of Esing sarcoma/peripheral primitive neuroectodermal tumors or neuroblastoma (zeige ARHGEF16 Proteine)/ganglioneuroblastoma.

  10. ZNF322A (zeige ZNF322A Proteine) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis

Mouse (Murine) Cyclin D1 (CCND1) Interaktionspartner

  1. Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.

  2. our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (zeige CTNNB1 Proteine)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.

  3. identify Pax5 (zeige PAX5 Proteine) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.

  4. Data show that expression of the Oct-4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), Klf4 (zeige KLF4 Proteine), and c-Myc (zeige MYC Proteine) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.

  5. study shows that PLCgamma1 (zeige PLCG1 Proteine) controls osteoclast numbers via a CSF-1 (zeige CSF1 Proteine)-dependent DAG/beta-catenin (zeige CTNNB1 Proteine)/cyclinD1 pathway.

  6. Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Proteine), Cyc (zeige CYCS Proteine)-D1 and TERT (zeige TERT Proteine), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.

  7. Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (zeige DND1 Proteine) susceptible mice without being necessary for normal germ cell or testis development.

  8. Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (zeige IL33 Proteine).

  9. Novel RNA-binding activity of MYF5 (zeige MYF5 Proteine) enhances Ccnd1 mRNA translation during myogenesis.

  10. The robust increase in the expression of cyclin D1 and CDK4 (zeige CDK4 Proteine) at day 2 suggests that Muller glia may be in G1 phase of the cell cycle at this stage.

Cow (Bovine) Cyclin D1 (CCND1) Interaktionspartner

  1. cyclin D1, CDK2 (zeige CDK2 Proteine) and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

  2. 17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (zeige MAPK3 Proteine) kinase) pathway.

Cyclin D1 (CCND1) Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Alternative names and synonyms associated with Cyclin D1 (CCND1)

  • cyclin D1 (ccnd1-b)
  • cyclin D1 (ccnd1)
  • Cyclin-D1-binding protein 1 homolog (ccndbp1)
  • cyclin Dx (ccndx)
  • zgc:162082 (zgc:162082)
  • cyclin D1 (CCND1)
  • G1/S-specific cyclin-D1 (ccnd1)
  • cyclin D1 (Ccnd1)
  • cyclin D1 (ccnd1-a)
  • AI327039 Protein
  • bcl-1 Protein
  • BCL1 Protein
  • cb161 Protein
  • CCND1 Protein
  • ccnd1a Protein
  • ccnd1b Protein
  • ccndbp1 Protein
  • cD1 Protein
  • cycd1 Protein
  • Cyl-1 Protein
  • D11S287E Protein
  • etID37810.7 Protein
  • fb52e01 Protein
  • fc45c08 Protein
  • fc83a12 Protein
  • id:ibd1198 Protein
  • PRAD1 Protein
  • U21B31 Protein
  • wu:fb52e01 Protein
  • wu:fc45c08 Protein
  • wu:fc83a12 Protein
  • ZHM Protein

Bezeichner auf Proteinebene für Cyclin D1 Proteine (CCND1)

G1/S-specific cyclin-D1 b , cyclin D1 b , parathyroid adenomatosis 1 , cyclin D1 (PRAD1: parathyroid adenomatosis 1) , Cyclin-D1-binding protein 1 homolog , cyclin Dx , cyclin-D1-binding protein 1 homolog , zebrafish homolog of Maid , cyclin D1 , G1/S-specific cyclin-D1 , B-cell CLL/lymphoma 1 , B-cell lymphoma 1 protein , BCL-1 oncogene , PRAD1 oncogene , G1/S-specific cyclin-D1 a , cyclin D1 a (PRAD1: parathyroid adenomatosis 1)

379161 Xenopus laevis
448045 Xenopus (Silurana) tropicalis
495493 Xenopus laevis
548862 Xenopus (Silurana) tropicalis
553373 Danio rerio
574320 Macaca mulatta
747688 Pan troglodytes
100037407 Felis catus
100306852 Salmo salar
595 Homo sapiens
449028 Canis lupus familiaris
100009036 Oryctolagus cuniculus
12443 Mus musculus
58919 Rattus norvegicus
100729808 Cavia porcellus
100171625 Pongo abelii
379937 Xenopus laevis
396341 Gallus gallus
524530 Bos taurus
30222 Danio rerio
100144763 Ovis aries
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