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anti-Human AKT Antikörper:
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Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN361978
Kim, Lee, Kim, Bahk: A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. in Proteomics 2008
Show all 21 Pubmed References
Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN362584
Bahk, Cho, Kim: A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts. in Biochemical and biophysical research communications 2008
Show all 15 Pubmed References
Human Polyclonal AKT Primary Antibody für CyTOF, FACS - ABIN4900619
Wang, Yue, Kim, Fu, Khuri, Sun: Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. in Cancer research 2008
Show all 12 Pubmed References
Human Monoclonal AKT Primary Antibody für IHC, IHC (p) - ABIN252685
Luty, Rodeberg, Parness, Vyas: Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Monoclonal AKT Primary Antibody für ICS - ABIN1177030
Prinz, Mendler, Masouris, Durner, Oberneder, Noessner: High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 7 Pubmed References
Human Polyclonal AKT Primary Antibody für IF, IHC - ABIN361980
Tremblay, Krebs, Dombrowski, Brehm, Bernroider, Roth, Nowotny, Waldhäusl, Marette, Roden: Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. in Diabetes 2005
Show all 10 Pubmed References
Human Polyclonal AKT Primary Antibody für IP, WB - ABIN223018
Artwohl, Muth, Kosulin, de Martin, Hölzenbein, Rainer, Freudenthaler, Huttary, Schmetterer, Waldhäusl, Baumgartner-Parzer: R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. in American journal of physiology. Endocrinology and metabolism 2007
Show all 6 Pubmed References
Human Monoclonal AKT Primary Antibody für WB - ABIN4279016
Nair, Shishodia, Ahn, Kunnumakkara, Sethi, Aggarwal: Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 6 Pubmed References
Human Polyclonal AKT Primary Antibody für IHC, WB - ABIN362586
Xu, Stippec, Lazrak, Huang, Cobb: WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. in The Journal of biological chemistry 2005
Show all 9 Pubmed References
Human Monoclonal AKT Primary Antibody für ICS, WB - ABIN967668
Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997
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The metabolic defects of cycG (zeige CCNG1 Antikörper) mutant animals are abrogated by a concomitant loss of Wdb, CycG (zeige CCNG1 Antikörper) presumably influences Akt1 activity at the PP2A (zeige PPP2R2B Antikörper) nexus; Well rounded (Wrd), another B' subunit of PP2A (zeige PPP2R2B Antikörper) in Drosophila, binds CycG (zeige CCNG1 Antikörper) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (zeige CCNG1 Antikörper) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 Antikörper)-G2019S neurite degeneration by augmenting Akt/NRF2 (zeige NFE2L2 Antikörper) pathway and inhibiting downstream GSK3b (zeige GSK3b Antikörper) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 Antikörper)-G2019S parkinsonism.
subtle manipulation of foxo (zeige FOXO Antikörper) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 Antikörper) localization, and postsynaptic membrane elaboration
Tsc2 (zeige TSC2 Antikörper) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 Antikörper) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 Antikörper) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten (zeige PTEN Antikörper) and microRNA bantam.
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA Antikörper), which further represses the activity of K(+) channel (zeige KCNC4 Antikörper) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (zeige CBL Antikörper)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 Antikörper)+)-dependent manner, connecting the Ca(2 (zeige CA2 Antikörper)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 Antikörper).
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (zeige GSK3b Antikörper)(Ser9) and Akt(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta (zeige GSK3b Antikörper) signaling axis at cilia in SHH (zeige SHH Antikörper)-dependent medulloblastoma that is regulated by INPP5E (zeige INPP5E Antikörper) to maintain tumor cell cilia, promote SHH (zeige SHH Antikörper) signaling and thereby medulloblastoma progression.
mTORC2 (zeige CRTC2 Antikörper) complex is responsible for phosphorylating Akt at S(473).
FHL2 (zeige FHL2 Antikörper) facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription.
Omentin (zeige ITLN1 Antikörper) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoti (zeige NOS3 Antikörper)ng endothelial barrier via an Akt/NOS3-dependent mechanism.
AIM2 (zeige AIM2 Antikörper) contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (zeige ICAM1 Antikörper) resulted in activation of Akt and beta-catenin (zeige CTNNB1 Antikörper) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (zeige INS Antikörper) dependent Akt phosphorylation and subsequently activates FoxO1 (zeige FOXO1 Antikörper) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (zeige PEPCK Antikörper) and G6pase (zeige G6PC Antikörper). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt in heart.
High Akt1 expression is associated with hepatocarcinogenesis.
ILT3 (zeige LILRB4 Antikörper) may functionally contribute to a regulatory network controlling tumor progression by suppressing the Akt pathway.
Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC (zeige ODC1 Antikörper) and SSAT (zeige SAT1 Antikörper) expression, and the Akt1-mediated pathway.
The impact of AKT1 on glucocorticoid receptor (GR (zeige NR3C1 Antikörper))-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (zeige YWHAQ Antikörper), was examined.
These findings identify phospho-AKT in the primary tumor and miR (zeige MLXIP Antikörper)-200c later during tumor progression as prognostic molecules.
This study showed that the induction level of IL-32 (zeige IL32 Antikörper) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (zeige IRF6 Antikörper)-induced IL-32 (zeige IL32 Antikörper) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (zeige TLR4 Antikörper)/JNK (zeige MAPK8 Antikörper)/AKT/CREB (zeige CREB1 Antikörper) signaling pathway.
Phosphorylation of MITF (zeige MITF Antikörper) by AKT affects its downstream targets and causes TP53 (zeige TP53 Antikörper)-dependent cell senescence
IL-1beta (zeige IL1B Antikörper) induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT/mTOR (zeige FRAP1 Antikörper)/P70S6K (zeige RPS6KB1 Antikörper) signaling pathway in human osteoarthritis chondrocytes.
KRAS mutations and AKT activation are present in Wilms tumors (WT) and may represent novel therapeutic targets for this tumor.
High AKT1 expression is associated with Lung cancer.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) signaling and suppressing the activation of TLR4 (zeige TLR4 Antikörper) and/or NOD2 (zeige NOD2 Antikörper) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (zeige LRP2 Antikörper) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB Antikörper); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 Antikörper) accumulation and subsequent ovarian E2 production.
Caveolin-1 (zeige CAV1 Antikörper) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (zeige TGM2 Antikörper) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b Antikörper), and NF-kappaB (zeige NFKB1 Antikörper).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 Antikörper), reactive oxygen species, and PI3-kinase (zeige PIK3CA Antikörper) in stimulated NO release.
PI3K/Akt and p53 (zeige TP53 Antikörper) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 Antikörper), p70S6K (zeige RPS6KB1 Antikörper), and ERK1/2 (zeige MAPK1/3 Antikörper).
Gab1 (zeige GAB1 Antikörper) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation in endothelial cells
Losartan metabolite stimulates eNOS (zeige NOS3 Antikörper) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF Antikörper)-induced endothelial cell apoptosis by activating AKT1.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1