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anti-AKT (AKT1) Antikörper

Bezeichnung:
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 Antikörper (AKT1)
Auf www.antikoerper-online.de finden Sie aktuell 1159 V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Antikörper von 44 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen AKT Kits (56) und AKT Proteine (46) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1360 AKT Produkte verfügbar.
Synonyme:
akt, akt-1, Akt/PKB, akt1, ATAKT1, CG4006, CWS6, D-Akt, dakt, dAKT/dPKB, dAkt/PKB, dakt1, DAKT1/PKB, Dmel\\CG4006, dPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, F18A8.2, F18A8_2, K+ transporter 1, l(3)04226, l(3)89Bq, p-Akt, pAkt, PKB, PKB-ALPHA, PKB/Akt, PKB/dAKT, PKBalpha, POTASSIUM TRANSPORTER, PRKBA, Rac, RAC-ALPHA, RacPK, v-akt, v-akt1, xAct

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Am meisten referenzierte anti-AKT Antikörper

  1. Human Polyclonal AKT Primary Antibody für FACS, WB - ABIN652283 : Liao, Grobholz, Abel, Trojan, Michel, Angel, Mayer: Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Zeige alle 4 Referenzen für ABIN652283

  2. Human Monoclonal AKT Primary Antibody für EIA, IF - ABIN400786 : Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Zeige alle 4 Referenzen für ABIN400786

  3. Chimpanzee Monoclonal AKT Primary Antibody für EIA, IF - ABIN400784 : Staal: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. in Proceedings of the National Academy of Sciences of the United States of America 1987 (PubMed)
    Zeige alle 4 Referenzen für ABIN400784

  4. Human Polyclonal AKT Primary Antibody für IF (p), IHC (p) - ABIN725195 : Xu, Huang, Xie, Lin, Guo, Zhuang, Lin, Zhou, Li, Huang, Wei, Man, Zhang: The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. in BMC cancer 2013 (PubMed)
    Zeige alle 3 Referenzen für ABIN725195

  5. Chicken Polyclonal AKT Primary Antibody für EIA, IHC (fro) - ABIN117897 : Lawlor, Alessi: PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? in Journal of cell science 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN117897

  6. Human Polyclonal AKT Primary Antibody für DB, IF - ABIN650880 : Chen, Gomes, Monteiro, Wong, Wu, Ng, Karadedou, Millour, Ip, Cheung, Sunters, Chan, Lam, Khoo: Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. in PLoS ONE 2010 (PubMed)

Weitere Antikörper gegen AKT Interaktionspartner

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. subtle manipulation of foxo (zeige FOXO Antikörper) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

  2. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

  3. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

  4. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

  5. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (zeige GRIN1 Antikörper) localization, and postsynaptic membrane elaboration

  6. Tsc2 (zeige TSC2 Antikörper) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (zeige TSC2 Antikörper) mutants, leading to the hypothesis that Tsc2 (zeige TSC2 Antikörper) and Akt might work via the same genetic pathway to regulate synapse growth.

  7. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

  8. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten (zeige PTEN Antikörper) and microRNA bantam.

  9. Overexpression of Akt enhanced Sindbis virus replication.

  10. Perturbation of the Akt/Gsk3-beta (zeige GSK3b Antikörper) signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.

  2. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (zeige FNTA Antikörper), which further represses the activity of K(+) channel (zeige KCNC4 Antikörper) AKT1 in Arabidopsis.

  3. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

  4. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

  5. These findings provide further insights into the signaling network consisting of CBL (zeige CBL Antikörper)-CIPK-PP2C interactions in the activation of the AKT1 channel.

  6. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

  7. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

  8. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

  9. CIPK23 directly phosphorylates the K+ transporter AKT1

  10. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (zeige CA2 Antikörper)+)-dependent manner, connecting the Ca(2 (zeige CA2 Antikörper)+) signal to K(+) uptake through activation of a K(+) channel (zeige KCNC4 Antikörper).

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atroph

  2. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  3. Data show that Akt/mTOR (zeige FRAP1 Antikörper) and MAPK (zeige MAPK1 Antikörper) pathways were activated in ovine pulmonary adenocarcinoma (OPA) lung and envelope (Env (zeige ERVW-1 Antikörper)) of Jaagsiekte sheep retrovirus (JSRV) transfected NIH 3T3 cells.

  4. Results suggest that SC79 compound activates Akt-Nrf2 (zeige NFE2L2 Antikörper) signaling to protect osteoblasts from dexamethasone (Dex).

  5. In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Antikörper)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (zeige IRS1 Antikörper)/PDPK1 (zeige PDPK1 Antikörper)/AKT insulin (zeige INS Antikörper) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Antikörper) and activating PDPK1 (zeige PDPK1 Antikörper). This research may provide new insights into GTPase (zeige RACGAP1 Antikörper)-mediated insulin (zeige INS Antikörper) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Antikörper) sensitizati

  6. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases.

  7. Menin (zeige MEN1 Antikörper) binds on the promoter of Inhbb (zeige INHBB Antikörper) gene where it favours the recruitment of Ezh2 (zeige EZH2 Antikörper) via an indirect mechanism involving Akt-phosphorylation.

  8. A role of AKT in the regulatory T cell differentiation process. TGF-beta (zeige TGFB1 Antikörper) induces the phosphorylation of Akt in CD4 (zeige CD4 Antikörper)+ T cells.

  9. 4-PBA reverses autophagic dysfunction and improves insulin (zeige INS Antikörper) sensitivity in adipose tissue of obese mice via Akt/mTOR (zeige FRAP1 Antikörper) signaling partly, which could be regarded as novel opportunities for treatment of insulin (zeige INS Antikörper) resistance.

  10. These studies reveal a novel mechanism in which CYP2J2 (zeige CYP2J2 Antikörper) and epoxyeicosatrienoic acids enhanced Akt1 nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (zeige PIK3CA Antikörper)-Akt/PKB cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  2. Binding of PP2A (zeige PPP2R4 Antikörper) and Akt increased in response to cAMP or phosphatidic acid (PA), suggesting that their binding is directly responsible for the inactivation of Akt during decidualization.

  3. Results suggest that polymorphism of AKT1 locus is associated with risk of Parkinson's disease and that the G allele at rs2498799 may decrease the risk of Parkinson's disease in the North-eastern part of Han Chinese female population.

  4. Akt phosphorylates inversin (zeige INVS Antikörper) at amino acids 864-866 that are required not only for Akt interaction, but also for inversin (zeige INVS Antikörper) dimerization.

  5. In vitro study using human endothelial cells showed that prostaglandin E2 (PGE2) significantly increased MMP-2 (zeige MMP2 Antikörper) activity as well as tube formation. Inhibition of COX-2 (zeige COX2 Antikörper) and/or phosphorylated AKT suppressed MMP-2 (zeige MMP2 Antikörper) activity and endothelial tube formation suggesting involvement of PGE2 in regulation of MMP-2 (zeige MMP2 Antikörper) activity during angiogenesis.

  6. p-PTEN (zeige PTEN Antikörper), Akt, p-PDK1 (zeige PDK1 Antikörper), and p-GSK-3beta (zeige GSK3b Antikörper) were significantly downregulated after the knockdown of CK2alpha expression.

  7. the results show that EphA2 (zeige EPHA2 Antikörper) endows invasiveness of glioma stem cells in vivo in cooperation with Akt and regulates glioma stem cell properties

  8. We revealed that activation of the PI3K (zeige PIK3CA Antikörper)/Akt pathway was the main cause of impaired autophagy in ELK3 (zeige ELK3 Antikörper) KD. Our results suggest that targeting ELK3 (zeige ELK3 Antikörper) may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics.

  9. Our results show a miRNA editing activity trend aligning with cellular pathways closely associated to hypoxia, such as the VEGF (zeige VEGFA Antikörper) and PI3K (zeige PIK3CA Antikörper)/Akt pathways, providing important novel insights on this poorly elucidated phenomenon.

  10. CYT (zeige CYGB Antikörper)-Rx20 significantly reduced tumor growth of the implanted esophageal cancer cells accompanied by decreased Ki-67 (zeige MKI67 Antikörper), phospho-AKT, and phospho-STAT3 (zeige STAT3 Antikörper) expression.

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (zeige FRAP1 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) signaling and suppressing the activation of TLR4 (zeige TLR4 Antikörper) and/or NOD2 (zeige NOD2 Antikörper) signaling pathways.

  2. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.

  3. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.

  4. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  5. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  6. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  7. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  8. findings show that megalin (zeige LRP2 Antikörper) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB Antikörper); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

  9. protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  10. Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Interaktionspartner

  1. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 Antikörper) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (zeige CAV1 Antikörper) scaffolding domain residue phenylalanine 92 modulates Akt signaling

  3. TG2 (zeige TGM2 Antikörper) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b Antikörper), and NF-kappaB (zeige NFKB1 Antikörper).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 Antikörper), reactive oxygen species, and PI3-kinase (zeige PIK3CA Antikörper) in stimulated NO release.

  6. PI3K/Akt and p53 (zeige TP53 Antikörper) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (zeige FRAP1 Antikörper), p70S6K (zeige RPS6KB1 Antikörper), and ERK1/2 (zeige MAPK1/3 Antikörper).

  8. Gab1 (zeige GAB1 Antikörper) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (zeige NOS3 Antikörper) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF Antikörper)-induced endothelial cell apoptosis by activating AKT1.

  10. prostaglandin F2alpha phosphorylates TSC2 (zeige TSC2 Antikörper) and activates mTOR (zeige FRAP1 Antikörper) and ribosomal protein S6 (zeige RPS6 Antikörper) kinase (zeige RPS6KB1 Antikörper) signaling in an AKT-independent manner

AKT (AKT1) Antigen-Profil

Beschreibung des Gens

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with AKT (AKT1)

  • v-akt murine thymoma viral oncogene homolog 1 (AKT1) Antikörper
  • v-akt murine thymoma viral oncogene homolog 1 (akt1) Antikörper
  • CG4006 gene product from transcript CG4006-RA (Akt1) Antikörper
  • potassium channel AKT1 (KT1) Antikörper
  • thymoma viral proto-oncogene 1 (Akt1) Antikörper
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) Antikörper
  • akt Antikörper
  • akt-1 Antikörper
  • Akt/PKB Antikörper
  • akt1 Antikörper
  • ATAKT1 Antikörper
  • CG4006 Antikörper
  • CWS6 Antikörper
  • D-Akt Antikörper
  • dakt Antikörper
  • dAKT/dPKB Antikörper
  • dAkt/PKB Antikörper
  • dakt1 Antikörper
  • DAKT1/PKB Antikörper
  • Dmel\\CG4006 Antikörper
  • dPKB Antikörper
  • DRAC-PK Antikörper
  • DRAC-PK66 Antikörper
  • DRAC-PK85 Antikörper
  • F18A8.2 Antikörper
  • F18A8_2 Antikörper
  • K+ transporter 1 Antikörper
  • l(3)04226 Antikörper
  • l(3)89Bq Antikörper
  • p-Akt Antikörper
  • pAkt Antikörper
  • PKB Antikörper
  • PKB-ALPHA Antikörper
  • PKB/Akt Antikörper
  • PKB/dAKT Antikörper
  • PKBalpha Antikörper
  • POTASSIUM TRANSPORTER Antikörper
  • PRKBA Antikörper
  • Rac Antikörper
  • RAC-ALPHA Antikörper
  • RacPK Antikörper
  • v-akt Antikörper
  • v-akt1 Antikörper
  • xAct Antikörper

Bezeichner auf Proteinebene für AKT1

RAC-alpha serine/threonine-protein kinase , protein kinase B , v-akt murine thymoma viral oncogene homolog 1 , Akt kinase , Akt1-PA , Akt1-PB , Akt1-PC , CG4006-PA , CG4006-PB , CG4006-PC , dAkt kinase , related to PKA to PKC protein kinases , related to the A and C kinases , AKT1 kinase , PKB alpha , RAC-PK-alpha , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , proto-oncogene c-Akt , rac protein kinase alpha , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , Akt , protein kinase Akt-1 , protein kinase B, alpha , xAkt , serine/threonine protein kinase , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1

GENE ID SPEZIES
100294652 Ovis aries
697747 Macaca mulatta
740898 Pan troglodytes
100101714 Xenopus (Silurana) tropicalis
100490038 Xenopus (Silurana) tropicalis
41957 Drosophila melanogaster
100556289 Anolis carolinensis
100587109 Nomascus leucogenys
817206 Arabidopsis thaliana
11651 Mus musculus
207 Homo sapiens
24185 Rattus norvegicus
399170 Xenopus laevis
395928 Gallus gallus
490878 Canis lupus familiaris
100126861 Sus scrofa
280991 Bos taurus
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