CHEK2 Proteine (CHEK2)

Checkpoint Kinase 2 Proteine (CHEK2)
Auf finden Sie aktuell 13 Checkpoint Kinase 2 (CHEK2) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CHEK2 Antikörper (483) und CHEK2 Kits (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 534 CHEK2 Produkte verfügbar.
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
alle Proteine anzeigen Gen GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
Ratte CHEK2 CHEK2 114212  

Weitere Synonyme anzeigen

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Am meisten referenzierte CHEK2 Proteine

  1. Mouse (Murine) CHEK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2007792 : Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998 (PubMed)
    Zeige alle 5 Referenzen für 2007792

  2. Human CHEK2 Protein expressed in Wheat germ - ABIN1349305 : Troncale, Barbet, Coulibaly, Henry, He, Barillot, Dubois, Hupé, de Koning: NormaCurve: a SuperCurve-based method that simultaneously quantifies and normalizes reverse phase protein array data. in PLoS ONE 2012 (PubMed)
    Zeige alle 2 Referenzen für 1349305

Weitere Proteine zu CHEK2 Interaktionspartnern

Human Checkpoint Kinase 2 (CHEK2) Interaktionspartner

  1. Results indicate that CHEK2 possesses non-cell-autonomous tumor suppressor functions, and present the Chk2 protein as an important mediator in the functional interplay between breast carcinomas and their stromal fibroblasts through repressing the expression/secretion of SDF-1 (zeige CXCL12 Proteine) and IL-6 (zeige IL6 Proteine).

  2. variants in CHEK2 were associated with moderate risks of breast cancer.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (zeige PALB2 Proteine), CHEK2 and ATM (zeige ATM Proteine)

  4. SIAH2 (zeige SIAH2 Proteine) regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  5. MCM2 (zeige MCM2 Proteine)-MCM6 (zeige MCM6 Proteine) complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  6. On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69).

  7. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (zeige SMC4 Proteine) I and II onto the chromatin even in the presence of an active Cdk1 (zeige CDK1 Proteine).

  8. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  9. K373E mutation of CHK2 in tumorigenesis

  10. Checkpoint kinase 1 (zeige CHEK1 Proteine) and 2 signaling is important for apoptin regulation.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA (zeige PCNA Proteine)- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.

  2. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b (zeige DNMT3B Proteine) and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  3. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  4. TRIP13 (zeige TRIP13 Proteine)-deficient spermatocytes also progress to an H1t (zeige HIST1H1T Proteine)-positive stage if ATM (zeige ATM Proteine) activity is attenuated by hypomorphic mutations in Mre11 (zeige MRE11A Proteine) or Nbs1 (zeige NBN Proteine) or by elimination of the ATM (zeige ATM Proteine)-effector kinase CHK2

  5. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  6. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  7. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  8. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  9. Findings indicate that PIRH2 (zeige RCHY1 Proteine) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  10. Chk2 deficiency in Myc (zeige MYC Proteine) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (zeige PARP1 Proteine) inhibition.

CHEK2 Protein Überblick

Protein Überblick

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CHEK2

  • checkpoint kinase 2 (CHEK2)
  • CHK2 checkpoint homolog (S. pombe) (chek2)
  • checkpoint kinase 2 (Chek2)
  • CHK2 checkpoint homolog (S. pombe) (CHEK2)
  • serine/threonine-protein kinase chk2 (MCYG_07308)
  • blue sensitive cone opsin (LOC396525)
  • Cds1 Protein
  • CHK-2 Protein
  • Chk2 Protein
  • fa66f08 Protein
  • hCds1 Protein
  • HUCDS1 Protein
  • LFS2 Protein
  • PP1425 Protein
  • Rad53 Protein
  • wu:fa66f08 Protein
  • zgc:55865 Protein

Bezeichner auf Proteinebene für Checkpoint Kinase 2 Proteine (CHEK2)

CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , protein kinase CHK2 , checkpoint and tumor suppressor protein 2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2 , CHK2 checkpoint homolog (S. pombe) , serine/threonine-protein kinase Chk2-like , serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2

11200 Homo sapiens
486338 Canis lupus familiaris
458733 Pan troglodytes
100192447 Sus scrofa
336998 Danio rerio
768913 Gallus gallus
50883 Mus musculus
114212 Rattus norvegicus
100059288 Equus caballus
100404949 Callithrix jacchus
100467146 Ailuropoda melanoleuca
100594542 Nomascus leucogenys
9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
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