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Human C-MYC Protein expressed in HEK-293 Cells - ABIN2715370
Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: Sin3b interacts with Myc and decreases Myc levels. in The Journal of biological chemistry 2014
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rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1 (zeige PIAS2 Proteine), to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context.
miR-17-92-dependent tuning of LKB1 (zeige STK11 Proteine) levels regulates both the metabolic potential of Myc+ lymphomas and tumor growth in vivo.
Under diabetic oxidative stress or H2O2 stimulation, nuclear beta-catenin (zeige CTNNB1 Proteine) accumulation upregulated downstream c-Myc and further facilitated DNA damage and p53 (zeige TP53 Proteine)-mediated apoptosis as well as cell viability reduction, followed by phenotypic changes of cardiac dysfunction, interstitial fibrosis deposition and myocardial atrophy.
deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 Proteine)- and NOTCH1 (zeige NOTCH1 Proteine)-regulated genes, including the MYB (zeige MYB Proteine) and MYC oncogenes, respectively.
B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3beta inhibition
High Myc expression is associated with hepatocarcinogenesis.
Myc-high embryonic stem cells (ESCs (zeige NR2E3 Proteine)) approach the naive pluripotency state, whereas Myc-low ESCs (zeige NR2E3 Proteine) are closer to the differentiation-primed state.
Authors here report the first MBG3 model from embryonic cerebellar cells by Myc activation and loss of Trp53 (zeige TP53 Proteine) function using in utero electroporation (EP)-based in vivo gene transfer combined to a Cre/LoxP-mediated technology.
by controlling both nanodomain decompaction and PolII promoter escape Myc stands as a master regulator of transcriptome amplification during B cell activation (zeige BLNK Proteine).
these results indicate that PIAS1 (zeige PIAS1 Proteine) is a positive regulator of MYC.
Apoptosis was also observed with myca expression; introduction of homozygous tp53 (zeige TP53 Proteine)(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.
MYC down-regulation induces mitochondrial apoptosis in T lymphoblasts.
MYC might be the key gene of hypoxia and radiation induced cell death in lung cancer cells.
any of the molecules or processes in the network could be targeted to curb the oncogenic effects of c-Myc, just as BRD4 (zeige BRD4 Proteine) can be targeted. And since the targeting of metabolic enzymes has proved effective in mouse tumor models, it might be possible to develop new therapies based on the fact that c-Myc has a role in controlling cellular metabolism
we evaluated the (-)-JQ1 enantiomer that is structurally incapable of inhibiting BET bromodomains, which resulted in a minimal impact on MYC transcription, but did not result in a statistically significant difference in tumor burden or survival distributions compared to treatment with (+)-JQ1.
our data showed that the depletion of CIP2A (zeige KIAA1524 Proteine) expression in PCa (zeige FLVCR1 Proteine) cell line DU-145 resulted in reduced c-MYC protein levels
the MYU/hnRNP-K (zeige HNRNPK Proteine)/CDK6 (zeige CDK6 Proteine) pathway functions downstream of Wnt/c (zeige WNT7B Proteine)-Myc signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells.
CIP2A (zeige KIAA1524 Proteine) knockdown led to substantial reductions in c-Myc levels in PCa (zeige FLVCR1 Proteine) cell lines, but no significant change in phosphorylated Akt (zeige AKT1 Proteine) expression after CIP2A (zeige KIAA1524 Proteine) knockdown in DU-145 cells.
Data show that MYC, BCL2 (zeige BCL2 Proteine) and BCL6 (zeige BCL6 Proteine) translocation had no prognostic impact with respect to progression free survival (PFS) or overall survival (OS).
Study demonstrated that local recurrent gastric cancer patients showed higher c-Myc and hTERT expression at the protein and mRNA levels, and that acidified bile acids enhance tumor progression and telomerase activity in gastric cancer via Myc activity.
EBNA2 recruits the BRG1 (zeige SMARCA4 Proteine) ATPase of the SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) remodeller to MYC enhancers and BRG1 (zeige SMARCA4 Proteine) is required for enhancer-promoter interactions in Epstein-Barr virus-infected cells.
No significant difference in survival was found between patients with DLBCL with MYC ICN and patients with no MYC aberrations
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
v-myc myelocytomatosis viral oncogene homolog
, Avian myelocytomatosis viral (v-myc) oncogene homolog
, myc proto-oncogene protein
, myelocytomatosis viral oncogene homolog
, proto-oncogene c-Myc
, transcription factor p64
, v-myc avian myelocytomatosis viral oncogene homolog
, c-myc proto-oncogene
, cellular myelocytomatosis oncogene
, transcriptional regulator Myc-A
, avian myelocytomatosis viral oncogene homolog
, class E basic helix-loop-helix protein 39
, myc-related translation/localization regulatory factor
, avian myelocytomatosis viral (v-myc) oncogene homolog
, Proto-oncogene c-Myc
, Transcription factor p64
, Myc proto-oncogene protein