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anti-Rat (Rattus) ATR Antikörper:
anti-Human ATR Antikörper:
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Polyclonal ATR Primary Antibody für IHC (p) - ABIN4948298
Zhou, Lu, Wulf, Lu: Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. in Cellular and molecular life sciences : CMLS 2001
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Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.
PM2.5 exposure strongly induced the activation of the ATR (ATR (zeige ANTXR1 Antikörper) serine/threonine kinase (zeige TLK2 Antikörper))-CHEK1/CHK1 (checkpoint kinase 1 (zeige CHEK1 Antikörper)) axis, which subsequently triggered TP53 (zeige TP53 Antikörper)-dependent autophagy and VEGFA (zeige VEGFA Antikörper) production in Beas-2B cells.
REV3/ATR knockdown enhances the cytotoxicity of cisplatin in non-small cell lung cells.
ATR (zeige ANTXR1 Antikörper) promotes homologous recombination after CDK (zeige CDK4 Antikörper)-driven DNA end resection.
Authors examine how the replication stress response that is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR) senses and resolves threats to DNA integrity so that the DNA remains available to read in all of our cells. They discuss the multiple data that have revealed an elegant yet increasingly complex mechanism of ATR activation. [Review]
results reveal a previously unknown role for transcription factor IIH in ATR kinase activation in non-replicating, non-cycling cells
Our data reveal that BETi can potentiate the cell stress and death caused by ATR inhibitors. This suggests that ATRi can be used in combination therapies of lymphomas without the use of genotoxic drugs
Ultraviolet rays-induced ATR (zeige ANTXR1 Antikörper) and ATM (zeige ATM Antikörper) recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.
Small molecule ATR (zeige ANTXR1 Antikörper) and Chk1 (zeige CHEK1 Antikörper) inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response
ATR (zeige ANTXR1 Antikörper) inhibition potentiated Chk1 (zeige CHEK1 Antikörper) inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (zeige ANTXR1 Antikörper)-dependent feedback activation of Chk1 (zeige CHEK1 Antikörper) induced by Chk1 (zeige CHEK1 Antikörper) inhibitor generated replication stress in tumor cell lines.
Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) and Wnt inhibitory factor 1 (zeige WIF1 Antikörper), and a significant increase in cell death after tyrosine kinase (zeige TXK Antikörper) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (zeige TXK Antikörper) inhibitors.
The authors show, in live cells, that Ddx19 (zeige DDX19B Antikörper) transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1 (zeige CHEK1 Antikörper)-dependent manner, and that Ddx19 (zeige DDX19B Antikörper) nuclear relocalization is required to clear R-loops (DNA:RNA hybrids).
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
APE2 (zeige APEX2 Antikörper) associates with Chk1 (zeige CHEK1 Antikörper); a serine residue (S86) in the Chk1 (zeige CHEK1 Antikörper)-binding motif of APE2 (zeige APEX2 Antikörper) is essential for Chk1 (zeige CHEK1 Antikörper) phosphorylation, indicating a Claspin (zeige CLSPN Antikörper)-like but distinct role for APE2 (zeige APEX2 Antikörper) in ATR-Chk1 (zeige CHEK1 Antikörper) signaling.
MRN (MRE11 (zeige MRE11A Antikörper)-RAD50 (zeige RAD50 Antikörper)-NBS1 (zeige NLRP2 Antikörper)) complex has role in ATR activation via TOPBP1 (zeige TOPBP1 Antikörper) recruitment.
ATM (zeige ATM Antikörper) activity is required for an early step in resection, leading to ATR activation, CtIP (zeige RBBP8 Antikörper)-T818 phosphorylation, and accumulation of CtIP (zeige RBBP8 Antikörper) on chromatin.
ATM (zeige ATM Antikörper) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper)/Nbs1 (zeige NLRP2 Antikörper) dependent recovery of collapsed replication forks.
Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.
ATM (zeige ATM Antikörper) and ATR phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Antikörper) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
ATRIP (zeige ATRIP Antikörper) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (zeige CHEK1 Antikörper) effectively
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
DNA damage induces a kinetochore-based ATM/ATR-independent spindle assembly checkpoint arrest.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA (zeige PCNA Antikörper)- and ATM (zeige ATM Antikörper)/ATR-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.
Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced proliferation-associated DNA damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. Genetic deletion of Atr blocked tumorigenesis in medulloblastoma-prone SmoM2 mice.
ATR controls DNA damage-induced G2 checkpoint control and apoptosis in proliferating neurons.
CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.
These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.
RAD9 (zeige RAD9A Antikörper) has a prominent role in the ATR-Chk1 (zeige CHEK1 Antikörper) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
telomeres are protected from hyper-resection through the repression of the ATM (zeige ATM Antikörper) and ATR kinases by TRF2 (zeige TERF2 Antikörper) and TPP1 (zeige TPP1 Antikörper)-bound POT1a (zeige POT1 Antikörper)/b, respectively.
DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair
ATR function together with SOG1 and ALT2 (zeige GPT2 Antikörper) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.
Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.
ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.
findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.
Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.
cooperation among DNA translesion synthesis (TLS (zeige FUS Antikörper)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (zeige ATM Antikörper))
Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.
The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.
Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
ataxia telangiectasia and Rad3 related
, ataxia telangiectasia and Rad3 related protein
, serine/threonine-protein kinase ATR-like
, FRAP-related protein 1
, FRAP-related protein-1
, MEC1, mitosis entry checkpoint 1, homolog
, Rad3 related protein
, ataxia telangiectasia and Rad3-related protein
, protein kinase ATR
, serine/threonine-protein kinase ATR
, checkpoint kinase
, protein kinase
, serine/threonine-protein kinase atr