anti-ATR (ATR) Antikörper

anti-Ataxia Telangiectasia and Rad3 Related Antikörper (ATR)
Auf finden Sie aktuell 11 Ataxia Telangiectasia and Rad3 Related (ATR) Antikörper von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 12 ATR Produkte verfügbar.
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, frp1, mec1, MHK7.5, MHK7_5, sckl, sckl1, si:dkey-231j24.1, XATR
Alle Antikörper anzeigen Gen GeneID UniProt
ATR 300942  
ATR 545 Q13535
ATR 245000  

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anti-Rat (Rattus) ATR Antikörper:

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Am meisten referenzierte anti-ATR Antikörper

  1. Human Polyclonal ATR Primary Antibody für IHC (p) - ABIN319379 : Vostal, Shafer, Mondoro, Fratantoni: Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets. in Biochimica et biophysica acta 1997 (PubMed)
    Zeige alle 4 Referenzen für 319379

  2. Polyclonal ATR Primary Antibody für IHC (p) - ABIN4948298 : Zhou, Lu, Wulf, Lu: Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. in Cellular and molecular life sciences : CMLS 2001 (PubMed)
    Zeige alle 3 Referenzen für 4948298

  3. Human Monoclonal ATR Primary Antibody für WB - ABIN1449281 : Cimprich, Shin, Keith, Schreiber: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

Weitere Antikörper gegen ATR Interaktionspartner

Zebrafish Ataxia Telangiectasia and Rad3 Related (ATR) Interaktionspartner

  1. Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.

Human Ataxia Telangiectasia and Rad3 Related (ATR) Interaktionspartner

  1. Our data reveal that BETi can potentiate the cell stress and death caused by ATR inhibitors. This suggests that ATRi can be used in combination therapies of lymphomas without the use of genotoxic drugs

  2. Ultraviolet rays-induced ATR (zeige ANTXR1 Antikörper) and ATM (zeige ATM Antikörper) recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.

  3. Small molecule ATR (zeige ANTXR1 Antikörper) and Chk1 (zeige CHEK1 Antikörper) inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  4. ATR (zeige ANTXR1 Antikörper) inhibition potentiated Chk1 (zeige CHEK1 Antikörper) inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (zeige ANTXR1 Antikörper)-dependent feedback activation of Chk1 (zeige CHEK1 Antikörper) induced by Chk1 (zeige CHEK1 Antikörper) inhibitor generated replication stress in tumor cell lines.

  5. Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) and Wnt inhibitory factor 1 (zeige WIF1 Antikörper), and a significant increase in cell death after tyrosine kinase (zeige TXK Antikörper) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (zeige TXK Antikörper) inhibitors.

  6. HPV31 regulates RRM2 (zeige RRM2 Antikörper) levels through expression of E7 and activation of the ATR (zeige ANTXR1 Antikörper)-Chk1 (zeige CHEK1 Antikörper)-E2F1 (zeige E2F1 Antikörper) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  7. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  8. that parallel TopBP1- and ETAA1-mediated pathways underlie ATR activation and that their combined action is essential for coping with replication stress

  9. The bocavirus large viral nonstructural protein NS1 (zeige PTPN11 Antikörper) is sufficient to induce the DNA damage response and the activation of the host ATM (zeige ATM Antikörper), ATR (zeige ANTXR1 Antikörper), and DNAPK (zeige PRKDC Antikörper).

  10. It is proposed that ATR functions control cell plasticity by sensing structural deformations of different cellular components, including DNA and initiating appropriate repair responses. (Review)

Xenopus laevis Ataxia Telangiectasia and Rad3 Related (ATR) Interaktionspartner

  1. The authors show, in live cells, that Ddx19 (zeige DDX19B Antikörper) transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1 (zeige CHEK1 Antikörper)-dependent manner, and that Ddx19 (zeige DDX19B Antikörper) nuclear relocalization is required to clear R-loops (DNA:RNA hybrids).

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. APE2 (zeige APEX2 Antikörper) associates with Chk1 (zeige CHEK1 Antikörper); a serine residue (S86) in the Chk1 (zeige CHEK1 Antikörper)-binding motif of APE2 (zeige APEX2 Antikörper) is essential for Chk1 (zeige CHEK1 Antikörper) phosphorylation, indicating a Claspin (zeige CLSPN Antikörper)-like but distinct role for APE2 (zeige APEX2 Antikörper) in ATR-Chk1 (zeige CHEK1 Antikörper) signaling.

  4. MRN (MRE11 (zeige MRE11A Antikörper)-RAD50 (zeige RAD50 Antikörper)-NBS1 (zeige NLRP2 Antikörper)) complex has role in ATR activation via TOPBP1 (zeige TOPBP1 Antikörper) recruitment.

  5. ATM (zeige ATM Antikörper) activity is required for an early step in resection, leading to ATR activation, CtIP (zeige RBBP8 Antikörper)-T818 phosphorylation, and accumulation of CtIP (zeige RBBP8 Antikörper) on chromatin.

  6. ATM (zeige ATM Antikörper) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper)/Nbs1 (zeige NLRP2 Antikörper) dependent recovery of collapsed replication forks.

  7. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.

  8. ATM (zeige ATM Antikörper) and ATR phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Antikörper) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  9. ATRIP (zeige ATRIP Antikörper) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (zeige CHEK1 Antikörper) effectively

  10. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

Mouse (Murine) Ataxia Telangiectasia and Rad3 Related (ATR) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA (zeige PCNA Antikörper)- and ATM (zeige ATM Antikörper)/ATR-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.

  2. Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced proliferation-associated DNA damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. Genetic deletion of Atr blocked tumorigenesis in medulloblastoma-prone SmoM2 mice.

  3. ATR controls DNA damage-induced G2 checkpoint control and apoptosis in proliferating neurons.

  4. CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.

  5. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.

  6. RAD9 (zeige RAD9A Antikörper) has a prominent role in the ATR-Chk1 (zeige CHEK1 Antikörper) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  7. telomeres are protected from hyper-resection through the repression of the ATM (zeige ATM Antikörper) and ATR kinases by TRF2 (zeige TERF2 Antikörper) and TPP1 (zeige TPP1 Antikörper)-bound POT1a (zeige POT1 Antikörper)/b, respectively.

  8. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  9. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair

  10. Observations suggest that ATR mediates a mechanical response to membrane stress that could be caused by chromatin dynamics and is important for genome integrity.

Arabidopsis thaliana Ataxia Telangiectasia and Rad3 Related (ATR) Interaktionspartner

  1. ATR function together with SOG1 and ALT2 (zeige GPT2 Antikörper) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.

  2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.

  3. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.

  4. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  5. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.

  6. Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.

  7. cooperation among DNA translesion synthesis (TLS (zeige FUS Antikörper)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (zeige ATM Antikörper))

  8. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.

  9. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.

  10. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]

ATR Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with ATR

  • ataxia telangiectasia and Rad3 related (Atr) Antikörper
  • ataxia telangiectasia and Rad3 related (ATR) Antikörper
  • ataxia telangiectasia and Rad3 related (atr) Antikörper
  • serine/threonine-protein kinase ATR (ATR) Antikörper
  • ATATR Antikörper
  • Ataxia telangiectasia-mutated and RAD3-related Antikörper
  • ATR Antikörper
  • ATRAD3 Antikörper
  • FCTCS Antikörper
  • frp1 Antikörper
  • mec1 Antikörper
  • MHK7.5 Antikörper
  • MHK7_5 Antikörper
  • sckl Antikörper
  • sckl1 Antikörper
  • si:dkey-231j24.1 Antikörper
  • XATR Antikörper

Bezeichner auf Proteinebene für ATR

ataxia telangiectasia and Rad3 related , ataxia telangiectasia and Rad3 related protein , serine/threonine-protein kinase ATR-like , FRAP-related protein 1 , FRAP-related protein-1 , MEC1, mitosis entry checkpoint 1, homolog , Rad3 related protein , ataxia telangiectasia and Rad3-related protein , protein kinase ATR , serine/threonine-protein kinase ATR , checkpoint kinase , protein kinase , serine/threonine-protein kinase atr

300942 Rattus norvegicus
460745 Pan troglodytes
477101 Canis lupus familiaris
504869 Bos taurus
567770 Danio rerio
714443 Macaca mulatta
100062529 Equus caballus
100127459 Sus scrofa
100412321 Callithrix jacchus
100454403 Pongo abelii
100464897 Ailuropoda melanoleuca
100561948 Anolis carolinensis
545 Homo sapiens
398197 Xenopus laevis
245000 Mus musculus
834082 Arabidopsis thaliana
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