ATM Proteine (ATM)

Bezeichnung:
Ataxia Telangiectasia Mutated Proteine (ATM)
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Synonyme:
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm
alle Proteine anzeigen Gen GeneID UniProt
ATM 472 Q13315
Ratte ATM ATM 300711  
ATM 11920 Q62388

Weitere Synonyme anzeigen

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Weitere Proteine zu ATM Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (zeige TPT1 Proteine) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (zeige MRE11A Proteine) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. Dna2 co-localizes in foci with RPA (zeige RPA1 Proteine) and is found in a complex with replication fork components And-1 and Mcm10 (zeige MCM10 Proteine). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (zeige NLRP2 Proteine) and ATM.

  2. ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Proteine)/Rad50 (zeige RAD50 Proteine)/Nbs1 (zeige NLRP2 Proteine) dependent recovery of collapsed replication forks.

  3. ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Proteine) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (zeige TOPBP1 Proteine) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (zeige TOPBP1 Proteine) with ATR(ATM and Rad3-related).

  6. ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (zeige CEP63 Proteine) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (zeige TOPBP1 Proteine)-dependent activation of ATR-ATRIP (zeige ATRIP Proteine) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (zeige USP14 Proteine) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. We report that endogenous huntingtin (zeige HTT Proteine) protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin (zeige HTT Proteine) in live cells, we show that localization of huntingtin (zeige HTT Proteine) to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein.

  2. The study showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (zeige PALB2 Proteine), CHEK2 (zeige CHEK2 Proteine) and ATM

  4. Taken together, the findings suggest that a protein-protein interaction between ATM and p400 ATPase occurs independently of DNA damage and contributes to efficient DNA damage response and repair.

  5. following reprogramming the early and late replicating genome is differentially affected by copy number variations in ATM-deficient induced pluripotent stem cells (iPSCs) relative to wild-type iPSCs.

  6. ATM mutation is associated with ataxia (zeige USP14 Proteine)-telangiectasia.

  7. Results provide evidence that ATM along with 53BP1 (zeige TP53BP1 Proteine) is involved in breast cancer cells resistance for PARP inhibitor; its deficiency causes resistance in 53BP1 (zeige TP53BP1 Proteine)-depleted tumor cells.

  8. WRNIP1 (zeige WRNIP1 Proteine) connects PCNA (zeige PCNA Proteine) monoubiquitination with ATMIN (zeige ATMIN Proteine)/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  9. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  10. ATM rs189037 polymorphism is associated with reduced risk of T2DM

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. Ataxia (zeige USP14 Proteine) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. radiation-induced eNOS (zeige NOS3 Proteine) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (zeige HSP90 Proteine)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA (zeige PCNA Proteine)- and ATM/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.

  2. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects

  3. This study show that like ataxia (zeige USP14 Proteine) telangiectasia cells, ISG15 (zeige ISG15 Proteine) is elevated in Atm-deficient mouse cerebellums.

  4. This study identifies attenuation of type I interferon (zeige IFNA Proteine) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.

  5. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  6. USP7 (zeige USP7 Proteine) inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 (zeige TP53 Proteine) and synergizes with chemotherapy.

  7. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53 (zeige TP53 Proteine)/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (zeige CRK Proteine) in response to prolonged exposure to IR.

  8. ATM, ATR and DNA-PKcs (zeige PRKDC Proteine) have unique and essential roles during the DNA damage response in the nervous system.

  9. TRAF6 (zeige TRAF6 Proteine) and H2AX (zeige H2AFX Proteine) overexpression and gammaH2AX (zeige H2AFX Proteine)-mediated HIF1alpha (zeige HIF1A Proteine) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (zeige HIF1A Proteine)-driven tumorigenesis, glycolysis and metastasis.

  10. These results reveal a new requirement for ATMIN (zeige ATMIN Proteine)-dependent ATM signaling in TP53 (zeige TP53 Proteine)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

ATM Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu)
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated (ATM)
  • ataxia telangiectasia mutated (EDI_100660)
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772)
  • ataxia telangiectasia mutated (BDBG_08252)
  • ataxia telangiectasia mutated (PAAG_02532)
  • ataxia telangiectasia mutated (MCYG_05088)
  • ataxia telangiectasia mutated (VDBG_06833)
  • ataxia telangiectasia mutated (atm) (ACLA_015700)
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900)
  • ataxia telangiectasia mutated (MGYG_07634)
  • ataxia telangiectasia mutated (PGTG_14279)
  • ataxia telangiectasia mutated (Atm)
  • ataxia telangiectasia mutated (LOC100349299)
  • ataxia telangiectasia mutated homolog (human) (Atm)
  • AI256621 Protein
  • AT1 Protein
  • ATA Protein
  • ATC Protein
  • ATD Protein
  • ATDC Protein
  • ATE Protein
  • atm Protein
  • atm/tefu Protein
  • C030026E19Rik Protein
  • CG6535 Protein
  • dATM Protein
  • Dmel\\CG6535 Protein
  • tef Protein
  • Tefu Protein
  • TEL1 Protein
  • TELO1 Protein
  • Xatm Protein

Bezeichner auf Proteinebene für ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

GENE ID SPEZIES
41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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