Thyroid Hormone Receptor, beta Proteine (THRB)

Bezeichnung:
Thyroid Hormone Receptor, beta Proteine (THRB)
Auf www.antikoerper-online.de finden Sie aktuell 11 Thyroid Hormone Receptor, beta (THRB) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Thyroid Hormone Receptor, beta Antikörper (129) und Thyroid Hormone Receptor, beta Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 153 Thyroid Hormone Receptor, beta Produkte verfügbar.
Synonyme:
C-ERBA-2, C-ERBA-BETA, c-erbAbeta, CTR BETA 2, ERBA2, fj24f03, GRTH, LOC734147, Nr1a2, PRTH, RATT3REC, T3Rbeta, T3rec, T3R[b], THR, THR1, THRB, THRB1, THRB2, TR-BETA, trb, TRbeta, TRbeta1, TR[b]1, wu:fj24f03
alle Proteine anzeigen Gen GeneID UniProt
THRB 24831  
THRB 21834 P37242
THRB 7068 P10828

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Weitere Proteine zu Thyroid Hormone Receptor, beta Interaktionspartnern

Mouse (Murine) Thyroid Hormone Receptor, beta (THRB) Interaktionspartner

  1. Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (zeige IHH Proteine) gene.

  2. In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (zeige SMAD1 Proteine) signaling.

  3. Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.

  4. Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development.

  5. Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC (zeige MYC Proteine) expression.

  6. T3 induces FGF21 (zeige FGF21 Proteine) in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE (zeige TREH Proteine) within intron 2 of FGF21 (zeige FGF21 Proteine). But T3 induced most gene expression in liver independently of FGF21 (zeige FGF21 Proteine).

  7. TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 (zeige ECM1 Proteine) regulatory subunit of PI3K and the Src kinase (zeige CSK Proteine) Lyn (zeige LYN Proteine) in the absence of thyroid hormone (zeige PTH Proteine).

  8. TRbeta-related deafness originates outside of hair cells and that TRalpha (zeige GNAT1 Proteine) and TRbeta play opposing, non-redundant roles in hair cells.

  9. Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII (zeige NR2F2 Proteine).

  10. these data indicate that interactions between NCoR1 (zeige NCOR1 Proteine) and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance.

Zebrafish Thyroid Hormone Receptor, beta (THRB) Interaktionspartner

  1. Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (zeige PTH Proteine) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.

  2. Data suggest that the embryonic to larval transitory phase is characterized by its dependency on the timely synthesis of thyroid hormone (zeige PTH Proteine) and the concomitant autoinductive increase in thyroid hormone receptor beta mRNA levels.

Human Thyroid Hormone Receptor, beta (THRB) Interaktionspartner

  1. The present studies uncovered a novel mechanism by which thyroid hormone receptor beta could function as a tumor suppressor through modulation of TNF alpha-IkappaB alpha-NFkappaB pathway.

  2. Novel THRB single nucleotide substitution-C to G in codon 340 in resistance to thyroid hormone (zeige PTH Proteine) syndrome.

  3. THRA (zeige THRA Proteine) predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation.

  4. TRbeta (zeige TXNRD2 Proteine) suppressed Runx2 (zeige RUNX2 Proteine) transcriptional activities, thus confirming TRbeta (zeige TXNRD2 Proteine) regulation of Runx2 (zeige RUNX2 Proteine) at functional thyroid hormone (zeige PTH Proteine)-response elements. Significantly, these findings indicate that a ratio of the tumor-suppressor TRbeta (zeige TXNRD2 Proteine) and tumor-promoting Runx2 (zeige RUNX2 Proteine) may reflect tumor aggression and serve as biomarkers in biopsy tissues. The discovery of this TRbeta (zeige TXNRD2 Proteine)-Runx2 (zeige RUNX2 Proteine) signaling supports the emerging role of TRbeta (zeige TXNRD2 Proteine) as a tumor supp...

  5. results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 (zeige PDCD4 Proteine) and THRB

  6. it was observed that ER stimulated gene expression by interacting with MEIS1 (zeige MEIS1 Proteine) and FOXP3 (zeige FOXP3 Proteine), and ER inhibited gene expression by interacting with THRB and GRHL1 (zeige GRHL1 Proteine).

  7. presents 1 pedigree of thyroid hormone (zeige PTH Proteine) resistance syndrome with heterozygous A317T mutation in THRbeta gene in the proband and his mother, which is the first reported mutation in Chinese and provides a comprehensive review of available literature

  8. Molecular cloning and detection of TR beta isoform 4 in pituitary cells.

  9. p.H271D mutation associated with resistance thyroid hormone (zeige PTH Proteine) syndrome

  10. diagnosis was confirmed by direct THRB sequencing that revealed 2 novel mutations: the heterozygous p.Ala317Ser in subject 1 and the heterozygous p.Arg438Pro in subject 2

Cow (Bovine) Thyroid Hormone Receptor, beta (THRB) Interaktionspartner

  1. Increased expression of mammary TRbeta1 and DIO2 (zeige DIO2 Proteine), and decreased RXRalpha (zeige RXRA Proteine), provide a mechanism to increase thyroid hormone (zeige PTH Proteine) activity within the mammary gland during lactation.

Thyroid Hormone Receptor, beta (THRB) Protein Überblick

Protein Überblick

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Alternative names and synonyms associated with Thyroid Hormone Receptor, beta (THRB)

  • thyroid hormone receptor beta (LOC734147)
  • thyroid hormone receptor beta (thrb)
  • thyroid hormone receptor (ERBA BETA1)
  • thyroid hormone receptor beta (Thrb)
  • thyroid hormone receptor, beta (THRB)
  • C-ERBA-2 Protein
  • C-ERBA-BETA Protein
  • c-erbAbeta Protein
  • CTR BETA 2 Protein
  • ERBA2 Protein
  • fj24f03 Protein
  • GRTH Protein
  • LOC734147 Protein
  • Nr1a2 Protein
  • PRTH Protein
  • RATT3REC Protein
  • T3Rbeta Protein
  • T3rec Protein
  • T3R[b] Protein
  • THR Protein
  • THR1 Protein
  • THRB Protein
  • THRB1 Protein
  • THRB2 Protein
  • TR-BETA Protein
  • trb Protein
  • TRbeta Protein
  • TRbeta1 Protein
  • TR[b]1 Protein
  • wu:fj24f03 Protein

Bezeichner auf Proteinebene für THRB

thyroid hormone receptor beta , nuclear receptor subfamily 1 group A member 2 , thyroid hormone receptor beta isoform , TRbeta2Delta , c-erbA-2 , thyroid hormone receptor beta 3 , thyroid hormone receptor beta2delta , thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2) , TR beta , c-erbA-beta , TRbeta1 , thyroid hormone receptor beta 1 , thyroid hormone receptor beta 2 , thyroid hormone receptor beta-1 , oncogene ERBA2 , thyroid hormone nuclear receptor beta variant 1 , thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) , thyroid hormone receptor beta2 , beta-thyroid hormone receptor

GENE ID SPEZIES
734147 Xenopus (Silurana) tropicalis
100049254 Oryzias latipes
100136934 Salmo salar
443445 Ovis aries
24831 Rattus norvegicus
21834 Mus musculus
30607 Danio rerio
7068 Homo sapiens
100303763 Oryctolagus cuniculus
403599 Canis lupus familiaris
788329 Bos taurus
396431 Gallus gallus
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