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Human Retinoic Acid Receptor alpha Protein expressed in Wheat germ - ABIN1317431
Schulz, Paus, Frey, Schmid, Kohl, Mennerich, Winkler, Gillardon: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. in PLoS ONE 2011
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High RARA expression is associated with acute myeloid leukemia (zeige BCL11A Proteine).
Data suggest that the binding of Z-10 to RXRalpha (zeige RXRA Proteine) inhibited the interaction of RXRalpha (zeige RXRA Proteine) with PML (zeige PML Proteine)-RARalpha, leading to Z-10's selective induction of PML (zeige PML Proteine)-RARalpha degradation.
PML (zeige PML Proteine)-RARa bcr1 (zeige BCR Proteine) fusion is not responsible for colorectal tumor development.
overexpression of NLS (zeige ALDH1A2 Proteine)-RARalpha promoted the proliferation of APL (zeige FASL Proteine) cells and inhibited their differentiation via the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathway.
r study demonstrated that ATRA cound promote differentiation while inhibit proliferation of acute promyelocytic leukemia (zeige PML Proteine) NB4 cells via activating p38a (zeige MAPK14 Proteine) protein after recruiting p38a (zeige MAPK14 Proteine)-combinded NLS (zeige ALDH1A2 Proteine)-RARa, while NLS (zeige ALDH1A2 Proteine)-RARa could inhibit the effects of ATRA in the process.
Low expression of RARalpha was independently associated with worse progression-free survival following platinum-based chemotherapy of advanced Non-small cell lung cancer.
The classical counterpart of RARalpha, retinoid X receptor alpha (RXRalpha (zeige RXRA Proteine)), was down-regulated in both cytoplasm and nucleus of A549 cells upon atRA addition.
RAI1 (zeige DOM3Z Proteine) polymorphisms rs4925102 and rs9907986 are predicted to disrupt the binding of retinoic acid RXR-RAR receptors and the transcription factor DEAF1 (zeige DEAF1 Proteine), respectively, in Smith-Magenis and Potocki-Lupski syndromes patients.
Data suggest that hematopoietically expressed homeobox protein (HHEX (zeige HHEX Proteine)) downmodulation by promyelocytic leukemia (zeige PML Proteine)-retinoic acid receptor alpha fusion oncoprotein (PML (zeige PML Proteine)-RARalpha) is a key event during acute promyelocytic leukemia (zeige PML Proteine) (APL (zeige FASL Proteine)) pathogenesis.
ATRA dramatically down regulated RARalpha protein levels and led to more DNA damage and ultimately resulted in the synergism of these two agents
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (zeige FOXO3 Proteine)/p-Akt (zeige AKT1 Proteine)/Foxo1 (zeige FOXO1 Proteine) signaling.
both the PML (zeige PML Proteine)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (zeige PML Proteine) (APL (zeige FASL Proteine)) required DNMT3A (zeige DNMT3A Proteine)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (zeige WNT2 Proteine) signalling through physical interactions of RARs (zeige RARS Proteine) with beta-catenin (zeige CTNNB1 Proteine).
our findings challenge the predominant model in the field and we propose that PML (zeige PML Proteine)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (zeige PML Proteine)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (zeige LGALS4 Proteine)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (zeige CSF2 Proteine)-induced retinal dehydrogenase 2 (RALDH2 (zeige ALDH1A2 Proteine)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (zeige SP1 Proteine) via the RA receptor/retinoid X receptor (zeige RXRB Proteine) complex to the Aldh1a2 (zeige ALDH1A1 Proteine) promoter.
Retinoic acid-RARalpha as a key component of the regulatory network governing maintenance and plasticity of Th1 (zeige HAND1 Proteine)-cell fate.
Increased expression of mammary TRbeta1 (zeige THRB Proteine) and DIO2 (zeige DIO2 Proteine), and decreased RXRalpha (zeige RXRA Proteine), provide a mechanism to increase thyroid hormone (zeige PTH Proteine) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (zeige RARB Proteine) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (zeige RAB40B Proteine) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform