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Transgenic mouse line expressing the human Ki-Ras bearing an activating mutation (Ki-Ras((G12V))) selectively in the mammary epithelium develop estrogen receptor alpha (ERalpha)-positive ductal adenocarcinomas with 100% incidence within 3-9 months after Ki-Ras((G12V)) induction.
Lupus-prone ERalpha -/- mice are not protected from lupus disease expression if ovariectomized.
Taken together, the above results clearly demonstrated an mTORC2 (zeige CRTC2 Proteine)-dependent regulation of actin polymerization that contributed to the effects of ERalpha and ERbeta (zeige ESR2 Proteine) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
These findings suggest that RASD1 (zeige RASD1 Proteine) acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
Truncating mutations of Prlr (zeige PRLR Proteine) promote tumor growth in a model of human ERalpha+ breast cancer.
This comparative study documented the complexity of ERalpha genes, mRNAs, and proteins, and further determined the underlying structural basis of ligand-independent activation by C-terminally-truncated ERalpha variants.
E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C (zeige NPPC Proteine) and natriuretic peptide receptor 2 (NPPC (zeige NPPC Proteine)/NPR2 (zeige NPRL2 Proteine))
Ventromedial hypothalamus neurons expressing Esr1 are indispensable for female aggression.
Increased DNA methylation (zeige HELLS Proteine) accompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC-binding factor (zeige CTCF Proteine) of ESR1 and ESR2 (zeige ESR2 Proteine), consistent with sustained transcriptional activation of ERa and ERb (zeige ESR2 Proteine)
Ciliary length and beat frequency of the oviductal epithelial cells are regulated through ESR1.
ESR1 inhibits the expression of Pitx2 (zeige PITX2 Proteine) gene by binding to a left side-specific enhancer region in Pitx2 (zeige PITX2 Proteine) gene and recruiting histone deacetylase 1 (zeige HDAC1 Proteine) to this region, leading to the suppression of Pitx2 (zeige PITX2 Proteine) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (zeige PGR Proteine) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (zeige FSHB Proteine), ESR, and PRLR (zeige PRLR Proteine) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (zeige COX8A Proteine) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (zeige ESR2 Proteine) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (zeige ESR2 Proteine)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (zeige ESR2 Proteine) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (zeige ESR2 Proteine) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (zeige ESR2 Proteine) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (zeige ESR2 Proteine), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (zeige ESR2 Proteine) and ERbeta-B and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha and ER-beta (zeige ESR2 Proteine) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (zeige PGR Proteine) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (zeige ESR2 Proteine) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (zeige CYP19A1 Proteine) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (zeige ESR2 Proteine) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (zeige SNRPB Proteine)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (zeige TNF Proteine) and IFNgamma regulate ERalpha and ERbeta (zeige ESR2 Proteine) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
Neoadjuvant tamoxifen treatment synchronized ERalpha/chromatin interactions and downstream gene expression related to treatment outcome and cell proliferation.
Transcriptional down-regulation of ESR1 mRNA could contribute to the selective activity of neo-tanshinlactone on ER+ breast cancer cells.
Despite the large concordance between P and matched M for the evaluated molecular alterations, potential actionable targets such as ESR1 mutations were found only in M. This supports the importance of characterizing the M disease. Other targets we identified, such as HIF1A (zeige HIF1A Proteine) and IDO1 (zeige IDO1 Proteine), warrant further investigation in this patient population.
Novel ESR1 mutations that constitutively activate the receptor and promote breast cancer phenotypes.
Studies indicate that in the presence of estrogen receptor alpha (ERa), AR may antagonize the ERalpha-induced effects, whereas in the absence of estrogens, AR may act as an ERalpha-mimic, promoting tumor.
The GG genotype of ERalpha XbaI polymorphism could be a genetic risk factor for PE predisposition.
Data show that the combination of Bacillus Calmette-Guerin (BCG (zeige SLC11A1 Proteine)) and the anti-estrogen/estrogen receptor ICI 182,780 led to better suppression of bladder cancer (BCa (zeige BLNK Proteine)) than BCG (zeige SLC11A1 Proteine) alone.
Combined targeting of XPO1 (zeige XPO1 Proteine) and ERalpha in several tamoxifen-resistant cell lines and tumor xenografts with the XPO1 (zeige XPO1 Proteine) inhibitor, Selinexor, and tamoxifen restored tamoxifen sensitivity and prevented recurrence in vivo.
The role of estrogens in the regulation of ZO-1 (zeige TJP1 Proteine) and estrogen receptors 1 and 2 was evaluated in human primary gut (zeige GUSB Proteine) tissues by immunohistochemistry, immunofluorescence and qPCR.
we have herein demonstrated that ERalpha expression associates with MDM4 (zeige MDM4 Proteine) and MDM2 (zeige MDM2 Proteine) gene expression in primary breast invasive carcinoma samples
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
, ERA-like GTPase
, ERA-like protein 1
, GTP-binding protein era homolog
, GTPase Era, mitochondrial
, conserved ERA-like GTPase
, estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor