anti-Presenilin 1 (PSEN1) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 270 Presenilin 1 (PSEN1) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Presenilin 1 Kits (33) und Presenilin 1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 332 Presenilin 1 Produkte verfügbar.
Synonyme:
AD3, Ad3h, FAD, pre1, PS-1, PS1, psen, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1
Alle Antikörper anzeigen Gen GeneID UniProt
PSEN1 5663 P49768
PSEN1 19164 P49769
PSEN1 29192 P97887

Meistgesuchte Reaktivitäten zu anti-Presenilin 1 (PSEN1) Antikörper

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Weitere Antikörper gegen Presenilin 1 Interaktionspartner

Zebrafish Presenilin 1 (PSEN1) Interaktionspartner

  1. Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation

  2. We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish

  3. These results suggest that Psen2 (zeige PSEN2 Antikörper) plays a more prominent role in Notch (zeige NOTCH1 Antikörper) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (zeige PSEN2 Antikörper) can be ameliorated by Psen1 loss.

Human Presenilin 1 (PSEN1) Interaktionspartner

  1. proapoptotic signaling pathways c-Jun NH2-terminal kinase (zeige MAPK8 Antikörper) and p38 mitogen-activated protein kinase (zeige MAPK14 Antikörper) maintained PSEN1-mediated negative regulation in K239N but not in E120G-bearing cells

  2. increased mitochondrial calcium due to the gain-of-function enhancement of IP3R (zeige ITPR1 Antikörper) channels in the cells expressing PS1-M146L leads to the opening of permeability transition pore in high conductance state.

  3. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein (zeige APP Antikörper), Presenilin 1, and Presenilin 2 (zeige PSEN2 Antikörper) as a cause of autosomal dominant AD

  4. The authors now show that the very little Abeta (zeige APP Antikörper) generated by PS1 L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  5. APP (zeige APP Antikörper) + PS1 double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP (zeige APP Antikörper) rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP (zeige APP Antikörper) + PS1 rats showed brain pathology as well as reduced memory retention compared to the APP (zeige APP Antikörper) and the ...

  6. gamma-Secretase is a multimeric membrane protease involved in processing of the amyloid precursor protein (zeige APP Antikörper) with high clinical relevance as mutations in its catalytic subunit (Presenilin) cause early-onset Alzheimer's disease

  7. Using purified PSEN1/Aph1A (zeige APH1A Antikörper) gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP (zeige APP Antikörper); present a unifying model for how PSEN or APP (zeige APP Antikörper) mutations enhance amyloidogenic Abeta (zeige APP Antikörper) production, suggests that environmental factors may increase Alzheimer's Disease risk.

  8. Findings do not provide significant support for presenilin 1 (PSEN1) E318G as a risk factor for Alzheimer's disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.

  9. Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b (zeige aph1b Antikörper)), presenilin 2 (PS2 (zeige PSEN2 Antikörper))/Aph1aL, PS2 (zeige PSEN2 Antikörper)/Aph1aS and PS2 (zeige PSEN2 Antikörper)/anterior pharynx defective 1 homolog B (Aph1b (zeige aph1b Antikörper)) gamma-secretase produced amyloid beta peptide (Abeta (zeige APP Antikörper)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  10. PSEN1 mutations are associated with specific AD phenotype.

Mouse (Murine) Presenilin 1 (PSEN1) Interaktionspartner

  1. Study shows that the binding of HSF-1 (zeige HSF1 Antikörper), Cdx1 (zeige CDX1 Antikörper), Ets-1 (zeige ETS1 Antikörper) and Sp1 (zeige SP1 Antikörper) to Presenilin 1 promoter and that of Nkx2.2 (zeige Nkx2-2 Antikörper), HFH-2 (zeige FOXD3 Antikörper), Cdx1 (zeige CDX1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) to Presenilin 2 (zeige PSEN2 Antikörper) promoter regulate their differential expression during brain development.

  2. conclusion that the PSEN1 mutations are extreme examples of the previously proposed ''dysfunction'' of gamma-secretase that characterizes familial Alzheimer's disease

  3. PS1 expression is triggered by glutamate (zeige GRIN1 Antikörper) through p38alpha (zeige MAPK14 Antikörper), contributing to the excitotoxic stimulus of EW

  4. amino acid sensing of mechanistic target of rapamycin (zeige FRAP1 Antikörper) complex 1 (mTORC1) is dysregulated in cells deficient in presenilin.

  5. the G206D mutation reduced presenilin-1-presenilin enhancer 2 (zeige PSENEN Antikörper) interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis

  6. This study deals with the effect of attenuated endoproteolysis of PS1 on store-operated calcium (SOC (zeige UBXN11 Antikörper)) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2 (zeige PDCD6 Antikörper)

  7. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 (zeige PDCD6 Antikörper) during cerebral cortical development

  8. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP (zeige APP Antikörper)/PS1 mice

  9. PS1 deficiency depletes vATPase (zeige ATP6V1H Antikörper), impairing lysosomal acidification and calcium homeostasis.

  10. Abeta (zeige APP Antikörper) oligomers in the cerebrospinal fluid (CSF (zeige CSF2 Antikörper)) further promoted the expression of APH-1alpha (zeige APH1A Antikörper)/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (zeige APP Antikörper) and Abeta (zeige APP Antikörper) deposition during AD progression

Pig (Porcine) Presenilin 1 (PSEN1) Interaktionspartner

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Antikörper) and PSEN1 genes via a STAT3 (zeige STAT3 Antikörper)-dependent pathway

Cow (Bovine) Presenilin 1 (PSEN1) Interaktionspartner

  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (zeige FLT1 Antikörper)

Presenilin 1 (PSEN1) Antigen-Profil

Beschreibung des Gens

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alternative names and synonyms associated with Presenilin 1 (PSEN1)

  • presenilin 1 (psen1) Antikörper
  • presenilin 1 (PSEN1) Antikörper
  • presenilin 1 (Psen1) Antikörper
  • AD3 Antikörper
  • Ad3h Antikörper
  • FAD Antikörper
  • pre1 Antikörper
  • PS-1 Antikörper
  • PS1 Antikörper
  • psen Antikörper
  • S182 Antikörper
  • X-PS-alpha Antikörper
  • X-PS-beta Antikörper
  • zf-PS1 Antikörper
  • zfPS1 Antikörper

Bezeichner auf Proteinebene für anti-Presenilin 1 (PSEN1) Antikörper

PS-1 , presenilin-1 , presenilin 1 (Alzheimer disease 3) , presenilin-1 isoform I-463 , presenilin-1 isoform I-467 , presenilin 1 , presenilin-1-like , PS-alpha , presenilin alpha , presenilin-alpha

GENE ID SPEZIES
30221 Danio rerio
394924 Xenopus (Silurana) tropicalis
739740 Pan troglodytes
100173083 Pongo abelii
696274 Macaca mulatta
100401034 Callithrix jacchus
100586383 Nomascus leucogenys
5663 Homo sapiens
19164 Mus musculus
29192 Rattus norvegicus
373977 Gallus gallus
403408 Canis lupus familiaris
780411 Sus scrofa
282705 Bos taurus
100008886 Oryctolagus cuniculus
399258 Xenopus laevis
100728153 Cavia porcellus
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