TNFSF11 Proteine (TNFSF11)

Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Proteine (TNFSF11)
Auf finden Sie aktuell 75 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TNFSF11 Antikörper (324) und TNFSF11 Kits (118) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 534 TNFSF11 Produkte verfügbar.
BTF3L1, CD254, hRANKL2, HUMBTFB, Ly109l, OCIF, ODF, Opg, OPGL, OPTB2, RANKL, sOdf, TNFRSF11B, TNFSF11, Trance
alle Proteine anzeigen Gen GeneID UniProt
TNFSF11 690  
TNFSF11 21943 O35235
TNFSF11 117516 Q9ESE2

Weitere Synonyme anzeigen

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Am meisten referenzierte TNFSF11 Proteine

  1. Human TNFSF11 Protein expressed in HEK-293 - ABIN2666867 : Dehm, Bonham: SRC gene expression in human cancer: the role of transcriptional activation. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004 (PubMed)
    Zeige alle 8 Referenzen für 2666867

  2. Mouse (Murine) TNFSF11 Protein expressed in Insect Cells - ABIN2666593 : Ha, Choi, Lee, Kwon, Song, Kim: CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Zeige alle 7 Referenzen für 2666593

  3. Human TNFSF11 Protein expressed in Human Cells - ABIN2004520 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
    Zeige alle 3 Referenzen für 2004520

  4. Cynomolgus TNFSF11 Protein expressed in Human Cells - ABIN2010125 : Nagai, Kyakumoto, Sato: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. in Biochemical and biophysical research communications 2000 (PubMed)
    Zeige alle 3 Referenzen für 2010125

  5. Mouse (Murine) TNFSF11 Protein expressed in HEK-293 Cells - ABIN1344301 : Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

Weitere Proteine zu TNFSF11 Interaktionspartnern

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Interaktionspartner

  1. Correlations between sRANKL and IL-18 (zeige IL18 Proteine) in BALF.

  2. RANK/RANKL signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (zeige TNFRSF11B Proteine) to prevent bone metastasis.

  3. This study suggested that RANKL could be a marker to differentiate between pagetoid squamous cell carcinoma in situ and extramammary Paget disease .

  4. TNF-alpha-converting enzyme (zeige ADAM17 Proteine) -mediated cleavage of soluble RANKL from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  5. RANKL is required for progesterone-mediated cell proliferation in BRCA1mut/+ breast tissue.

  6. MAOA (zeige MAOA Proteine) provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6 (zeige IL6 Proteine)) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6 (zeige IL6 Proteine).

  7. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  8. The results showed that AG490 inhibited (p)-JAK2 (zeige JAK2 Proteine) and RANKL expression.

  9. Review: OPG (zeige TNFRSF11B Proteine), RANKL and TRAIL are involved in vascular calcification.

  10. Our results suggest that the polymorphism of the RANKL, RANK, and OPG (zeige TNFRSF11B Proteine) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Interaktionspartner

  1. sRANKL increased macrophage glucose uptake at normal glucose concentrations, which was impaired by hyperglycemia pretreatment through the inhibition of Glut1 (zeige SLC2A1 Proteine) membrane translocation and the insulin receptor (zeige INSR Proteine) and IRS-1 (zeige IRS1 Proteine) gene transcription.

  2. Our findings show that anti-RANKL antibody administration during pregnancy results in not only an undesirable increase in bone mass, but also has harmful effects on newborn survival.

  3. RANKL represses the transcription of the E3 ubiquitin ligase (zeige MUL1 Proteine) RNF146 (zeige RNF146 Proteine) through an NF-kappaB (zeige NFKB1 Proteine)-related inhibitory element in the RNF146 (zeige RNF146 Proteine) promoter.

  4. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2 (zeige NFE2L2 Proteine)-mediated antioxidant enzyme expression by competing with Bach1 (zeige BACH1 Proteine) nuclear accumulation.

  5. Membrane-bound RANKL induces M cell differentiation and CCL20 (zeige CCL20 Proteine) expression in the follicle associated epithelium of gut (zeige GUSB Proteine)-associated lymphoid tissues.

  6. The data show that S. aureus enhances bone resorption and periosteal osteoclast formation by increasing osteoblast RANKL production through TLR2.

  7. Data (including data from studies using knockout mice) suggest that RANKL enhances TNF (zeige TNF Proteine)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 (zeige TRAF6 Proteine) by degrading Traf3 (zeige TRAF3 Proteine), a known inhibitor of osteoclastogenesis. (RANKL = osteoclast differentiation factor; TNF (zeige TNF Proteine) = tumor necrosis factor (zeige TNF Proteine); Traf (zeige TRAF1 Proteine) = TNF (zeige TNF Proteine) receptor-associated factor)

  8. Results suggest that MAPK (zeige MAPK1 Proteine) signaling pathway is necessary for receptor activator of nuclear factor kappa-B ligand (RANKL) expression in bone marrow stromal cell.

  9. endocortical resorption is driven by reduced osteoprotegerin (zeige TNFRSF11B Proteine) rather than elevated RANKL expression

  10. The results showed that AG490 inhibited (p)-JAK2 (zeige JAK2 Proteine) and RANKL expression.

TNFSF11 Protein Überblick

Protein Überblick

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

  • tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11)
  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • BTF3L1 Protein
  • CD254 Protein
  • hRANKL2 Protein
  • HUMBTFB Protein
  • Ly109l Protein
  • OCIF Protein
  • ODF Protein
  • Opg Protein
  • OPGL Protein
  • OPTB2 Protein
  • RANKL Protein
  • sOdf Protein
  • TNFRSF11B Protein
  • TNFSF11 Protein
  • Trance Protein

Bezeichner auf Proteinebene für TNFSF11

tumor necrosis factor (ligand) superfamily, member 11 , tumor necrosis factor ligand superfamily member 11 , Receptor activator of nuclear factor kappa-B ligand , TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

467353 Pan troglodytes
513836 Bos taurus
609418 Canis lupus familiaris
699955 Macaca mulatta
100599838 Nomascus leucogenys
690 Homo sapiens
8600 Homo sapiens
21943 Mus musculus
117516 Rattus norvegicus
25341 Rattus norvegicus
378803 Gallus gallus
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