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These results show an unclear effect of considered T>C polymorphism on TNF-RII gene expression in bovine leukocytes and they suggest the involvement of BLV in modifying the TNF-RII expression in BLV-infected cows.
These results suggest that the endometrium might lower the TNF (zeige TNF Proteine) concentration in the blastocyst by (1) regulating TNF (zeige TNF Proteine) secretion into the uterine fluid and (2) inducing decreased TNF (zeige TNF Proteine) and TNFR2 mRNA transcription in the embryo.
These results suggest that TNF-alpha (zeige TNF Proteine) sources include immune cells, as well as large and small luteal cells, and that TNF-RI (zeige TNFRSF1A Proteine) and TNF-RII are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (zeige TNF Proteine)) and its receptors (TNFRI (zeige TNFRSF1A Proteine) and TNFRII) mRNAs and proteins, were determined.[TNFRII]
Data suggest that, by targeting tumor cells and immunosuppressive tumor-associated Tregs, antagonistic tumor necrosis factor receptor 2 (TNFR2) antibodies may be an effective treatment for cancers positive for TNFR2.
p75 neurotrophin receptor (zeige NGFR Proteine) (p75TNFR) was the first NGFR (nerve growth factor receptor (zeige NGFR Proteine)) to be cloned and the founding member of the TNFR (zeige TNFRSF1A Proteine) (tumor necrosis factor (zeige TNF Proteine) receptor) superfamily. However, data suggest that p75TNF is an atypical TNFR (zeige TNFRSF1A Proteine) superfamily protein; p75TNFR forms dimers (activated by dimeric neurotrophins) that are structurally unrelated to TNFR (zeige TNFRSF1A Proteine) superfamily proteins. [REVIEW]
High plasma levels of TNFR2 and TNFR1 (zeige TNFRSF1A Proteine) were associated with incident intracerebral hemorrhage.
this study shows that TNFalpha (zeige TNF Proteine) significantly augments IFNgamma production from IL-2 (zeige IL2 Proteine)-/IL-12 (zeige IL12A Proteine)-treated NK cells in vitro, an effect mimicked by a TNFR2 agonistic antibodies
TRIM28 (zeige TRIM28 Proteine) acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 (zeige TNFRSF1A Proteine) and -2 and VEGF receptor 2 in endothelial cells
Serum TNFR2 levels were elevated in lupus nephritis patients versus controls.
Adalimumab bound to monocyte membrane TNF (zeige TNF Proteine) from rheumatoid arthritis patients and unexpectedly enhanced its expression and its binding to TNF-RII expressed on T reg (zeige EXTL3 Proteine) cells.
Voxel-based morphometry was used to analyse the associations between TNFRSF1B (rs1061624) genotypes and grey matter structure. Analysis of the TNFRSF1B SNP rs1061624 yielded a significant association with hippocampal but not with striatal volume, whereby G homozygotes were associated with increased volumes relative to A homozygotes and heterozygotes.
Circulating TNFR1 (zeige TNFRSF1A Proteine) and 2 were shown to be associated with cardiovascular disease, independent of age, sex, inflammatory markers, and other cardiovascular disease risk factors, in the chronic kidney disease patients
Data suggest that TRAF2 (TNF receptor-associated factor 2 (zeige TRAF2 Proteine)) negatively regulates (1) TNFR1- (tumor necrosis factor binding protein 1 (zeige TNFRSF1A Proteine))-induced apoptosis, (2) TNFR2- (tumor necrosis factor (zeige TNF Proteine) receptor type 2)-induced non-canonical NFkappaB (zeige NFKB1 Proteine) signaling, and (3) TNF- (tumor necrosis factor (zeige TNF Proteine))-induced necroptosis. [REVIEW]
TNFR2 sensitizes macrophages for endogenous TNF (zeige TNF Proteine)-induced TNFR1 (zeige TNFRSF1A Proteine)-mediated necroptosis
study reports an important role for TNFR2 on low-affinity-primed secondary effector CD8 (zeige CD8A Proteine)+ T cells; results demonstrate the importance of TNF (zeige TNF Proteine) signaling in low-affinity, cross-reactive CD8 (zeige CD8A Proteine)+ T cell responses during heterologous immunity
TNF (zeige TNF Proteine) plays an inhibitory role in modulating myocardial SDF-1 (zeige CXCL12 Proteine) production and blockade of TNF (zeige TNF Proteine) signaling by ablation of TNFR1 (zeige TNFRSF1A Proteine) and TNFR2 genes increased SDF-1 (zeige CXCL12 Proteine) expression in the heart. These data expand on TNF (zeige TNF Proteine) signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 (zeige CXCL12 Proteine) and TNFR (zeige TNFRSF1A Proteine)-derived actions in hopes of advancing ischemic heart injury treatments.
Results suggest that elevated TNF (zeige TNF Proteine) in the heart, via TNFR1 (zeige TNFRSF1A Proteine) and TNFR2, restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.
Report chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced by oral dibutyltin administration in TNFR1 (zeige TNFRSF1A Proteine)/R2 deficient mice.
These findings implicate TNF (zeige TNF Proteine)-receptor signaling cascades in the regulation of homeostatic plasticity of denervated networks and suggest an important role for TNFalpha (zeige TNF Proteine)-signaling in the course of neurological diseases accompanied by deafferentation.
TNF (zeige TNF Proteine) receptor 1 (TnfR1 (zeige TNFRSF1A Proteine)) signaling is believed to be a major mediator of the cytotoxicity of Tnf-a (zeige TNF Proteine) through activation of caspases.
our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver
TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice.
TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8 (zeige CD8A Proteine)(+) T cells.
Retinal ischemia results in increased expression of TNF-alpha (zeige TNF Proteine) and its receptors (TNF-R1 (zeige TNFRSF1A Proteine) and TNF-R2).
Porcine TNFR2 (1,125 bp, 375 amino acid residues), which contains specific amino acid region of transmembrane, indicated high identities with human and murine TNFR2
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
TNF receptor-associated factor 2
, E3 ubiquitin-protein ligase TRAF6
, TNF receptor-associated factor 6
, TNF receptor-associated factor 3
, TRAF family member-associated NFKB activator
, TNF receptor-associated factor 2-like
, tumor necrosis factor receptor superfamily member 1B
, tumor necrosis factor receptor 2
, tumor necrosis factor receptor superfamily, member 1B
, p75 TNF receptor
, p80 TNF-alpha receptor
, soluble TNFR1B variant 1
, tumor necrosis factor beta receptor
, tumor necrosis factor binding protein 2
, tumor necrosis factor receptor type II
, TNF receptor beta chain
, p75 TNFR
, tumor necrosis factor receptor-II