RIPK1 Proteine (RIPK1)

Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 Proteine (RIPK1)
Auf finden Sie aktuell 29 Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RIPK1 Antikörper (137) und RIPK1 Kits (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 191 RIPK1 Produkte verfügbar.
2400006N03Rik, C9orf12, D330015H01Rik, RGD1311271, Rinp, Rip, Rip1, rIpk1, RP23-83I13.5
alle Proteine anzeigen Gen GeneID UniProt
RIPK1 306808 Q5PXE9
RIPK1 8737 Q13546
RIPK1 19766 Q60855

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Weitere Proteine zu RIPK1 Interaktionspartnern

Human Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

  1. UL45 promoted the UL48-RIP1 (zeige UQCRFS1 Proteine) interaction and re-localization of RIP1 (zeige UQCRFS1 Proteine) to the UL48-containing virion assembly complex.

  2. we provide evidence that p62 (zeige GTF2H1 Proteine) is implicated in the activation of NF-kappaB (zeige NFKB1 Proteine) signaling that is partly dependent on RIP1 (zeige UQCRFS1 Proteine)

  3. inactivation of RIP1 (zeige UQCRFS1 Proteine)/RIP3 (zeige RIPK3 Proteine) resulted in reduction of SOCS1 (zeige SOCS1 Proteine) protein levels and partial differentiation of AML (zeige RUNX1 Proteine) cells. AML (zeige RUNX1 Proteine) cells with inactivated RIP1 (zeige UQCRFS1 Proteine)/RIP3 (zeige RIPK3 Proteine) signaling show increased sensitivity to IFN-gamma-induced (zeige SAMHD1 Proteine) differentiation.

  4. Data show that pan-caspase (zeige CASP3 Proteine) inhibitors facilitated 5-fluorouracil (5-FU)-induced necroptosis mediated by secretion of tumor necrosis factor alpha (TNF-alpha (zeige TNF Proteine)) driven by nuclear factor kappaB (NF-kappaB (zeige NFKB1 Proteine)) and required RIP1 (zeige UQCRFS1 Proteine) kinase.

  5. RIPK1 kinase activity is a pertinent therapeutic target to protect liver against excessive cell death in liver diseases.

  6. Ripk1 is directly involved in apoptosis/necroptosis. In osteosarcoma cells( OS) , small interfering RNA against Ripk1 prevented cell death induced by the sequestration of miR (zeige MLXIP Proteine)-155-5p. Collectively, we show that miR (zeige MLXIP Proteine)-148a-3p and miR (zeige MLXIP Proteine)-155-5p are species-conserved deregulated miRNA in OS

  7. RIPK1 collaborates with TRAF2 (zeige TRAF2 Proteine) to inhibit murine and human hepatocarcinogenesis.

  8. Necroptosis signaling is modulated by the kinase RIPK1 and requires the kinase RIPK3 and the pseudokinase MLKL. (Review)

  9. CYLD (zeige CYLD Proteine) Promotes TNF-alpha (zeige TNF Proteine)-Induced Cell Necrosis Mediated by RIP-1 (zeige UQCRFS1 Proteine) in Human Lung Cancer Cells

  10. TRAIL can enhance RIP1 (zeige UQCRFS1 Proteine) and c-FLIPL (zeige CFLAR Proteine) expression in HepG2 cells.

Mouse (Murine) Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Interaktionspartner

  1. MK2 (zeige KCNA2 Proteine)-mediated phosphorylation of RIPK1 serves as a checkpoint within the TNF (zeige TNF Proteine) signaling pathway that integrates cell survival and cytokine production.

  2. study identifies a novel role for RIPK1 and RIPK3 (zeige RIPK3 Proteine), a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta (zeige IFNB1 Proteine) production in macrophagesges.

  3. this study shows that RIPK1 and RIPK3 (zeige RIPK3 Proteine) account for acute inflammatory responses induced by lipopolysaccharide in vivo; notably, this regulation does not require exogenous manipulation of caspases

  4. these findings indicate that RIPK1 cooperates with NF-kappaB (zeige NFKB1 Proteine) signaling to prevent TNFR1 (zeige TNFRSF1A Proteine)-independent hepatocyte apoptosis and the development of chronic liver disease and cancer, but acts downstream of TNFR1 (zeige TNFRSF1A Proteine) signaling to promote diethylnitrosamine-induced liver tumorigenesis.

  5. this study reveals a critical kinase-independent platform role for RIPK1 in protecting against TNF (zeige TNF Proteine)/caspase (zeige CASP3 Proteine)-dependent apoptosis of hepatocytes in immune-mediated liver injury

  6. Results revealed that RIPK1 and PGAM5 (zeige PGAM5 Proteine) function independently to exert optimal control of Leishmania replication in the host.

  7. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both intracellular and extracellular PGRN (zeige GRN Proteine) protein levels by increasing the translation rate of PGRN (zeige GRN Proteine) without affecting mRNA levels.

  8. The findings reported here indicate that palmitate induces RIP1/RIP3-dependent necrosis via MLKL-mediated pore formation of RAW 264.7 cells in the plasma membrane, which could provide a new mechanism to explain the link between elevated levels of free fatty acids (FFAs), palmitate in particular, and macrophage death.

  9. The results indicate that RIP1 and MLKL contribute to necroptotic cell death after HCoV-OC43 infection to limit viral replication.

  10. this study reveals a unique response of Kupffer cells against liver ischemia reperfusion, that is, RIP1 (zeige RALBP1 Proteine)-dependent necrosis, which constitutes a novel mechanism of liver inflammatory immune activation in the pathogenesis of liver ischemia reperfusion injury

RIPK1 Protein Überblick

Protein Überblick

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Alternative names and synonyms associated with RIPK1

  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (LOC100230522)
  • inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ippk)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1)
  • RPA interacting protein (Rpain)
  • 2400006N03Rik Protein
  • C9orf12 Protein
  • D330015H01Rik Protein
  • RGD1311271 Protein
  • Rinp Protein
  • Rip Protein
  • Rip1 Protein
  • rIpk1 Protein
  • RP23-83I13.5 Protein

Bezeichner auf Proteinebene für RIPK1

receptor (TNFRSF)-interacting serine-threonine kinase 1 , 1,3,4,5,6-pentakisphosphate 2-kinase , inositol polyphosphate kinase 1 , inositol-1,3,4,5,6-pentakisphosphate 2-kinase , inositol-pentakisphosphate 2-kinase , ins(1,3,4,5,6)P5 2-kinase , insP5 2-kinase , RIP-1 , cell death protein RIP , receptor interacting protein , receptor-interacting protein 1 , receptor-interacting serine/threonine-protein kinase 1 , serine/threonine-protein kinase RIP , RPA interacting protein delta 2 , RPA interacting protein epsilon , RPA-interacting protein

100230522 Taeniopygia guttata
306808 Rattus norvegicus
8737 Homo sapiens
504727 Bos taurus
100524751 Sus scrofa
19766 Mus musculus
306886 Rattus norvegicus
69723 Mus musculus
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