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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN803887
Rush, Abel, Valadez, Pearson, Cooper: Activation of the Hedgehog pathway in pilocytic astrocytomas. in Neuro-oncology 2010
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Human EGF Protein expressed in Human - ABIN2452189
Cohen, Carpenter: Human epidermal growth factor: isolation and chemical and biological properties. in Proceedings of the National Academy of Sciences of the United States of America 1975
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2452188
Carpenter, Cohen: Epidermal growth factor. in The Journal of biological chemistry 1990
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN593405
An, Gip, Kim, Wu, Park, McVaugh, Schaffer, Bertozzi, Lebrilla: Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. in Molecular & cellular proteomics : MCP 2012
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN987821
Katagiri, Takahashi: Potential relationship between normalization of endometrial epidermal growth factor profile and restoration of fertility in repeat breeder cows. in Animal reproduction science 2006
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2215428
Zhou, Zhang, Jin, Chen, Wu, Li, Yue, Luo, Wang: Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR. in Biomedicine & pharmacotherapy 2013
Zebrafish scube1 (zeige SCUBE1 Proteine) (signal peptide-CUB (complement protein C1r (zeige C1R Proteine)/C1s (zeige C1S Proteine), Uegf, and Bmp1 (zeige BMP1 Proteine))-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis
EGF is likely a potential paracrine/juxtacrine factor from the oocytes to regulate the function of the follicle cells.
These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
EGF and TNFalpha (zeige TNF Proteine) cooperatively promoted the motility of HCC (zeige FAM126A Proteine) cells mainly through NF-kappaB (zeige NFKB1 Proteine)/p65 (zeige GORASP1 Proteine) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF and TNFalpha (zeige TNF Proteine) in promoting HCC (zeige FAM126A Proteine), and provide potential targets for HCC (zeige FAM126A Proteine) prevention and treatment.
Data suggest that EGF induces colorectal cancer cells to undergo epithelial-mesenchymal transition, enhances their ability to invade/migrate, and promotes phosphorylation of Ezrin (zeige EZR Proteine) at Tyr353. (EGF = epidermal growth factor)
Simulation results indicate that human epidermal growth factor receptor (zeige EGFR Proteine) (hEGFR) soluble soluble extracellular domains (sECD):EGF show different dynamic properties between the two pHs (zeige PCBD1 Proteine), and the complex may have a higher tendency of activation at pH 8.5.
EGF and IP-10 (zeige CXCL10 Proteine) were significantly elevated and GRO (zeige CXCL1 Proteine) levels were lower in the tear profile of HIV patients with dry eye disease (DED (zeige AATF Proteine)) compared to immunocompetent patients with DED (zeige AATF Proteine).
Data (including data from studies using transgenic/knockout mice) suggest that surfactant protein A1 (SPA1) interferes with EGF binding to EGFR (zeige EGFR Proteine) in pulmonary alveoli cell lines; SPA1 (zeige SIPA1 Proteine) directly binds extracellular domain of EGFR (zeige EGFR Proteine); binding of SPA1 (zeige SIPA1 Proteine) to EGFR (zeige EGFR Proteine) appears to be different from binding of SPD (zeige HOXD13 Proteine) to EGFR (zeige EGFR Proteine); binding of SPA1 (zeige SIPA1 Proteine) to EGFR (zeige EGFR Proteine) does not suppress EGF-induced phosphorylation of EGFR (zeige EGFR Proteine) or cell proliferation.
EGF-AREG (zeige AREG Proteine) interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium.
caspase-3 (zeige CASP3 Proteine) inhibitors also suppressed the attenuation of cell adhesion and phosphorylation of p38 MAPK (zeige MAPK14 Proteine) by EGF-F9. Our data indicated that EGF-F9 activated signals for apoptosis and induced de-adhesion in a caspase-3 (zeige CASP3 Proteine) dependent manner.
evidence that CDK1 (zeige CDK1 Proteine)/2 participate in the regulation of constitutive pre-mRNA splicing by EGF stimulation in MDA-MB-468 cells.
The EGF rs4444903 GG genotype is associated with higher susceptibility to HCV-related liver cirrhosis and hepatocellular carcinoma in the Chinese Han population
TGF-beta (zeige TGFB1 Proteine) opposes EGF-mediated sensitization to TRAIL-induced caspase-8 (zeige CASP8 Proteine) activation and apoptosis in non-transformed breast epithelial cells. EGF and TGF-beta (zeige TGFB1 Proteine) finely regulate sensitivity of human breast epithelial cells to TRAIL which may be relevant during morphogenesis.
hijacks miR (zeige MLXIP Proteine)-198/FSTL1 (zeige FSTL1 Proteine) wound-healing switch and steers a two-pronged pathway toward metastasis
These results indicate that Kindlin-1 (zeige FERMT1 Proteine) is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.
concentration of EGF is critical for the switch between hair follicle growth and inhibition, and EGF promotes DP cell proliferation via Notch (zeige NOTCH1 Proteine) signaling pathway
EGF promotes FoxM1 (zeige FOXM1 Proteine) expression through the ERK (zeige EPHB2 Proteine) signal pathway
Data indicate that Sonic hedgehog (Shh (zeige SHH Proteine)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Proteine)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Proteine) protein, epidermal growth factor (EGF) and receptors of the ErbB (zeige EGFR Proteine) receptors ErbB1 (zeige EGFR Proteine), ErbB2 (zeige ERBB2 Proteine) and ErbB3 (zeige ERBB3 Proteine).
Either LIF (zeige LIF Proteine) or EGF is needed during development of pre-implantation embryo.
PXR (zeige NR1I2 Proteine) activation stimulates EGF-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (zeige FOXO3 Proteine) from accelerating cell-cycle progression.
Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (zeige EGFR Proteine) signaling.
modulation of EGF signaling affects in vitro expansion and differentiation of progenitors from embryonic pancreas of both mice and man.
TLR4 (zeige TLR4 Proteine) blockade prevented TPN (zeige TAPBP Proteine)-associated intestinal mucosa atrophy by preserving proliferation and preventing apoptosis. This is driven by a reduction in TNF-alpha (zeige TNF Proteine) abundance and increased EGF.
Interval between litters and litter size may be linked with EGF polymorphisms in pigs.
10 nM/L EGF was the optimal dose for serum-free culture, which can replace traditional standard serum medium for in vitro expansion of miniature pig bone marrow-derived mesenchymal stem cells.
EGF coordinately activates multiple cell signaling pathways critical to proliferation, migration and survival of trophectoderm cells.
progesterone-induced TACE/ADAM17 (zeige ADAM17 Proteine) leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
The phase-related expression of EGF and EGFR (zeige EGFR Proteine) in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
EGF appears to sensitize epithelial cells to the detrimental effects of IFN-alpha (zeige IFNA Proteine) but also helps to restore barrier function in the healing phase.
analysis of EGF in dairy cows reveals increased EGF concentrations for 2-3 days between Days 2 and 5
Data suggest that EGF expression in endometrium varies by species and parity; in Japanese Black cows, EGF expression is consistently high, while in Holstein cows, EGF expression is down-regulated in postpartum period after second calving.
Data suggest that epidermal growth factor receptor (zeige EGFR Proteine) B [ErbB (zeige EGFR Proteine)] isoforms and their ligands (epidermal growth factor [EGF], amphiregulin (zeige AREG Proteine) [AREG (zeige AREG Proteine)], and neuregulin-1 (zeige NRG1 Proteine) [NRG1 (zeige NRG1 Proteine)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
EGF plays a role during bovine placentation.
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
epidermal growth factor (beta-urogastrone)
, pro-epidermal growth factor
, Pro-epidermal growth factor precursor (EGF)