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at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat
Data suggest that melanoma cells internalize/absorb cystatin C (zeige CST3 ELISA Kits) from culture media, leading to increased intracellular cystatin C (zeige CST3 ELISA Kits) levels; cystatin E/M (zeige CST6 ELISA Kits) is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M (zeige CST6 ELISA Kits) on down-regulation of legumain activity is pronounced.
AEP is activated and cleaves human alpha-synuclein (zeige SNCA ELISA Kits) at N103 in an age-dependent manner.
AEP promotes activation of the PI3K (zeige PIK3CA ELISA Kits)-AKT (zeige AKT1 ELISA Kits) signaling pathway in prostate cancer cells.
upregulation of legumain is associated with malignant behavior of uveal melanoma.
Studies indicate that legumain, usually in lysosomes, is also found extracellularly and even translocates to the cytosol and the nucleus.
legumain might play an important role in cervical cancer cell migration and invasion.
Legumain appears to be involved in tumor development and deterioration.
AEP acts as a delta-secretase, cleaving APP (zeige APP ELISA Kits) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (zeige APP ELISA Kits). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.
High legumain expression is associated with breast cancer.
This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.
legumain and TIMP-2 (zeige TIMP2 ELISA Kits) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy
This study showed that legumain may serve as a biomarker of disease, and that the occurrence of legumain-expressing macrophages in regions of acinar-to-ductal metaplasia suggests that this protease may influence reprogramming events that lead to inflammation-induced pancreatic cancer.
results suggest that legumain expression and activation and cleavage of annexin A2 (zeige ANXA2 ELISA Kits) are regulated by DJ-1 (zeige PARK7 ELISA Kits) through p53 (zeige TP53 ELISA Kits)
AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.
TDP-43 (zeige TARDBP ELISA Kits) is cleaved by AEP in brain.
TLR7 (zeige TLR7 ELISA Kits) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.
We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (zeige ICAM1 ELISA Kits)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (zeige RAC2 ELISA Kits)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (zeige PRKDC ELISA Kits) mice
AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (zeige EGFR ELISA Kits)
Immunohistochemical analyses revealed the expression of legumain in Iba1 (zeige AIF1 ELISA Kits)(+) microglial cells and glial fibrillary acidic protein (zeige GFAP ELISA Kits)-positive astrocytes of the peri (zeige POSTN ELISA Kits)-infarct area in mice after transient occlusion of the middle cerebral artery.
AEP has a pivotal role in the endosomal/lysosomal degradation system
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
, asparaginyl endopeptidase
, protease, cysteine 1
, protease, cysteine, 1 (legumain)
, cysteine protease 1
, protease, cysteine, 1