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Human SIRT1 ELISA Kit für Sandwich ELISA - ABIN420531
Kilic, Gok, Bacaksiz, Izmirli, Elibol-Can, Uysal: SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. in PLoS ONE 2014
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Rat (Rattus) SIRT1 ELISA Kit für Sandwich ELISA - ABIN434855
Rizk, El-Maraghy, Nassar: A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats. in PLoS ONE 2014
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Li, Feng, Xing, Wang, Du, Xu, Cao, Wang, Fan, Liu, Fan: Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. in International journal of molecular sciences 2014
Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
SIRT1 knock-out embryos display reduced Mat2a (zeige MAT2A ELISA Kits) expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
The present study demonstrates that the aging heart is characterized by contractile dysfunction associated with increased oxidative stress and endoplasmic reticulum stress and Sirtuin 1 might have the ability to protect the aging hearts from the inhibition of endoplasmic reticulum-mediated apoptosis.
SIRT1 has the ability to effectively regulate the wear particle-induced inflammatory responses, apoptosis, osteolysis in particle-stimulated osteoblasts and particle-induced osteolysis animal models.
Taken together, our data indicated that increased expression of miR (zeige MLXIP ELISA Kits)-181b potentially contributes to altered lipid metabolism in NAFLD (zeige TSC2 ELISA Kits). Downregulation of miR (zeige MLXIP ELISA Kits)-34a may be a therapeutic strategy against NAFLD (zeige TSC2 ELISA Kits) by regulating its target SIRT1.
data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain.
The Sirt7 (zeige SIRT7 ELISA Kits) mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (zeige DNMT1 ELISA Kits) and another member of the sirtuin family, Sirt1.
findings reveal an unexpected mechanism for SIRT3 (zeige SIRT3 ELISA Kits) regulation via SIRT1-mediated deacetylation. Improving mitochondrial SIRT3 (zeige SIRT3 ELISA Kits) functions by inhibiting SIRT3 (zeige SIRT3 ELISA Kits) acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.
THe data of this study supported that estrogen protects against ischemic stroke through preventing neuron death via the SIRT1-dependent AMPK (zeige PRKAA1 ELISA Kits) pathway
Models for post-menopausal and aging-related osteoporosis, respectively, show significant improvements in bone mass upon treatment with SIRT1 agonist, SRT1720. SIRT1 whole-body knockout (KO) mice, as well as osteoblast and osteoclast specific KOs, show a low bone mass phenotype. Results suggest that SIRT1 acts as a positive regulator of in vivo bone mass.
Genistein increases SIRT1 expression in renal cells after renal ischemia/reperfusion induced injury. These data indicate that SIRT1 may contribute to the protective effects of genistein on tubular damage and the loss of renal function in ischemia/reperfusion injury.
Association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.
The results suggested that inhibition of glycolysis using sub-lethal doses of 2-DG down-regulated the expression of VEGF (zeige VEGFA ELISA Kits) and also significantly reduced its biological activity. Further mechanistic studies revealed that the down regulation of VEGF (zeige VEGFA ELISA Kits) gene expression by 2-DG was due to an increase in SIRT-1 activity
The present results suggest that resveratrol and EPA, but not DHA, markedly activated the SIRT1 gene expression in THP1 (zeige GLI2 ELISA Kits) cells, and that high glucose medium could inhibit the basic gene expression, but not powerful resveratrol-induced gene expression, in those cells.
Accordingly, our results demonstrated that NAMPT (zeige NAMPT ELISA Kits) is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2 (zeige E2F2 ELISA Kits)-SIRT1 pathway establishes another link between NAMPT (zeige NAMPT ELISA Kits) and apoptosis events in melanoma, with therapeutic implications for this deadly cancer.
These data suggest that SIRT1 activates HBG expression through facilitating LCR looping to the HBG promoter, inhibiting the expression of transcriptional suppressors of HBG, and indirectly increasing histone acetylation in the HBG promoter.
Levels of miR106a are modulated during cellular migration, causing a change in the levels of SIRT-1 mRNA by affecting its stability and the levels of SIRT-1 in turn can regulate the levels of MMP9 (zeige MMP9 ELISA Kits).
Study demonstrated a functional role of the SIRT1/miR (zeige MLXIP ELISA Kits)-15b-5p/ACOX1 (zeige ACOX1 ELISA Kits) axis in CRC (zeige CALR ELISA Kits) metastasis.
These studies suggest SIRT1/PGC-1alpha (zeige PPARGC1A ELISA Kits) as underlying pathways contributing to AMD (zeige AMD1 ELISA Kits) pathophysiology.
SIRT1 protected LECs from oxidative stress via the inhibition of the p53 (zeige TP53 ELISA Kits) pathway. SIRT1 or SIRT1 activators could potentially be used to prevent ocular aging and cataract in the future.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (zeige TP53 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 ELISA Kits)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (zeige PPARG ELISA Kits) to that of ATGL (zeige PNPLA2 ELISA Kits) in adipocytes.
CDK5 (zeige CDK5 ELISA Kits)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (zeige STK11 ELISA Kits)/AMPK (zeige PRKAA1 ELISA Kits) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (zeige FOXO1 ELISA Kits).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (zeige MYLIP ELISA Kits)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (zeige FABP3 ELISA Kits) gene in adipocytes, and PPAR gamma (zeige PPARG ELISA Kits) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (zeige FOXO1 ELISA Kits) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (zeige SIRT3 ELISA Kits) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1