anti-PAK1 (PAK1) Antikörper

anti-P21-Activated Kinase 1 Antikörper (PAK1)
Auf finden Sie aktuell 344 P21-Activated Kinase 1 (PAK1) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PAK1 Proteine (19) und PAK1 Kits (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 391 PAK1 Produkte verfügbar.
AW045634, pak, PAK-1, Paka, PAKalpha, X-PAK1, XPak1

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Am meisten referenzierte anti-PAK1 Antikörper

  1. Human Polyclonal PAK1 Primary Antibody für EIA - ABIN358352 : Li, Guan: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 5 Referenzen für 358352

  2. Human Polyclonal PAK1 Primary Antibody für EIA - ABIN358296 : DerMardirossian, Schnelzer, Bokoch: Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. in Molecular cell 2004 (PubMed)
    Zeige alle 5 Referenzen für 358296

  3. Human Polyclonal PAK1 Primary Antibody für IF, IHC (p) - ABIN197378 : Parsons, Monypenny, Ameer-Beg, Millard, Machesky, Peter, Keppler, Schiavo, Watson, Chernoff, Zicha, Vojnovic, Ng: Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. in Molecular and cellular biology 2005 (PubMed)
    Zeige alle 4 Referenzen für 197378

  4. Human Polyclonal PAK1 Primary Antibody für IF, IHC (p) - ABIN196896 : Jung, Traugh: Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 4 Referenzen für 196896

  5. Human Polyclonal PAK1 Primary Antibody für WB - ABIN1944750 : Brown, Stowers, Baer, Trejo, Coughlin, Chant: Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. in Current biology : CB 1997 (PubMed)
    Zeige alle 3 Referenzen für 1944750

  6. Human Polyclonal PAK1 Primary Antibody für EIA, IHC (p) - ABIN360317 : Chen, Yin, Zhu, Yan, Ji, Chen, Cai, Zhang, Zong, Hu, Yuan, Shen, Gu: The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 3 Referenzen für 360317

  7. Human Polyclonal PAK1 Primary Antibody für ELISA, WB - ABIN188561 : Zhao, Ma, Calon, Harris-White, Yang, Lim, Morihara, Ubeda, Ambegaokar, Hansen, Weisbart, Teter, Frautschy, Cole: Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. in Nature neuroscience 2006 (PubMed)

  8. Human Polyclonal PAK1 Primary Antibody für DB, IF - ABIN389799 : El-Baba, Mahadevan, Fahlbusch, S, Rau, Gali-Muhtasib, Schneider-Stock: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. in Molecular cancer 2014 (PubMed)

Weitere Antikörper gegen PAK1 Interaktionspartner

Xenopus laevis P21-Activated Kinase 1 (PAK1) Interaktionspartner

  1. results represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification

  2. These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 activity in cancer cells.

  3. The data suggest that EphA4 activation sequesters active Cdc42 (zeige CDC42 Antikörper) and in this way down-regulates cell-cell adhesion.

  4. Pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.

Human P21-Activated Kinase 1 (PAK1) Interaktionspartner

  1. this study shows that PAK1 may be a potential tumor marker and therapeutic target of prostate cancer

  2. Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 could be a potential therapeutic target and of great clinical relevance with implications for Runx3 (zeige RUNX3 Antikörper) inactivation in cancer cells where Runx3 (zeige RUNX3 Antikörper) is known to be oncogenic. The findings presented in this study provide evidence of Runx3 (zeige RUNX3 Antikörper)-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions

  3. Abnormalities in the PAK1 and PAK3 mRNA levels as well as their altered coexpression patterns were observed in the postmortem brain of subjects with depression. Dysregulated PAK1/PAK3 dependent signaling may be a key factor responsible for volumetric abnormalities observed in the hippocampus and in the prefrontal cortex in depression resulting in altered connectivity of these regions.

  4. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ (zeige RHOJ Antikörper) signaling halts the growth of BRAF (zeige BRAF Antikörper) mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism

  5. these data strongly support a critical interplay between prolactin (zeige PRL Antikörper) and estrogen via PAK1 and suggest that ligand-independent activation of ERalpha (zeige ESR1 Antikörper) through prolactin (zeige PRL Antikörper)/PAK1 may impart resistance to anti-estrogen therapies.

  6. Given the central role of p21-Activated kinase 1 (PAK1) in vital signaling pathways, studies suggest that clinical development of PAK1 inhibitors will require careful investigation of their safety and efficacy.

  7. These findings suggest that small-molecule inhibitors of Pak1 may have a therapeutic role in the ~25% of ovarian cancers characterized by PAK1 gene amplification.

  8. autocrine VEGF (zeige VEGFA Antikörper) and IL-8 (zeige IL8 Antikörper) promoted endothelial cell migration via the Src (zeige SRC Antikörper)/Vav2 (zeige VAV2 Antikörper)/Rac1/PAK1 signaling pathway.

  9. These data provide insight into the mechanisms guiding PRL (zeige PRL Antikörper)-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 in breast cancer metastasis.

  10. p120 (zeige HNRNPU Antikörper) participates in the progress of gastric cancer through regulating Rac1 and Pak1.

Mouse (Murine) P21-Activated Kinase 1 (PAK1) Interaktionspartner

  1. The findings suggest that PAK1 deficiency may underlie an increased diabetic susceptibility. Discovery of ways to remediate glycaemic dysregulation via altering PAK1 or its downstream effectors offers promising opportunities for disease intervention.

  2. present work presents the correlation between DSCAM gene overexpression and a dysregulation of the PAK pathway, resulting in altered morphological parameters of neuronal plasticity in the trisomic cell line, namely decreased number and length of processes

  3. These results identify Pak1 and Pak2 (zeige PAK2 Antikörper) as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (zeige CDH2 Antikörper)/Cdo (zeige CDO1 Antikörper)/Cdc42 (zeige CDC42 Antikörper) signaling pathway.

  4. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  5. These results implicate PAK1 as a regulator of Pancreatic stellate cells activation, proliferation and apoptosis. Targeting stromal PAK1 could increase therapeutic response and survival of patients with pancreatic cancer.

  6. The authors conclude that PAK1, besides its role in virus entry, also plays a relevant role in vaccinia virus dissemination.

  7. PAK1 contributes to initiation of intestinal carcinogenesis

  8. Pak1 is essential for adaptive physiological exercise-induced cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival.

  9. Further investigations identified Pak1-ERM (zeige ETV5 Antikörper) as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK (zeige MAPK14 Antikörper) signaling ensures timely epithelial apoptotic death at postimplantation.

  10. Nischarin (zeige NISCH Antikörper) inhibits neurite outgrowth by blocking PAK1 activation in neurons.

Caenorhabditis elegans (C. elegans) P21-Activated Kinase 1 (PAK1) Interaktionspartner

  1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.

  2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.

  3. Pak-1 interacts with Wnt (zeige WNT2 Antikörper) signaling to regulate tissue polarity and gene expression.

  4. only PAK-1 functions in the GIT/PIX (zeige ARHGEF7 Antikörper)/PAK pathway independently of RAC (zeige AKT1 Antikörper)/CDC42 (zeige CDC42 Antikörper) GTPases.

  5. Data show that combined loss of ROCK and PAK, or ROCK and MRCK (zeige CDC42BPA Antikörper), completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK (zeige CDC42BPA Antikörper).

PAK1 Antigen-Profil

Beschreibung des Gens

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PAK1

  • p21 protein (Cdc42/Rac)-activated kinase 1 (pak1) Antikörper
  • p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) Antikörper
  • p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1) Antikörper
  • Protein PAK-1 (pak-1) Antikörper
  • AW045634 Antikörper
  • pak Antikörper
  • PAK-1 Antikörper
  • Paka Antikörper
  • PAKalpha Antikörper
  • X-PAK1 Antikörper
  • XPak1 Antikörper

Bezeichner auf Proteinebene für PAK1

p21 GTPase-associated kinase 1 , p21-activated kinase 1 , p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) , putative CDKN1A-activated kinase 1 , STE20 homolog, yeast , alpha-PAK , p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) , p65-PAK , serine/threonine-protein kinase PAK 1 , CDC42/RAC effector kinase PAK-A , activated protein kinase alpha , PAK-1 , p21 (CDKN1A)-activated kinase 1 , p68-PAK , protein kinase MUK2

398126 Xenopus laevis
451439 Pan troglodytes
100190755 Taeniopygia guttata
5058 Homo sapiens
18479 Mus musculus
29431 Rattus norvegicus
607885 Canis lupus familiaris
533729 Bos taurus
180873 Caenorhabditis elegans
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