MAP2K7 Proteine (MAP2K7)

Mitogen-Activated Protein Kinase Kinase 7 Proteine (MAP2K7)
Auf finden Sie aktuell 13 Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP2K7 Antikörper (147) und MAP2K7 Kits (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 186 MAP2K7 Produkte verfügbar.
2, 5930412N11Rik, JNKK, JNKK 2, Jnkk2, MAP2K7, map2k7-A, MAPKK7, MAPKK 7, Mek7, MEK 7, MKK7, Prkmk7, SAPKK-4, SAPKK4, sek2, si:ch211-254d18.2
alle Proteine anzeigen Gen GeneID UniProt
MAP2K7 363855 Q4KSH7
MAP2K7 5609 O14733
MAP2K7 26400 Q8CE90

Weitere Synonyme anzeigen

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Weitere Proteine zu MAP2K7 Interaktionspartnern

Human Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) Interaktionspartner

  1. MEK activation cooperates with Cdkn2a and Pten inactivation to induce melanoma

  2. MKK7 undergoes neddylation in human breast cancer cells

  3. In an Eastern Chinese population, carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC.

  4. Therefore, EGF (zeige EGF Proteine) is suggested to induce E-cadherin (zeige CDH1 Proteine) down-regulation at the transcriptional level through the MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.

  5. combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers

  6. our study suggested that black rice anthocyanins extract suppress metastasis in breast cancer cells by targeting the RAS/RAF (zeige RAF1 Proteine)/MAPK (zeige MAPK1 Proteine) pathway

  7. Crystal structures of the wild type and C218S mutant of MAP2K7 were determined. Cys218 plays a crucial role in configuring an auto-inhibition form of MAP2K7.

  8. We found that the MKK7 p.Glu116Lys rare polymorphism was significantly associated with lung cancer risk, progression and prognosis

  9. we explored the effects of selumetinib in combination with gefitinib in a panel of TNBC cells, in order to evaluate whether the simultaneous blockade of the EGFR (zeige EGFR Proteine) and the RAS/MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) pathway might increase the antitumor activity of selumetinib in TNBC.

  10. a widespread role for the JNK (zeige MAPK8 Proteine)-CELF2 (zeige CELF2 Proteine) axis in controlling splicing during T-cell activation, including a specific role in propagating JNK (zeige MAPK8 Proteine) signaling.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) Interaktionspartner

  1. The loss of mkk4 (zeige MAP2K4 Proteine) and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.

  2. Arrestin-3 (zeige ARRB2 Proteine) directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 (zeige MAP2K4 Proteine) and MKK7 in vitro as well as in intact cells.

  3. MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b (zeige MAP1B Proteine) phosphorylation to regulate microtubule bundling leading to neurite elongation.

  4. Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.

  5. a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.

  6. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.

  7. MKK4 (zeige MAP2K4 Proteine)/7 and JNK1 (zeige MAPK8 Proteine)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.

  8. This study demonistrated that Stress-activated protein kinase (zeige CDK7 Proteine) MKK7 regulates axon elongation in the developing cerebral cortex.

  9. The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.

  10. The role of NF-kappaB (zeige NFKB1 Proteine) and c-jun N-terminal kinase (JNK) activation in RANKL (zeige TNFSF11 Proteine)-induced osteoclast differentiation was investigated using an adenovirus vector carrying the dominant negative 1kappaB kinase 2 gene or dominant negative MKK7 gene.

MAP2K7 Protein Überblick

Protein Überblick

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Alternative names and synonyms associated with MAP2K7

  • mitogen-activated protein kinase kinase 7 (MAP2K7)
  • mitogen activated protein kinase kinase 7 (Map2k7)
  • mitogen-activated protein kinase kinase 7 (Map2k7)
  • mitogen-activated protein kinase kinase 7 (map2k7)
  • 2 Protein
  • 5930412N11Rik Protein
  • JNKK Protein
  • JNKK 2 Protein
  • Jnkk2 Protein
  • MAP2K7 Protein
  • map2k7-A Protein
  • MAPKK7 Protein
  • MAPKK 7 Protein
  • Mek7 Protein
  • MEK 7 Protein
  • MKK7 Protein
  • Prkmk7 Protein
  • SAPKK-4 Protein
  • SAPKK4 Protein
  • sek2 Protein
  • si:ch211-254d18.2 Protein

Bezeichner auf Proteinebene für MAP2K7

mitogen-activated protein kinase kinase 7 , JNK kinase 2 , JNK-activating kinase 2 , JNKK 2 , MAP kinase kinase 7 , MAPK/ERK kinase 7 , MAPKK 7 , MEK 7 , c-Jun N-terminal kinase kinase 2 , dual specificity mitogen-activated protein kinase kinase 7 , SAPK kinase 4 , stress-activated protein kinase kinase 4 , mitogen activated protein kinase kinase 7 , protein kinase, mitogen activated, kinase 7

787278 Bos taurus
100302082 Ovis aries
363855 Rattus norvegicus
5609 Homo sapiens
485004 Canis lupus familiaris
26400 Mus musculus
560913 Danio rerio
394391 Xenopus laevis
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