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High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (zeige ICAM1 ELISA Kits)), ezrin (EZR (zeige EZR ELISA Kits)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (zeige NOS ELISA Kits) 3 (NOS3) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (zeige PTPN11 ELISA Kits)) syndrome
Data show that mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) kinases MEK1 (zeige MAP2K1 ELISA Kits)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (zeige MAPK1 ELISA Kits) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (zeige MAP2K1 ELISA Kits)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (zeige MAP2K1 ELISA Kits)/2
Endocytosis separates EGF (zeige EGF ELISA Kits) receptors from endogenous fluorescently labeled HRas (zeige HRAS ELISA Kits) and diminishes receptor signaling to MAP kinases in endosomes.
MEK1 (zeige MAP2K1 ELISA Kits) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.
MEK1/2 inhibitor trametinib showed similar PFS and a response rate as docetaxel in patients with previously treated KRAS-mutant-positive non-small cell lung carcinoma.
We report on a fourth familial case with transmission of CFC (zeige PTPN11 ELISA Kits) syndrome from father to son due to a novel heterozygous sequence change c.376A>G (p.N126D) in exon 3 of MEK2 gene.
fluid shear stress induces autocrine TGF-beta (zeige TGFB1 ELISA Kits)/ALK5 (zeige TGFBR1 ELISA Kits)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (zeige MAP2K1 ELISA Kits)/2-mediated signaling.
FGF2 (zeige FGF2 ELISA Kits) is an extracellular inducer of COUP-TFII (zeige NR2F2 ELISA Kits) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 ELISA Kits) expression prior to the onset of osteogenic differentiation
REDD1 (zeige DDIT4 ELISA Kits) is required for normal insulin (zeige INS ELISA Kits)-stimulated signaling, and a subtle balance exists between MEK1 (zeige MAP2K1 ELISA Kits)/2, REDD1 (zeige DDIT4 ELISA Kits), and mTOR (zeige FRAP1 ELISA Kits)
MEK1 (zeige MAP2K1 ELISA Kits) and MEK2 can substitute for each other but a minimum amount of MEK (zeige MDK ELISA Kits) is critical for placenta development and embryo survival
MK2 (zeige KCNA2 ELISA Kits)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (zeige KCNA2 ELISA Kits) attenuates dendritic cell-mediated Th1 (zeige HAND1 ELISA Kits) differentiation and autoimmune encephalomyelitis.
analysis of p38 (zeige CRK ELISA Kits)-MK2 (zeige KCNA2 ELISA Kits)-activated Rsk (zeige RPS6KA1 ELISA Kits) signaling in toll (zeige TLR4 ELISA Kits)-like receptor-stimulated dendritic cells
both MEK1 (zeige MAP2K1 ELISA Kits) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
MK2 (zeige KCNA2 ELISA Kits) is responsible for resistance of p53 (zeige TP53 ELISA Kits)-deficient tumors to cisplatin
MK2 (zeige KCNA2 ELISA Kits) plays a critical role in the development of apoptosis.
the AtMKK2-AtMPK10 (zeige MAPK10 ELISA Kits) MAPK (zeige MAPK1 ELISA Kits) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (zeige MAPK4 ELISA Kits) activation concomitantly with MEKK1 (zeige MAP3K1 ELISA Kits) and MKK2 phosphorylation.
Ca(2 (zeige CA2 ELISA Kits)+) signaling occurred upstream of the MEKK1 (zeige MAP3K1 ELISA Kits)-MKK2 pathway. MEKK1 (zeige MAP3K1 ELISA Kits) was phosphorylated by calcium/calmodulin (zeige CALM ELISA Kits)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (zeige MAP3K1 ELISA Kits).
Data indicate that MEKK2 (zeige MAP3K2 ELISA Kits) is required for the mekk1 (zeige MAP3K1 ELISA Kits), mkk1 (zeige MAP2K1 ELISA Kits) mkk2, and mpk4 (zeige MAPK4 ELISA Kits) autoimmune phenotypes.
Data suggest that the MEKK1 (zeige MAP3K1 ELISA Kits)-MKK1 (zeige MAP2K1 ELISA Kits)/MKK2-MPK4 (zeige MAPK4 ELISA Kits) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 ELISA Kits) and activation of MEKK2 (zeige MAP3K2 ELISA Kits) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (zeige MAP2K1 ELISA Kits)/2) of MKK1 (zeige MAP2K1 ELISA Kits) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (zeige MAPK4 ELISA Kits) by flg22 is impaired in the mkk1 (zeige MAP2K1 ELISA Kits) mkk2 double mutants, suggesting that MKK1 (zeige MAP2K1 ELISA Kits) and MKK2 function together with MPK4 (zeige MAPK4 ELISA Kits) and MEKK1 (zeige MAP3K1 ELISA Kits) in a MAP kinase (zeige MAPK1 ELISA Kits) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2