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This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (zeige MAP3K1 ELISA Kits)-p38 (zeige MAPK14 ELISA Kits), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
this study demonstrates that CPEB2 (zeige CPEB2 ELISA Kits) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
Noxin (zeige C11orf82 ELISA Kits) facilitated the expression of Cyclin D1 (zeige CCND1 ELISA Kits) and Cyclin E1 (zeige CCNE1 ELISA Kits) through activating P38 (zeige CRK ELISA Kits)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
In SOD1 (zeige SOD1 ELISA Kits)(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha (zeige TNF ELISA Kits), TNFR1 (zeige TNFRSF1A ELISA Kits) and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 (zeige TNFRSF1A ELISA Kits) completely abolished GDNF rises in both SOD1 (zeige SOD1 ELISA Kits)(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration (zeige CLN8 ELISA Kits) and disease progression
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
these observations suggest that CD99 (zeige CD99 ELISA Kits) is involved in the regulation of CD1a (zeige CD1A ELISA Kits) transcription and expression by increasing ATF-2.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (zeige TNF ELISA Kits) induces the binding of ATF2 to the TNF (zeige TNF ELISA Kits)-responsive element.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
adiponectin (zeige ADIPOQ ELISA Kits) inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (zeige PRKAA1 ELISA Kits)/PPARalpha (zeige PPARA ELISA Kits)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (zeige MAPK14 ELISA Kits), AAT, signal transducer and activator of transcription 1 (STAT1 (zeige STAT1 ELISA Kits)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (zeige PRKCE ELISA Kits) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (zeige FUK ELISA Kits) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (zeige MAPK8 ELISA Kits) requires ATF2.
Taken together, our observations indicated that SOCS2 (zeige SOCS2 ELISA Kits) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (zeige MAPK14 ELISA Kits) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (zeige ATF3 ELISA Kits) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (zeige TH ELISA Kits) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (zeige IL1B ELISA Kits)-induced increase in intestinal tight junction permeability was regulated by p38 (zeige CRK ELISA Kits) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (zeige MYLK ELISA Kits) gene activity
The ATF2 represses renin (zeige REN ELISA Kits) expression by drifting the transcriptional control of renin (zeige REN ELISA Kits) gene away from CRE-binding protein (CREB (zeige CREB1 ELISA Kits)).
ATF2-based luciferase reporter to monitor non-canonical Wnt (zeige WNT2 ELISA Kits) signaling in Xenopus embryos.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (zeige UTS2R ELISA Kits) of ATF1 (zeige AFT1 ELISA Kits)/2, and indicates a difference between short and long isoforms.
Ang II (zeige AGT ELISA Kits) increases endothelial arginase activity/expression through a p38 MAPK (zeige MAPK14 ELISA Kits)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (zeige GRIN2A ELISA Kits) protein kinase D (zeige PRKD1 ELISA Kits) mutant increased AngII-induced CREB (zeige CREB1 ELISA Kits) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (zeige CREB1 ELISA Kits) binding to the steroidogenic acute regulatory protein (zeige STAR ELISA Kits) promoter.
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
chimerin (chimaerin) 1
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, cyclic AMP response element binding protein 2
, astrocyte-derived trophic factor
, glial cell line-derived neurotrophic factor