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anti-PPP1R12A (PPP1R12A) Antikörper

anti-Myosin Phosphatase, Target Subunit 1 Antikörper (PPP1R12A)
Auf finden Sie aktuell 96 Myosin Phosphatase, Target Subunit 1 (PPP1R12A) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PPP1R12A Kits (6) und PPP1R12A Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 115 PPP1R12A Produkte verfügbar.
1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, M110, M130, MBS, MBSP, MYPT1
Alle Antikörper anzeigen Gen GeneID UniProt
PPP1R12A 17931 Q9DBR7
PPP1R12A 4659 O14974
PPP1R12A 116670 Q10728

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Meistgesuchte Reaktivitäten zu anti-PPP1R12A (PPP1R12A) Antikörper

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anti-Mouse (Murine) PPP1R12A Antikörper:

anti-Human PPP1R12A Antikörper:

anti-Rat (Rattus) PPP1R12A Antikörper:

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Am meisten referenzierte anti-PPP1R12A Antikörper

  1. Human Monoclonal PPP1R12A Primary Antibody für WB - ABIN968767 : Chen, Chen, Alessi, Campbell, Shanahan, Cohen, Cohen: Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. in FEBS letters 1995 (PubMed)
    Zeige alle 3 Referenzen für ABIN968767

Weitere Antikörper gegen PPP1R12A Interaktionspartner

Mouse (Murine) Myosin Phosphatase, Target Subunit 1 (PPP1R12A) Interaktionspartner

  1. Mypt1 E24 splice variants tune arterial reactivity and could be worthy targets for lowering vascular resistance in disease states.

  2. revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice

  3. phosphorylation of MYPT1 T694, but not T852, mediates force maintenance in bladder smooth muscle.

  4. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle

  5. Maturation of mesenteric artery smooth muscle involves TRA2beta (zeige TRA2B Antikörper) mediated Mypt1 exon 24 splicing.

  6. The role of MYPT1 in vascular smooth muscle was investigated in adult MYPT1 smooth muscle specific knock-out mice. MYPT1 deletion enhanced phosphorylation of myosin regulatory light chain and contractile force in isolated mesenteric arteries.

  7. MYPT1 is not essential for smooth muscle function in mice but regulates the Ca(2 (zeige CA2 Antikörper)+) sensitivity of force development and contributes to intestinal phasic contractile phenotype.

  8. Tra2beta (zeige TRA2B Antikörper), by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.

  9. Organ-specific mechanisms involving MYPT1, M-RIP (zeige MPRIP Antikörper), and CPI-17 (zeige PPP1R14A Antikörper) are critical to regulating basal LC20 (zeige MYL9 Antikörper) phosphorylation in gastrointestinal smooth muscles.

  10. Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated (zeige NSDHL Antikörper) muscle adaptations through SMTNL1 and MYPT1.

Human Myosin Phosphatase, Target Subunit 1 (PPP1R12A) Interaktionspartner

  1. Study revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice.

  2. These results indicate that PPP1R12A indeed plays a role in skeletal muscle insulin (zeige INS Antikörper) signaling

  3. the relative expression of LZ+/LZ (zeige LYZ Antikörper)- MYPT1 isoforms, in part, defines the vascular response to NO and NO based vasodilators, and therefore, plays a role in the regulation of vascular tone in both health and disease

  4. Expression of NUAK1 (zeige NUAK1 Antikörper) is controlled by cyclin-dependent kinase (zeige CDK1 Antikörper), PLK1 (zeige PLK1 Antikörper), and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (zeige MUL1 Antikörper) complex.

  5. distinct roles of two inhibitory phosphorylation sites of MYPT1

  6. in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 is cleaved by caspase-3, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding

  7. results suggested that during atherosclerosis progression oxidative stress mediates the downregulation of MYPT1, which may inhibit smooth muscle cell migration and contribute to the aberrant contractility

  8. Calcineurin (zeige PPP3CA Antikörper) may modulate the phosphorylation level of MLC20 (zeige MYL12B Antikörper) by influencing the phosphorylation state of MYPT1 to regulate endothelial barrier function.

  9. Mypt1 colocalizes outside the nucleus with Nkx2.5 in a manner dependent on Wnt signaling and Rho-associated protein kinase.

  10. These findings provide evidence for the involvement of a particular PP1 (zeige PPA1 Antikörper) complex, PPP1R12A/PP1cdelta, in insulin (zeige INS Antikörper) signaling.

PPP1R12A Antigen-Profil

Beschreibung des Gens

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PPP1R12A

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) Antikörper
  • protein phosphatase 1, regulatory subunit 12A (PPP1R12A) Antikörper
  • protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) Antikörper
  • 1200015F06Rik Antikörper
  • 5730577I22Rik Antikörper
  • AA792106 Antikörper
  • AV099298 Antikörper
  • D10Ertd625e Antikörper
  • M110 Antikörper
  • M130 Antikörper
  • MBS Antikörper
  • MBSP Antikörper
  • MYPT1 Antikörper

Bezeichner auf Proteinebene für PPP1R12A

myosin phosphatase target subunit 1 , myosin phosphatase, target subunit 1 , myosin phosphatase-targeting subunit 1 , protein phosphatase 1 regulatory subunit 12A , myosin binding subunit , protein phosphatase 1, regulatory (inhibitor) subunit 12A , protein phosphatase myosin-binding subunit , PP-1M , protein phosphatase subunit 1M , serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110 , smooth muscle myosin phosphatase myosin-binding subunit , 130 kDa myosin-binding subunit of smooth muscle myosin phophatase , 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase , 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133) , PP1M subunit M110

17931 Mus musculus
4659 Homo sapiens
116670 Rattus norvegicus
396020 Gallus gallus
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