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anti-Human MSH5 Antikörper:
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Human Monoclonal MSH5 Primary Antibody für IF, ELISA - ABIN518027
Akimoto, Kitagawa, Matsumoto, Kato: Spermatogenesis-specific association of SMCY and MSH5. in Genes to cells : devoted to molecular & cellular mechanisms 2008
Human Polyclonal MSH5 Primary Antibody für IHC (p), IHC - ABIN451690
Neyton, Lespinasse, Lahaye, Staccini, Paquis-Flucklinger, Santucci-Darmanin: CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization. in Experimental cell research 2007
Findings indicate that carriers of the MSH5 rs707939 T allele, the MSH2 (zeige MSH2 Antikörper) rs6544991 C allele, the MSH3 (zeige MSH3 Antikörper) rs6151627 and rs6151670 G alleles, and the MSH3 (zeige MSH3 Antikörper) rs7709909 T allele have poor toxicity tolerance to platinum-based chemotherapy in non-small cell lung cancer patients.
From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence
our data point to the existence of a functional interplay between hMSH5 and FANCJ (zeige BRIP1 Antikörper) in double-strand break repair induced by replication stress.
the roles of hMSH5 variants in the processes of DNA damage response and repair
Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells.
Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin.
The presence of the MSH5 85F allele marks the subgroup of DRB1 (zeige RBM45 Antikörper)*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors.
hMSH5 possesses a CRM1 (zeige XPO1 Antikörper)-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting.
There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 (zeige MLH3 Antikörper) with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 (zeige MLH3 Antikörper) polymorphisms increased the risk of developing male infertility
The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene.
These findings suggest that Msh4 (zeige MSH4 Antikörper)/5 heterodimers contribute to class switch recombination.
Immunohistochemical analysis revealed the co-localization of SMCY (zeige KDM5D Antikörper) with MSH5 (zeige HSPA1L Antikörper) at a specific stage of meiotic prophase progression during murine spermatogenesis.
Results reported in this study indicate that Msh5 (zeige HSPA1L Antikörper) does not have a role in immunoglobulin class switch recombination.
Results report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process that results in an increase in MSH-5 protein levels.
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
mutS homolog 5 (E. coli)
, mutS homolog 5-like
, mutS protein homolog 5-like
, mutS homolog 5
, mutS protein homolog 5
, mutS-like protein 5
, DNA mismatch repair protein Msh5