anti-CDK5RAP2 (CDK5RAP2) Antikörper

Bezeichnung:
anti-CDK5 Regulatory Subunit Associated Protein 2 Antikörper (CDK5RAP2)
Auf www.antikoerper-online.de finden Sie aktuell 30 CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Antikörper von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK5RAP2 Kits (1) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 32 CDK5RAP2 Produkte verfügbar.
Synonyme:
2900018K03Rik, an, C48, Cep215, EGFL5, MCPH3, mKIAA1633
Alle Antikörper anzeigen Gen GeneID UniProt
CDK5RAP2 55755 Q96SN8
CDK5RAP2 214444 Q8K389
CDK5RAP2 286919  

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Meistgesuchte Reaktivitäten zu anti-CDK5RAP2 (CDK5RAP2) Antikörper

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anti-Human CDK5RAP2 Antikörper:

anti-Mouse (Murine) CDK5RAP2 Antikörper:

anti-Rat (Rattus) CDK5RAP2 Antikörper:

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Am meisten referenzierte anti-CDK5RAP2 Antikörper

  1. Human Polyclonal CDK5RAP2 Primary Antibody für IP, WB - ABIN152186 : Lizarraga, Margossian, Harris, Campagna, Han, Blevins, Mudbhary, Barker, Walsh, Fleming: Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. in Development (Cambridge, England) 2010 (PubMed)
    Zeige alle 4 Referenzen für 152186

  2. Human Polyclonal CDK5RAP2 Primary Antibody für IHC, ELISA - ABIN1534333 : Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004 (PubMed)

Weitere Antikörper gegen CDK5RAP2 Interaktionspartner

Human CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Interaktionspartner

  1. results suggest that EB1 (zeige MAPRE2 Antikörper) cooperates with CDK5RAP2 and perhaps other SXIP-containing +TIPs in tracking growing microtubule tips.

  2. CDK5RAP2 may play a role in primary microcephaly and interacts with components of the Hippo signaling pathway

  3. Three siblings with isolated agenesis of corpus callosum carry compound heterozygous variants, p.[Gly94Arg];[Asn1232Ser], in CDK5RAP2 gene.

  4. stabilization of the centrosome-spindle pole interface by the CEP215-HSET (zeige KIFC1 Antikörper) complex could promote survival of cancer cells containing supernumerary centrosomes.

  5. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  6. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.

  7. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM (zeige PCMT1 Antikörper)) preventing centriole separation following disengagement, PCNT (zeige PCNT Antikörper) cleavage mediates Cep215 removal from core of the PCM (zeige PCMT1 Antikörper) to inhibit centriole disengagement and duplication

  8. LRRK1 regulates mitotic spindle orientation downstream of PLK1 (zeige PLK1 Antikörper) through CDK5RAP2-dependent centrosome maturation.

  9. The CEP215-pericentrin (zeige PCNT Antikörper) interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.

  10. DPP4, CDK5RAP2, and CCR6 are risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Interaktionspartner

  1. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  2. this study revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice.

  3. In Cdk5rap2-depleted neural embryonic stem cells there is an increase in cell death in differentiating cells.

  4. Mouse expression pattern of CDK5RAP2 is similar to that seen in humans and is in concordance with pathology suggested by neuroimaging studies in humans and mouse

  5. This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A (zeige AURKA Antikörper).

  6. These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication.

  7. Cdk5rap2 is highly expressed in the neural progenitor pool and its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation

  8. The an mutation is a genomic inversion of exon 4 of Cdk5rap2, resulting in an in-frame deletion of exon 4 from the mRNA. Cdk5rap2(an/an) neuronal precursors exit the cell cycle prematurely and many undergo apoptosis.

CDK5RAP2 Antigen-Profil

Beschreibung des Gens

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CDK5RAP2

  • CDK5 regulatory subunit associated protein 2 (CDK5RAP2) Antikörper
  • CDK5 regulatory subunit associated protein 2 (cdk5rap2) Antikörper
  • CDK5 regulatory subunit associated protein 2 (Cdk5rap2) Antikörper
  • 2900018K03Rik Antikörper
  • an Antikörper
  • C48 Antikörper
  • Cep215 Antikörper
  • EGFL5 Antikörper
  • MCPH3 Antikörper
  • mKIAA1633 Antikörper

Bezeichner auf Proteinebene für CDK5RAP2

CDK5 regulatory subunit-associated protein 2 , EGF-like-domain, multiple 5 , CDK5 regulatory subunit associated protein 2 , CDK5 regulatory subunit-associated protein 2-like , CDK5 activator-binding protein C48 , centrosomal protein 215 kDa

GENE ID SPEZIES
508100 Bos taurus
612705 Canis lupus familiaris
771445 Gallus gallus
100156240 Sus scrofa
733952 Xenopus (Silurana) tropicalis
100071839 Equus caballus
100459050 Pongo abelii
55755 Homo sapiens
214444 Mus musculus
286919 Rattus norvegicus
464695 Pan troglodytes
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